1988 …2022

Research output per year

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Personal profile

Research interests

My main interests are to understand:

(i) how fetal growth is regulated such that a body of correct size and proportions is attained

(ii) how altered fetal growth can influence health in later life, including predisposition to cancer, obesity and diabetes.

These are big questions, relevant to important medical problems. Our approach has been to focus on a small group of genes regulated by genomic imprinting. Imprinted genes behave unusually in that they are expressed predominantly, if not exclusively, from only one of their two parental copies. Although only about 100 imprinted genes are known, a large proportion of them regulate fetal growth and/or adult physiology, with others influencing brain function and behaviour.

The Grb10 gene is expressed from the maternally-inherited copy in most fetal tissues outside of the central nervous system and we have shown that it acts to inhibit growth of both the embryo and placenta. In adult life the maternally-inherited Grb10 allele regulates insulin receptor signalling and body fat deposition and can, therefore, directly influence energy homeostasis. Recently, we found that in the brain Grb10 is expressed mainly from the paternal allele and we have discovered that this brain expression is linked with the control of social dominance behaviour. By gaining a deeper understanding of the different functions of Grb10 we aim to understand why this and other imprinted genes have evolved.

Current lab members

  • Xiao Hu
  • Kim Moorwood
  • Sasi Saminathan 

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Projects

MRC adipose regulation

Ward, A. & Moorwood, K.

MRC

3/01/192/01/22

Project: Research council

  • Research Output

    Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance

    Rienecker, K. D. A., Chavasse, A. T., Moorwood, K., Ward, A. & Isles, A. R., 1 Jan 2020, In : Genes, Brain and Behavior. 19, 1, e12571.

    Research output: Contribution to journalArticle

    Open Access
    File
    1 Citation (Scopus)

    Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior

    Dent, C. L., Humby, T., Lewis, K., Ward, A., Fischer-Colbrie, R., Wilkinson, L. S., Wilkins, J. F. & Isles, A. R., 1 May 2018, In : Genetics. 209, 1, p. 233-239 7 p.

    Research output: Contribution to journalArticle

    Open Access
    7 Citations (Scopus)

    Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

    Goodson, W. H., Lowe, L., Carpenter, D. O., Gilbertson, M., Manaf Ali, A., Lopez de Cerain Salsamendi, A., Lasfar, A., Carnero, A., Azqueta, A., Amedei, A., Charles, A. K., Collins, A. R., Ward, A., Salzberg, A. C., Colacci, A., Olsen, A-K., Berg, A., Barclay, B. J., Zhou, B. P., Blanco-Aparicio, C. & 153 others, Baglole, C. J., Dong, C., Mondello, C., Hsu, C-W., Naus, C. C., Yedjou, C., Curran, C. S., Laird, D. W., Koch, D. C., Carlin, D. J., Felsher, D. W., Roy, D., Brown, D. G., Ratovitski, E., Ryan, E. P., Corsini, E., Rojas, E., Moon, E-Y., Laconi, E., Marongiu, F., Al-Mulla, F., Chiaradonna, F., Darroudi, F., Martin, F. L., Van Schooten, F. J., Goldberg, G. S., Wagemaker, G., Nangami, G. N., Calaf, G. M., Williams, G., Wolf, G. T., Koppen, G., Brunborg, G., Lyerly, H. K., Krishnan, H., Ab Hamid, H., Yasaei, H., Sone, H., Kondoh, H., Salem, H. K., Hsu, H-Y., Park, H. H., Koturbash, I., Miousse, I. R., Scovassi, A. I., Klaunig, J. E., Vondráček, J., Raju, J., Roman, J., Wise, J. P., Whitfield, J. R., Woodrick, J., Christopher, J. A., Ochieng, J., Martinez-Leal, J. F., Weisz, J., Kravchenko, J., Sun, J., Prudhomme, K. R., Narayanan, K. B., Cohen-Solal, K. A., Moorwood, K., Gonzalez, L., Soucek, L., Jian, L., D'Abronzo, L. S., Lin, L-T., Li, L., Gulliver, L., McCawley, L. J., Memeo, L., Vermeulen, L., Leyns, L., Zhang, L., Valverde, M., Khatami, M., Romano, M. F., Chapellier, M., Williams, M. A., Wade, M., Manjili, M. H., Lleonart, M. E., Xia, M., Gonzalez, M. J., Karamouzis, M. V., Kirsch-Volders, M., Vaccari, M., Kuemmerle, N. B., Singh, N., Cruickshanks, N., Kleinstreuer, N., van Larebeke, N., Ahmed, N., Ogunkua, O., Krishnakumar, P. K., Vadgama, P., Marignani, P. A., Ghosh, P. M., Ostrosky-Wegman, P., Thompson, P. A., Dent, P., Heneberg, P., Darbre, P., Sing Leung, P., Nangia-Makker, P., Cheng, Q. S., Robey, R. B., Al-Temaimi, R., Roy, R., Andrade-Vieira, R., Sinha, R. K., Mehta, R., Vento, R., Di Fiore, R., Ponce-Cusi, R., Dornetshuber-Fleiss, R., Nahta, R., Castellino, R. C., Palorini, R., Abd Hamid, R., Langie, S. A. S., Eltom, S. E., Brooks, S. A., Ryeom, S., Wise, S. S., Bay, S. N., Harris, S. A., Papagerakis, S., Romano, S., Pavanello, S., Eriksson, S., Forte, S., Casey, S. C., Luanpitpong, S., Lee, T-J., Otsuki, T., Chen, T., Massfelder, T., Sanderson, T., Guarnieri, T., Hultman, T., Dormoy, V., Odero-Marah, V., Sabbisetti, V., Maguer-Satta, V., Rathmell, W. K., Engström, W., Decker, W. K., Bisson, W. H., Rojanasakul, Y., Luqmani, Y., Chen, Z. & Hu, Z., Jun 2015, In : Carcinogenesis. 36 Suppl 1, p. S254-S296

    Research output: Contribution to journalArticle

    Open Access
  • 119 Citations (Scopus)

    Coadaptation between mother and offspring: Why not?

    Wolf, J. B., Cowley, M. & Ward, A., 31 Mar 2015, In : PLoS Biology. 13, 3, e1002085.

    Research output: Contribution to journalArticle

    Open Access
    1 Citation (Scopus)

    Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

    Ferrón, S. R., Radford, E. J., Domingo-Muelas, A., Kleine, I., Ramme, A., Gray, D., Sandovici, I., Constancia, M., Ward, A., Menheniott, T. R. & Ferguson-Smith, A. C., 15 Sep 2015, In : Nature Communications. 6, p. 1-12 12 p., 8265.

    Research output: Contribution to journalArticle

    Open Access
  • 32 Citations (Scopus)

    Thesis

    An investigation of mouse Basp1 and Wt1-AS, genes involved in the regulation of the Wilms' Tumour suppressor protein, Wt1

    Author: Allsop, J., 1 Jan 2008

    Supervisor: Ward, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Biochemical evidence that the Dlk1 and Grb10 signalling proteins interact through a common growth regulatory pathway

    Author: Hu, X., 21 Feb 2018

    Supervisor: Ward, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Brain transcriptome analyses of paternal-specific mutant GRB10KO and potential insights into dominance behaviour

    Author: Al Zadjali, A., 23 Aug 2018

    Supervisor: Urrutia, A. (Supervisor) & Ward, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Characterisation in mice of a conserved sequence, Mcr2, associated with the Wilms' tumour 1 (Wt1) locus

    Author: Meza Menchaca, T., 1 Sep 2010

    Supervisor: Ward, A. (Supervisor) & Moorwood, K. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Characterisation of the imprinted genes in mouse: Grb10 and Dlk1

    Author: Madon, M., 30 Mar 2012

    Supervisor: Ward, A. (Supervisor) & Chalmers, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File