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Personal profile

Research interests

My main interests are to understand:

(i) how fetal growth is regulated such that a body of correct size and proportions is attained

(ii) how altered fetal growth can influence health in later life, including predisposition to cancer, obesity and diabetes.

These are big questions, relevant to important medical problems. Our approach has been to focus on a small group of genes regulated by genomic imprinting. Imprinted genes behave unusually in that they are expressed predominantly, if not exclusively, from only one of their two parental copies. Although only about 100 imprinted genes are known, a large proportion of them regulate fetal growth and/or adult physiology, with others influencing brain function and behaviour.

The Grb10 gene is expressed from the maternally-inherited copy in most fetal tissues outside of the central nervous system and we have shown that it acts to inhibit growth of both the embryo and placenta. In adult life the maternally-inherited Grb10 allele regulates insulin receptor signalling and body fat deposition and can, therefore, directly influence energy homeostasis. Recently, we found that in the brain Grb10 is expressed mainly from the paternal allele and we have discovered that this brain expression is linked with the control of social dominance behaviour. By gaining a deeper understanding of the different functions of Grb10 we aim to understand why this and other imprinted genes have evolved.

Current lab members

  • Xiao Hu
  • Kim Moorwood
  • Sasi Saminathan 

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  • 3 Similar Profiles
Insulin-Like Growth Factor II Medicine & Life Sciences
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Growth Medicine & Life Sciences
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Projects 2004 2022

MRC adipose regulation

Ward, A. & Moorwood, K.

3/01/192/01/22

Project: Research council

Health
Mothers
Genes
Diet
Obesity
pleiotropy
trajectories
genome
adult development
artificial selection

Research Output 1988 2018

4 Citations (Scopus)

Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior

Dent, C. L., Humby, T., Lewis, K., Ward, A., Fischer-Colbrie, R., Wilkinson, L. S., Wilkins, J. F. & Isles, A. R., 1 May 2018, In : Genetics. 209, 1, p. 233-239

Research output: Contribution to journalArticle

Open Access
100 Citations (Scopus)

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Goodson, W. H., Lowe, L., Carpenter, D. O., Gilbertson, M., Manaf Ali, A., Lopez de Cerain Salsamendi, A., Lasfar, A., Carnero, A., Azqueta, A., Amedei, A., Charles, A. K., Collins, A. R., Ward, A., Salzberg, A. C., Colacci, A., Olsen, A-K., Berg, A., Barclay, B. J., Zhou, B. P., Blanco-Aparicio, C. & 153 othersBaglole, C. J., Dong, C., Mondello, C., Hsu, C-W., Naus, C. C., Yedjou, C., Curran, C. S., Laird, D. W., Koch, D. C., Carlin, D. J., Felsher, D. W., Roy, D., Brown, D. G., Ratovitski, E., Ryan, E. P., Corsini, E., Rojas, E., Moon, E-Y., Laconi, E., Marongiu, F., Al-Mulla, F., Chiaradonna, F., Darroudi, F., Martin, F. L., Van Schooten, F. J., Goldberg, G. S., Wagemaker, G., Nangami, G. N., Calaf, G. M., Williams, G., Wolf, G. T., Koppen, G., Brunborg, G., Lyerly, H. K., Krishnan, H., Ab Hamid, H., Yasaei, H., Sone, H., Kondoh, H., Salem, H. K., Hsu, H-Y., Park, H. H., Koturbash, I., Miousse, I. R., Scovassi, A. I., Klaunig, J. E., Vondráček, J., Raju, J., Roman, J., Wise, J. P., Whitfield, J. R., Woodrick, J., Christopher, J. A., Ochieng, J., Martinez-Leal, J. F., Weisz, J., Kravchenko, J., Sun, J., Prudhomme, K. R., Narayanan, K. B., Cohen-Solal, K. A., Moorwood, K., Gonzalez, L., Soucek, L., Jian, L., D'Abronzo, L. S., Lin, L-T., Li, L., Gulliver, L., McCawley, L. J., Memeo, L., Vermeulen, L., Leyns, L., Zhang, L., Valverde, M., Khatami, M., Romano, M. F., Chapellier, M., Williams, M. A., Wade, M., Manjili, M. H., Lleonart, M. E., Xia, M., Gonzalez, M. J., Karamouzis, M. V., Kirsch-Volders, M., Vaccari, M., Kuemmerle, N. B., Singh, N., Cruickshanks, N., Kleinstreuer, N., van Larebeke, N., Ahmed, N., Ogunkua, O., Krishnakumar, P. K., Vadgama, P., Marignani, P. A., Ghosh, P. M., Ostrosky-Wegman, P., Thompson, P. A., Dent, P., Heneberg, P., Darbre, P., Sing Leung, P., Nangia-Makker, P., Cheng, Q. S., Robey, R. B., Al-Temaimi, R., Roy, R., Andrade-Vieira, R., Sinha, R. K., Mehta, R., Vento, R., Di Fiore, R., Ponce-Cusi, R., Dornetshuber-Fleiss, R., Nahta, R., Castellino, R. C., Palorini, R., Abd Hamid, R., Langie, S. A. S., Eltom, S. E., Brooks, S. A., Ryeom, S., Wise, S. S., Bay, S. N., Harris, S. A., Papagerakis, S., Romano, S., Pavanello, S., Eriksson, S., Forte, S., Casey, S. C., Luanpitpong, S., Lee, T-J., Otsuki, T., Chen, T., Massfelder, T., Sanderson, T., Guarnieri, T., Hultman, T., Dormoy, V., Odero-Marah, V., Sabbisetti, V., Maguer-Satta, V., Rathmell, W. K., Engström, W., Decker, W. K., Bisson, W. H., Rojanasakul, Y., Luqmani, Y., Chen, Z. & Hu, Z., Jun 2015, In : Carcinogenesis. 36 Suppl 1, p. S254-S296

Research output: Contribution to journalArticle

Open Access
Carcinogenesis
Neoplasms
Chemical Safety
Research
International Agencies
1 Citation (Scopus)

Coadaptation between mother and offspring: why not?

Wolf, J. B., Cowley, M. & Ward, A., 18 Mar 2015, In : PLoS Biology. 13, 3, e1002085.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

Ferrón, S. R., Radford, E. J., Domingo-Muelas, A., Kleine, I., Ramme, A., Gray, D., Sandovici, I., Constancia, M., Ward, A., Menheniott, T. R. & Ferguson-Smith, A. C., 15 Sep 2015, In : Nature Communications. 6, 8265.

Research output: Contribution to journalArticle

Genomic Imprinting
stem cells
Lateral Ventricles
Neurogenesis
Stem cells
1 Citation (Scopus)

Psg22 expression in mouse trophoblast giant cells is associated with gene inversion and co-expression of antisense long non-coding RNAs

Williams, J. M., Ball, M., Ward, A. & Moore, T., 1 Jan 2015, In : Human Reproduction. 149, p. 125-137 13 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Antisense RNA
Trophoblasts
Giant Cells
Pregnancy

Thesis

Characterisation in mice of a conserved sequence, Mcr2, associated with the Wilms' tumour 1 (Wt1) locus

Author: Meza Menchaca, T., 1 Sep 2010

Supervisor: Ward, A. (Supervisor) & Moorwood, K. (Supervisor)

Student thesis: Doctoral ThesisPhD

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