Research output per year
Research output per year
- 40 results
Search results
-
2025
Site-Selective Approaches to Attain Fluorescent Human Insulin Conjugates: Balancing the Site of Labeling and the In Vivo Activity
Alkhawaja, B., AlDabet, G., Alkhawaja, N., Ghanim, B. Y., Al-Kjatib, K., Reeksting , S., Michael, A., Abuarqoub,, D., Mohammad, M., Watts, A. & Qinna, N. A., 4 Mar 2025, In: ACS OMEGA. 10, 8, p. 8140-8151Research output: Contribution to journal › Article › peer-review
Open Access -
2024
Dissecting the stability of Atezolizumab with renewable amino acid-based ionic liquids: Colloidal stability and anticancer activity under thermal stress
Alkhawaja, B., Al-Akayleh, F., Al-Rubaye, Z., AlDabet, G., Bustami, M., Smairat, M., Agha, A. S. A. A., Nasereddin, J., Qinna, N., Michael, A. & Watts, A., 30 Jun 2024, In: International Journal of Biological Macromolecules. 270, 132208.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (SciVal)147 Downloads (Pure) -
Facile rebridging conjugation approach to attain monoclonal antibodies-targeted nanoparticles with enhanced antigen binding and payload delivery
Alkhawaja, B., Abuarqoub,, D., Al-natour, M., Alshaer, W., Abdallah, Q., Esawi, E., Jaber, M., Alkhawaja, N., Ghanim, B. Y., Qinna, N. & Watts, A., 16 Oct 2024, In: Bioconjugate Chemistry. 35, 10, p. 1491-1502 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Staphylococcal complement evasion protein Sbi stabilises C3d dimers by inducing an N-terminal helix swap
Dunphy, R., Wahid, A., Back, C., Martin, B., Watts, A., Dodson, C., Crennell, S. & Van Den Elsen, J., 25 May 2022, In: Frontiers in Immunology. 13, 892234.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (SciVal)8 Downloads (Pure) -
2021
Insights into the structure-function relationships of dimeric C3d fragments
Wahid, A., Dunphy, R., Macpherson, A., Gibson, B., Kulik, L., Whale, K., Back, C., Hallam, T., Alkhawaja, B., Martin, B., Meschede, I., Laabei, M., Lawson, A., Holers, V. M., Watts, A., Crennell, S., Harris, C., Marchbank, K. & Van Den Elsen, J., 9 Aug 2021, In: Frontiers in Immunology. 12, 714055.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (SciVal)81 Downloads (Pure) -
2020
High PD-1/PD-L1 Checkpoint Interaction Infers Tumor Selection and Therapeutic Sensitivity to Anti-PD-1/PD-L1 Treatment
Sanchez-Magraner, L., Miles, J., Baker, C. L., Applebee, C., Lee, D.-J., Elsheikh, S., Lashin, S., Withers, K., Watts, A., Parry, R., Edmead, C., Lopez, J. I., Mehta, R., Italiano, A., Ward, S. G., Parker, P. J. & Larijani, B., 31 Oct 2020, In: Cancer Research. 80, 19, p. 4244-4257 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (SciVal)99 Downloads (Pure) -
2019
Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant
Yang, Y., Back, C., Gräwert, M., Wahid, A., Denton, H., Kildani, R., Paulin, J., Wörner, K., Kaiser, W., Svergun, D., Sartbaeva, A., Watts, A., Marchbank, K. J. & Van Den Elsen, J., 11 Jan 2019, In: Frontiers in Immunology. 9, p. 1-17 17 p., 3139.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (SciVal)146 Downloads (Pure) -
2018
Structural and functional analysis of anti-influenza activity of 4-, 7-, 8- and 9-deoxygenated 2,3-difluoro-N-acetylneuraminic acid derivatives
McKimm-Breschkin, J. L., Barrett, S., Pilling, P. A., Hader, S., Watts, A. & Streltsov, V., 8 Mar 2018, In: Journal of Medicinal Chemistry. 61, 5, p. 1921–1933 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (SciVal)120 Downloads (Pure) -
The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase
Chen, Z., Marce Villa, P., Resende, R., Alzari, P. M., Frasch, A. C., Van Den Elsen, J., Crennell, S. & Watts, A., 5 Oct 2018, In: European Journal of Medicinal Chemistry. 158, p. 25-33 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (SciVal)139 Downloads (Pure) -
2017
In Situ Quenching of Trialkylphosphine Reducing Agents Using Water-Soluble PEG-Azides Improves Maleimide Conjugation to Proteins
Kantner, T., Alkhawaja, B. & Watts, A., 30 Sept 2017, In: ACS OMEGA. 2, 9, p. 5785-5791 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (SciVal)292 Downloads (Pure) -
2016
Characterization of reactions between water soluble trialkylphosphines and thiol alkylating reagents: implications for protein-conjugation reactions
Watts, A. & Kantner, T., 19 Oct 2016, In: Bioconjugate Chemistry. 27, 10, p. 2400-2406Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (SciVal)736 Downloads (Pure) -
2015
Evaluation of the physiochemical and functional stability of diluted REMSIMA® upon extended storage—A study compliant with NHS (UK) guidance
Young, B. L., Ali Khan, M., Chapman, T. J., Parry, R., Connolly, M. A. & Watts, A. G., 30 Dec 2015, In: International Journal of Pharmaceutics. 496, 2, p. 421-431 11 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (SciVal) -
Tripartite ATP-independent Periplasmic (TRAP) Transporters use an arginine-mediated selectivity filter for high affinity substrate binding
Fischer, M., Hopkins, A. P., Severi, E., Hawkhead, J., Bawdon, D., Watts, A. G., Hubbard, R. E. & Thomas, G. H., Nov 2015, In: Journal of Biological Chemistry. 290, 45, p. 27113-27123 11 p.Research output: Contribution to journal › Article › peer-review
27 Citations (SciVal) -
2013
Analogs design, synthesis and biological evaluation of peptidomimetics with potential anti-HCV activity
Lasheen, D. S., Ismail, M. A. H., Abou El Ella, D. A., Ismail, N. S. M., Eid, S., Vleck, S., Glenn, J. S., Watts, A. G. & Abouzid, K. A. M., 15 May 2013, In: Bioorganic and Medicinal Chemistry. 21, 10, p. 2742-2755Research output: Contribution to journal › Article › peer-review
10 Citations (SciVal) -
Mechanism-based covalent neuraminidase inhibitors with broad spectrum influenza antiviral activity
Kim, J.-H., Resende, R., Wennekes, T., Chen, H.-M., Bance, N., Buchini, S., Watts, A. G., Pilling, P., Streltsov, V. A., Petric, M., Liggins, R., Barrett, S., Mckimm-Breschkin, J. L., Niikura, M. & Withers, S. G., 5 Apr 2013, In: Science. 340, 6128, p. 71-75 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile173 Citations (SciVal)600 Downloads (Pure) -
The synthesis of a series of deoxygenated 2,3-difluoro-N-acetylneuraminic acid derivatives as potential sialidase inhibitors
Hader, S. & Watts, A., 7 Jun 2013, In: Carbohydrate Research. 374, p. 23-28 6 p.Research output: Contribution to journal › Article › peer-review
13 Citations (SciVal) -
2011
The Aspergillus fumigatus Sialidase Is a 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid Hydrolase (KDNase): Structural and mechanistic insights
Telford, J. C., Yeung, J. H. F., Xu, G. G., Kiefel, M. J., Watts, A., Hader, S., Chan, J., Bennet, A. J., Moore, M. M. & Taylor, G. L., 25 Mar 2011, In: Journal of Biological Chemistry. 286, 12, p. 10783-10792 10 p.Research output: Contribution to journal › Article › peer-review
34 Citations (SciVal) -
2009
Palladium-catalysed allylic amination for the direct synthesis of epi-4-alkylamino-N-acetylneuraminic acid derivatives
Resende, R., Glover, C. & Watts, A. G., 15 Jul 2009, In: Tetrahedron Letters. 50, 28, p. 4009-4011 3 p.Research output: Contribution to journal › Article › peer-review
7 Citations (SciVal) -
2008
A key role for redox signaling in rapid P2X7 receptor-induced IL-1 β processing in human monocytes
Hewinson, J., Moore, S. F., Glover, C., Watts, A. & Mackenzie, A. B., 15 Jun 2008, In: The Journal of Immunology. 180, 12, p. 8410-8420 11 p.Research output: Contribution to journal › Article › peer-review
101 Citations (SciVal) -
Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis
Damager, I., Buchini, S., Amaya, M. F., Buschiazzo, A., Alzari, P., Frasch, A. C., Watts, A. G. & Withers, S. G., 18 Mar 2008, In: Biochemistry. 47, 11, p. 3507-3512 6 p.Research output: Contribution to journal › Article › peer-review
56 Citations (SciVal) -
The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates
Newstead, S. L., Potter, J. A., Wilson, J. C., Xu, G., Chien, C.-H., Watts, A. G., Withers, S. G. & Taylor, G. L., 4 Apr 2008, In: Journal of Biological Chemistry. 283, 14, p. 9080-9088 9 p.Research output: Contribution to journal › Article › peer-review
111 Citations (SciVal) -
2006
Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid-binding virulence factor from Haemophilus Influenzae
Müller, A., Severi, E., Mulligan, C., Watts, A. G., Kelly, D. J., Wilson, K. S., Wilkinson, A. J. & Thomas, G. H., 2006, In: Journal of Biological Chemistry. 281, 31, p. 22212-22222 11 p.Research output: Contribution to journal › Article › peer-review
76 Citations (SciVal) -
Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on trypanosoma rangeli sialidase
Watts, A. G., Oppezzo, P., Withers, S. G., Alzari, P. M. & Buschiazzo, A., 2006, In: Journal of Biological Chemistry. 281, 7, p. 4149-4155 7 p.Research output: Contribution to journal › Article › peer-review
80 Citations (SciVal) -
Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis
Lairson, L. L., Watts, A. G., Wakarchuk, W. W. & Withers, S. G., 2006, In: Nature Chemical Biology. 2, 12, p. 724-728 5 p.Research output: Contribution to journal › Article › peer-review
65 Citations (SciVal) -
2004
An investigation into the synthesis of some molecules related to methyl acarviosin
McDonough, M. J., Stick, R. V., Tilbrook, D. M. G. & Watts, A. G., 2004, In: Australian Journal of Chemistry. 57, 3, p. 233-241 9 p.Research output: Contribution to journal › Article › peer-review
6 Citations (SciVal) -
Glycosynthase-catalysed formation of modified polysaccharide microstructures
Watts, A. G. & Withers, S. G., 2004, In: Biochemical Journal. 380, p. e1-e2Research output: Contribution to journal › Article › peer-review
9 Citations (SciVal) -
Modifying the regioselectivity of glycosynthase reactions through changes in the acceptor
Stick, R. V., Stubbs, K. A. & Watts, A. G., 2004, In: Australian Journal of Chemistry. 57, p. 779-786 8 p.Research output: Contribution to journal › Article › peer-review
17 Citations (SciVal) -
Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog
Chiu, C. P. C., Watts, A. G., Lairson, L. L., Gilbert, M., Lim, D., Wakarchuk, W. W., Withers, S. G. & Strynadka, N. C. J., 2004, In: Nature Structural and Molecular Biology. 11, 2, p. 163-170 8 p.Research output: Contribution to journal › Article › peer-review
188 Citations (SciVal) -
Structural insights into the catalytic mechanism of trypanosoma cruzi trans-sialidase
Amaya, M. F., Watts, A. G., Damager, I., Wehenkel, A., Nguyen, T., Buschiazzo, A., Paris, G., Frasch, A. C., Withers, S. G. & Alzari, P. M., 2004, In: Structure. 12, 5, p. 775-784 10 p.Research output: Contribution to journal › Article › peer-review
198 Citations (SciVal) -
The fluorination (at C5) of some derivatives of D-glucose
Skelton, B. W., Stick, R. V., Stubbs, K. A., Watts, A. G. & White, A. H., 2004, In: Australian Journal of Chemistry. 57, p. 345-353 9 p.Research output: Contribution to journal › Article › peer-review
13 Citations (SciVal) -
The synthesis of some mechanistic probes for sialic acid processing enzymes and the labeling of a sialidase from Trypanosoma rangeli
Watts, A. G. & Withers, S. G., 2004, In: Canadian Journal of Chemistry. 82, p. 1581-1588 8 p.Research output: Contribution to journal › Article › peer-review
45 Citations (SciVal) -
2003
Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile
Watts, A. G., Damager, I., Amaya, M. L., Buschiazzo, A., Alzari, P. M., Frasch, A. C. & Withers, S. G., 2003, In: Journal of the American Chemical Society. 125, 25, p. 7532-7533 2 p.Research output: Contribution to journal › Article › peer-review
197 Citations (SciVal) -
2002
A direct synthesis of 2-deoxy-2-fluoro-α-D-[6- 3 H]glucopyranosyl uridine-5'-diphosphate
Stick, R. V. & Watts, A. G., 2002, In: Australian Journal of Chemistry. 55, p. 327-329 3 p.Research output: Contribution to journal › Article › peer-review
-
A direct synthesis of 2-deoxy-2-fluoro-α-D-[6-3H]glucopyranosyl uridine-5′-diphosphate
Stick, R. V. & Watts, A. G., 2 Aug 2002, In: Australian Journal of Chemistry. 55, 5, p. 327-329 3 p.Research output: Contribution to journal › Article › peer-review
1 Citation (SciVal) -
A new catalyst for the reductive elimination of acylated glycosyl bromides to form glycals
Stick, R. V., Stubbs, K. A., Tilbrook, D. M. G. & Watts, A. G., 2002, In: Australian Journal of Chemistry. 55, p. 83-85 3 p.Research output: Contribution to journal › Article › peer-review
9 Citations (SciVal) -
The chameleon of retaining glycoside hydrolases and retaining glycosol transferases: the catalytic nucleophile
Stick, R. V. & Watts, A. G., 2002, In: Chemical Monthly. 133, p. 541-554 14 p.Research output: Contribution to journal › Article › peer-review
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The Chameleon of Retaining Glycoside Hydrolases and Retaining Glycosyl Transferases: The Catalytic Nucleophile
Stick, R. V. & Watts, A. G., 1 Apr 2002, In: Monatshefte fur Chemie. 133, 4 SPI, p. 541-554 15 p.Research output: Contribution to journal › Article › peer-review
2 Citations (SciVal) -
The chameleon of retaining glycoside hydrolases and retaining glycosyl transferases: The catalytic nucleophile
Stick, R. V. & Watts, A. G., 27 Apr 2002, In: Monatshefte fur Chemie. 133, 4, p. 541-554 14 p.Research output: Contribution to journal › Article › peer-review
13 Citations (SciVal) -
1998
The synthesis of a diastereoisomer of methyl acarviosin
McAuliffe, J. C., Stick, R. V., Tilbrook, D. M. G. & Watts, A. G., 1 Jan 1998, In: Australian Journal of Chemistry. 51, 2, p. 91-96 6 p.Research output: Contribution to journal › Article › peer-review
9 Citations (SciVal) -
1994
A combined x-ray and neutron diffraction study of selectively deuterated melittin in phospholipid bilayers: Effect of pH
Bradshaw, J. P., Dempsey, C. E. & Watts, A., 1994, In: Molecular Membrane Biology. 11, 2, p. 79-86 8 p.Research output: Contribution to journal › Article › peer-review