Projects per year
Personal profile
Research interests
My research sits at the intersection of chemistry and biology, focusing on the creation of novel chemistries to help understand biological processes and exploit the potential of biological molecules for societal benefit, in particular the development of novel biological therapeutics.
Research projects in our group include:
- Small molecule covalent inhibitors of enzymes involved in disease.
- Mono-alkylating bioconjugation chemistries for development of antibody-drug conjugates.
- Methodologies to expand bioconjugate modalities.
- Controlling effector function of monoclonal antibodies through chemical modification.
- Disulphide re-bridging strategies for creation of bi-specific and tri-specific antibody conjugates
- Targeted delivery of RNA-based therapeutics
Other responsibilities
Director of Knowledge Exchange, Faculty of Science.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Organic Chemistry, Doctor of Philosophy, The University of Western Australia
Award Date: 1 Apr 2001
Organic Chemistry, Bachelor of Science, The University of Western Australia
Award Date: 1 Nov 1996
External positions
Post-Doctoral Research Fellow, University of British Columbia
2002 → 2004
Keywords
- Chemical Biology
- Bioconjugation
- Therapeutic Antibodies
- Protein Conjugates
- Chemical Immunology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Increasing capacity in the NHS - Development of technologies to increase delivery of injectible medicines in the community
Watts, A. (PI), Fincham Haines, T. (CoI), Fotaki, N. (CoI), Martinez Hernandez, U. (CoI), Tosh, D. (CoI) & Şimşek, Ö. (CoI)
Engineering and Physical Sciences Research Council
1/01/24 → 31/12/28
Project: Research council
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Hospice prescribing practices and influences
Jones, M. (PI), Mason, F. (Researcher), Watts, A. (CoI) & Connolly, M. (CoI)
4/01/21 → 31/05/24
Project: UK industry
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KTP with Qualasept Limited (2)
Watts, A. (PI) & Tosh, D. (CoI)
11/02/19 → 10/02/22
Project: Central government, health and local authorities
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IAA - Exploitation of Novel Protein Conjugation Chemistry
Van Den Elsen, J. (PI) & Watts, A. (CoI)
Engineering and Physical Sciences Research Council
1/06/18 → 31/03/20
Project: Research council
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Investigations into the physico-chemical stability of multi-drug combinations in palliate care
Watts, A. (PI)
16/10/17 → 31/01/23
Project: UK industry
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A facile rebridging conjugation approach to attain monoclonal antibodies-targeted nanoparticles with enhanced antigen binding and payload delivery
Watts, A., Abdallah, Q., Abuarqoub, D., Jaber, M., Alkhawaja, N., Qinna, N., Alkhawaja, B., Al-natour, M., Ghanim, B., Esawi, E. & Alshaer, W., 20 Aug 2024, (Acceptance date) In: Bioconjugate Chemistry.Research output: Contribution to journal › Article › peer-review
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Dissecting the stability of Atezolizumab with renewable amino acid-based ionic liquids: Colloidal stability and anticancer activity under thermal stress
Alkhawaja, B., Al-Akayleh, F., Al-Rubaye, Z., AlDabet, G., Bustami, M., Smairat, M., Agha, A. S. A. A., Nasereddin, J., Qinna, N., Michael, A. & Watts, A., 30 Jun 2024, In: International Journal of Biological Macromolecules. 270, 132208.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (SciVal)91 Downloads (Pure) -
Staphylococcal complement evasion protein Sbi stabilises C3d dimers by inducing an N-terminal helix swap
Dunphy, R., Wahid, A., Back, C., Martin, B., Watts, A., Dodson, C., Crennell, S. & Van Den Elsen, J., 25 May 2022, In: Frontiers in Immunology. 13, 892234.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (SciVal)8 Downloads (Pure) -
Insights into the structure-function relationships of dimeric C3d fragments
Wahid, A., Dunphy, R., Macpherson, A., Gibson, B., Kulik, L., Whale, K., Back, C., Hallam, T., Alkhawaja, B., Martin, B., Meschede, I., Laabei, M., Lawson, A., Holers, V. M., Watts, A., Crennell, S., Harris, C., Marchbank, K. & Van Den Elsen, J., 9 Aug 2021, In: Frontiers in Immunology. 12, 714055.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (SciVal)55 Downloads (Pure) -
BIS(2-HALOACETAMIDO)-COMPOUNDS FOR USE AS LINKING AGENTS AND RESULTANT PRODUCTS WHICH COMPRISE ANTIBODIES, HALF-ANTIBODIES AND ANTIBODY FRAGMENTS
Watts, A. (Inventor) & Alkhawaja, B. (Inventor), 30 Dec 2020, IPC No. C07K16/00, A61K47/00, C07C233/00, C07C247/04, Patent No. WO2020260514, Priority date 25 Jun 2019, Priority No. GB201909103AResearch output: Patent