Andrew Watts

2025

Electrochemical sensors for the detection of immune checkpoint related proteins and their role in cancer companion diagnostics

Barnaby, L., Watts, A. & Estrela, P., 31 Mar 2025, In: Biosensors and Bioelectronics: X. 22, 16 p., 100561.

Research output: Contribution to journal › Review article › peer-review

Open Access

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22 Downloads (Pure)

Site-Selective Approaches to Attain Fluorescent Human Insulin Conjugates: Balancing the Site of Labeling and the In Vivo Activity

Alkhawaja, B., AlDabet, G., Alkhawaja, N., Ghanim, B. Y., Al-Kjatib, K., Reeksting , S., Michael, A., Abuarqoub,, D., Mohammad, M., Watts, A. & Qinna, N. A., 4 Mar 2025, In: ACS OMEGA. 10, 8, p. 8140-8151

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Dissecting the stability of Atezolizumab with renewable amino acid-based ionic liquids: Colloidal stability and anticancer activity under thermal stress

Alkhawaja, B., Al-Akayleh, F., Al-Rubaye, Z., AlDabet, G., Bustami, M., Smairat, M., Agha, A. S. A. A., Nasereddin, J., Qinna, N., Michael, A. & Watts, A., 30 Jun 2024, In: International Journal of Biological Macromolecules. 270, 132208.

Research output: Contribution to journal › Article › peer-review

Open Access

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6 Citations (SciVal)

147 Downloads (Pure)

Facile rebridging conjugation approach to attain monoclonal antibodies-targeted nanoparticles with enhanced antigen binding and payload delivery

Alkhawaja, B., Abuarqoub,, D., Al-natour, M., Alshaer, W., Abdallah, Q., Esawi, E., Jaber, M., Alkhawaja, N., Ghanim, B. Y., Qinna, N. & Watts, A., 16 Oct 2024, In: Bioconjugate Chemistry. 35, 10, p. 1491-1502 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Staphylococcal complement evasion protein Sbi stabilises C3d dimers by inducing an N-terminal helix swap

Dunphy, R., Wahid, A., Back, C., Martin, B., Watts, A., Dodson, C., Crennell, S. & Van Den Elsen, J., 25 May 2022, In: Frontiers in Immunology. 13, 892234.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (SciVal)

8 Downloads (Pure)

2021

Insights into the structure-function relationships of dimeric C3d fragments

Wahid, A., Dunphy, R., Macpherson, A., Gibson, B., Kulik, L., Whale, K., Back, C., Hallam, T., Alkhawaja, B., Martin, B., Meschede, I., Laabei, M., Lawson, A., Holers, V. M., Watts, A., Crennell, S., Harris, C., Marchbank, K. & Van Den Elsen, J., 9 Aug 2021, In: Frontiers in Immunology. 12, 714055.

Research output: Contribution to journal › Article › peer-review

Open Access

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5 Citations (SciVal)

81 Downloads (Pure)

2020

BIS(2-HALOACETAMIDO)-COMPOUNDS FOR USE AS LINKING AGENTS AND RESULTANT PRODUCTS WHICH COMPRISE ANTIBODIES, HALF-ANTIBODIES AND ANTIBODY FRAGMENTS

Watts, A. (Inventor) & Alkhawaja, B. (Inventor), 30 Dec 2020, IPC No. C07K16/00, A61K47/00, C07C233/00, C07C247/04, Patent No. WO2020260514, Priority date 25 Jun 2019, Priority No. GB201909103A

Research output: Patent

High PD-1/PD-L1 Checkpoint Interaction Infers Tumor Selection and Therapeutic Sensitivity to Anti-PD-1/PD-L1 Treatment

Sanchez-Magraner, L., Miles, J., Baker, C. L., Applebee, C., Lee, D.-J., Elsheikh, S., Lashin, S., Withers, K., Watts, A., Parry, R., Edmead, C., Lopez, J. I., Mehta, R., Italiano, A., Ward, S. G., Parker, P. J. & Larijani, B., 31 Oct 2020, In: Cancer Research. 80, 19, p. 4244-4257 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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32 Citations (SciVal)

99 Downloads (Pure)

2019

Structural Stabilisation of Disulphide-Linked Fluid-Phase C3d Dimers by Sbi Suggests a Novel B cell Subversion Strategy by Staphylococcus aureus

Wahid, A., Dunphy, R., Gibson, B., Back, C., Hallam, T., Alkhawaja, B., Harris, C., Crennell, S., Watts, A., Marchbank, K. & Van Den Elsen, J., Oct 2019, p. 437.

Research output: Contribution to conference › Paper

Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

Yang, Y., Back, C., Gräwert, M., Wahid, A., Denton, H., Kildani, R., Paulin, J., Wörner, K., Kaiser, W., Svergun, D., Sartbaeva, A., Watts, A., Marchbank, K. J. & Van Den Elsen, J., 11 Jan 2019, In: Frontiers in Immunology. 9, p. 1-17 17 p., 3139.

Research output: Contribution to journal › Article › peer-review

Open Access

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11 Citations (SciVal)

146 Downloads (Pure)

2018

Immunogenic compositions comprising Sbi protein and uses thereof

Van Den Elsen, J. (Inventor), Watts, A. (Inventor) & Marchbank, K. J. (Inventor), 31 May 2018, IPC No. A61K39/04, A61K39/09, A61K39/385, A61K39/39, Patent No. WO2018096089A1, 24 Nov 2017, Priority date 25 Nov 2016, Priority No. GB201619965A

Research output: Patent

Structural and functional analysis of anti-influenza activity of 4-, 7-, 8- and 9-deoxygenated 2,3-difluoro-N-acetylneuraminic acid derivatives

McKimm-Breschkin, J. L., Barrett, S., Pilling, P. A., Hader, S., Watts, A. & Streltsov, V., 8 Mar 2018, In: Journal of Medicinal Chemistry. 61, 5, p. 1921–1933 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (SciVal)

120 Downloads (Pure)

The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase

Chen, Z., Marce Villa, P., Resende, R., Alzari, P. M., Frasch, A. C., Van Den Elsen, J., Crennell, S. & Watts, A., 5 Oct 2018, In: European Journal of Medicinal Chemistry. 158, p. 25-33 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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12 Citations (SciVal)

139 Downloads (Pure)

2017

In Situ Quenching of Trialkylphosphine Reducing Agents Using Water-Soluble PEG-Azides Improves Maleimide Conjugation to Proteins

Kantner, T., Alkhawaja, B. & Watts, A., 30 Sept 2017, In: ACS OMEGA. 2, 9, p. 5785-5791 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Citations (SciVal)

292 Downloads (Pure)

2016

Characterization of reactions between water soluble trialkylphosphines and thiol alkylating reagents: implications for protein-conjugation reactions

Watts, A. & Kantner, T., 19 Oct 2016, In: Bioconjugate Chemistry. 27, 10, p. 2400-2406

Research output: Contribution to journal › Article › peer-review

Open Access

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33 Citations (SciVal)

736 Downloads (Pure)

2015

Evaluation of the physiochemical and functional stability of diluted REMSIMA® upon extended storage—A study compliant with NHS (UK) guidance

Young, B. L., Ali Khan, M., Chapman, T. J., Parry, R., Connolly, M. A. & Watts, A. G., 30 Dec 2015, In: International Journal of Pharmaceutics. 496, 2, p. 421-431 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (SciVal)

Tripartite ATP-independent Periplasmic (TRAP) Transporters use an arginine-mediated selectivity filter for high affinity substrate binding

Fischer, M., Hopkins, A. P., Severi, E., Hawkhead, J., Bawdon, D., Watts, A. G., Hubbard, R. E. & Thomas, G. H., Nov 2015, In: Journal of Biological Chemistry. 290, 45, p. 27113-27123 11 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (SciVal)

2013

Analogs design, synthesis and biological evaluation of peptidomimetics with potential anti-HCV activity

Lasheen, D. S., Ismail, M. A. H., Abou El Ella, D. A., Ismail, N. S. M., Eid, S., Vleck, S., Glenn, J. S., Watts, A. G. & Abouzid, K. A. M., 15 May 2013, In: Bioorganic and Medicinal Chemistry. 21, 10, p. 2742-2755

Research output: Contribution to journal › Article › peer-review

10 Citations (SciVal)

Mechanism-based covalent neuraminidase inhibitors with broad spectrum influenza antiviral activity

Kim, J.-H., Resende, R., Wennekes, T., Chen, H.-M., Bance, N., Buchini, S., Watts, A. G., Pilling, P., Streltsov, V. A., Petric, M., Liggins, R., Barrett, S., Mckimm-Breschkin, J. L., Niikura, M. & Withers, S. G., 5 Apr 2013, In: Science. 340, 6128, p. 71-75 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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173 Citations (SciVal)

600 Downloads (Pure)

The synthesis of a series of deoxygenated 2,3-difluoro-N-acetylneuraminic acid derivatives as potential sialidase inhibitors

Hader, S. & Watts, A., 7 Jun 2013, In: Carbohydrate Research. 374, p. 23-28 6 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

2012

Functionalising reagents and their uses

Watts, A. (Inventor), Kantner, T. (Inventor) & Mackenzie, A. (Inventor), 11 Jan 2012, Patent No. CN102317305 (A)

Research output: Patent

Materials and methods relating to glycosylation

Watts, A. (Inventor), Kantner, T. (Inventor) & Mackenzie, A. (Inventor), 25 Apr 2012, IPC No. A61K47/48, Patent No. EP2442831 (A2)

Research output: Patent

2011

The Aspergillus fumigatus Sialidase Is a 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid Hydrolase (KDNase): Structural and mechanistic insights

Telford, J. C., Yeung, J. H. F., Xu, G. G., Kiefel, M. J., Watts, A., Hader, S., Chan, J., Bennet, A. J., Moore, M. M. & Taylor, G. L., 25 Mar 2011, In: Journal of Biological Chemistry. 286, 12, p. 10783-10792 10 p.

Research output: Contribution to journal › Article › peer-review

34 Citations (SciVal)

Thiol-Functionalising Reagents and Their Uses

Watts, A. (Inventor), Kantner, T. (Inventor) & Mackenzie, A. (Inventor), 12 Oct 2011, IPC No. C07K1/13, Patent No. EP2373675 (A2)

Research output: Patent

2010

Compounds for Treating Viral Infections

Watts, A. (Inventor), 18 Mar 2010, IPC No. A61K31/7012, A61P31/12, C07H7/02, Patent No. WO2010029302 (A2), Priority date 11 Sept 2008, Priority No. GB0816679A

Research output: Patent

Materials and Methods Relating to Glycosylation

Watts, A. (Inventor), Mackenzie, A. (Inventor) & Kantner, T. (Inventor), 23 Dec 2010, IPC No. A61K47/48, Patent No. CA2768155 (A1)

Research output: Patent

MATERIALS AND METHODS RELATING TO GLYCOSYLATION

Watts, Andrew, G. (Inventor), MacKenzie, Amanda, B. (Inventor) & Kantner, T. (Inventor), 23 Dec 2010, IPC No. A61K47/48, Patent No. WO2010146362, Priority date 16 Jun 2009, Priority No. US18743409P

Research output: Patent

2009

Detection and Functionalisation of S-Nitrosylated Polypeptides

Mackenzie, A. (Inventor) & Watts, A. (Inventor), 26 Feb 2009, IPC No. G01N33/68, Patent No. WO2009024791 (A1), 21 Aug 2008, Priority date 21 Aug 2007, Priority No. 0716328.0

Research output: Patent

Palladium-catalysed allylic amination for the direct synthesis of epi-4-alkylamino-N-acetylneuraminic acid derivatives

Resende, R., Glover, C. & Watts, A. G., 15 Jul 2009, In: Tetrahedron Letters. 50, 28, p. 4009-4011 3 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (SciVal)

2008

A key role for redox signaling in rapid P2X₇ receptor-induced IL-1 β processing in human monocytes

Hewinson, J., Moore, S. F., Glover, C., Watts, A. & Mackenzie, A. B., 15 Jun 2008, In: The Journal of Immunology. 180, 12, p. 8410-8420 11 p.

Research output: Contribution to journal › Article › peer-review

101 Citations (SciVal)

Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis

Damager, I., Buchini, S., Amaya, M. F., Buschiazzo, A., Alzari, P., Frasch, A. C., Watts, A. G. & Withers, S. G., 18 Mar 2008, In: Biochemistry. 47, 11, p. 3507-3512 6 p.

Research output: Contribution to journal › Article › peer-review

56 Citations (SciVal)

The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates

Newstead, S. L., Potter, J. A., Wilson, J. C., Xu, G., Chien, C.-H., Watts, A. G., Withers, S. G. & Taylor, G. L., 4 Apr 2008, In: Journal of Biological Chemistry. 283, 14, p. 9080-9088 9 p.

Research output: Contribution to journal › Article › peer-review

111 Citations (SciVal)

2006

Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid-binding virulence factor from Haemophilus Influenzae

Müller, A., Severi, E., Mulligan, C., Watts, A. G., Kelly, D. J., Wilson, K. S., Wilkinson, A. J. & Thomas, G. H., 2006, In: Journal of Biological Chemistry. 281, 31, p. 22212-22222 11 p.

Research output: Contribution to journal › Article › peer-review

76 Citations (SciVal)

Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on trypanosoma rangeli sialidase

Watts, A. G., Oppezzo, P., Withers, S. G., Alzari, P. M. & Buschiazzo, A., 2006, In: Journal of Biological Chemistry. 281, 7, p. 4149-4155 7 p.

Research output: Contribution to journal › Article › peer-review

80 Citations (SciVal)

Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis

Lairson, L. L., Watts, A. G., Wakarchuk, W. W. & Withers, S. G., 2006, In: Nature Chemical Biology. 2, 12, p. 724-728 5 p.

Research output: Contribution to journal › Article › peer-review

65 Citations (SciVal)

2004

An investigation into the synthesis of some molecules related to methyl acarviosin

McDonough, M. J., Stick, R. V., Tilbrook, D. M. G. & Watts, A. G., 2004, In: Australian Journal of Chemistry. 57, 3, p. 233-241 9 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (SciVal)

Glycosynthase-catalysed formation of modified polysaccharide microstructures

Watts, A. G. & Withers, S. G., 2004, In: Biochemical Journal. 380, p. e1-e2

Research output: Contribution to journal › Article › peer-review

9 Citations (SciVal)

Modifying the regioselectivity of glycosynthase reactions through changes in the acceptor

Stick, R. V., Stubbs, K. A. & Watts, A. G., 2004, In: Australian Journal of Chemistry. 57, p. 779-786 8 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (SciVal)

Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog

Chiu, C. P. C., Watts, A. G., Lairson, L. L., Gilbert, M., Lim, D., Wakarchuk, W. W., Withers, S. G. & Strynadka, N. C. J., 2004, In: Nature Structural and Molecular Biology. 11, 2, p. 163-170 8 p.

Research output: Contribution to journal › Article › peer-review

188 Citations (SciVal)

Structural insights into the catalytic mechanism of trypanosoma cruzi trans-sialidase

Amaya, M. F., Watts, A. G., Damager, I., Wehenkel, A., Nguyen, T., Buschiazzo, A., Paris, G., Frasch, A. C., Withers, S. G. & Alzari, P. M., 2004, In: Structure. 12, 5, p. 775-784 10 p.

Research output: Contribution to journal › Article › peer-review

198 Citations (SciVal)

The fluorination (at C5) of some derivatives of D-glucose

Skelton, B. W., Stick, R. V., Stubbs, K. A., Watts, A. G. & White, A. H., 2004, In: Australian Journal of Chemistry. 57, p. 345-353 9 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

The synthesis of some mechanistic probes for sialic acid processing enzymes and the labeling of a sialidase from Trypanosoma rangeli

Watts, A. G. & Withers, S. G., 2004, In: Canadian Journal of Chemistry. 82, p. 1581-1588 8 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (SciVal)

2003

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile

Watts, A. G., Damager, I., Amaya, M. L., Buschiazzo, A., Alzari, P. M., Frasch, A. C. & Withers, S. G., 2003, In: Journal of the American Chemical Society. 125, 25, p. 7532-7533 2 p.

Research output: Contribution to journal › Article › peer-review

197 Citations (SciVal)

2002

A direct synthesis of 2-deoxy-2-fluoro-α-D-[6- 3 H]glucopyranosyl uridine-5'-diphosphate

Stick, R. V. & Watts, A. G., 2002, In: Australian Journal of Chemistry. 55, p. 327-329 3 p.

Research output: Contribution to journal › Article › peer-review

A direct synthesis of 2-deoxy-2-fluoro-α-D-[6-³H]glucopyranosyl uridine-5′-diphosphate

Stick, R. V. & Watts, A. G., 2 Aug 2002, In: Australian Journal of Chemistry. 55, 5, p. 327-329 3 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (SciVal)

A new catalyst for the reductive elimination of acylated glycosyl bromides to form glycals

Stick, R. V., Stubbs, K. A., Tilbrook, D. M. G. & Watts, A. G., 2002, In: Australian Journal of Chemistry. 55, p. 83-85 3 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (SciVal)

The chameleon of retaining glycoside hydrolases and retaining glycosol transferases: the catalytic nucleophile

Stick, R. V. & Watts, A. G., 2002, In: Chemical Monthly. 133, p. 541-554 14 p.

Research output: Contribution to journal › Article › peer-review

The Chameleon of Retaining Glycoside Hydrolases and Retaining Glycosyl Transferases: The Catalytic Nucleophile

Stick, R. V. & Watts, A. G., 1 Apr 2002, In: Monatshefte fur Chemie. 133, 4 SPI, p. 541-554 15 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (SciVal)

The chameleon of retaining glycoside hydrolases and retaining glycosyl transferases: The catalytic nucleophile

Stick, R. V. & Watts, A. G., 27 Apr 2002, In: Monatshefte fur Chemie. 133, 4, p. 541-554 14 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

1998

The synthesis of a diastereoisomer of methyl acarviosin

McAuliffe, J. C., Stick, R. V., Tilbrook, D. M. G. & Watts, A. G., 1 Jan 1998, In: Australian Journal of Chemistry. 51, 2, p. 91-96 6 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (SciVal)

Andrew Watts

Research output

Search results