Projects per year
Personal profile
Research interests
My main interests are to understand:
(i) how fetal growth is regulated such that a body of correct size and proportions is attained
(ii) how altered fetal growth can influence health in later life, including predisposition to cancer, obesity and diabetes.
These are big questions, relevant to important medical problems. Our approach has been to focus on a small group of genes regulated by genomic imprinting. Imprinted genes behave unusually in that they are expressed predominantly, if not exclusively, from only one of their two parental copies. Although only about 100 imprinted genes are known, a large proportion of them regulate fetal growth and/or adult physiology, with others influencing brain function and behaviour.
The Grb10 gene is expressed from the maternally-inherited copy in most fetal tissues outside of the central nervous system and we have shown that it acts to inhibit growth of both the embryo and placenta. In adult life the maternally-inherited Grb10 allele regulates insulin receptor signalling and body fat deposition and can, therefore, directly influence energy homeostasis. Recently, we found that in the brain Grb10 is expressed mainly from the paternal allele and we have discovered that this brain expression is linked with the control of social dominance behaviour. By gaining a deeper understanding of the different functions of Grb10 we aim to understand why this and other imprinted genes have evolved.
Current lab members
- Xiao Hu
- Kim Moorwood
- Sasi Saminathan
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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BrainHealth - Decoding life course pathways of mental ageing - Frontier Research Guarantee
1/10/23 → 30/09/28
Project: EU Commission
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Multi User High-Content Confocal Microscope
Sero, J., Cevik, V., Gurevich, D., Jungwirth, U., Kelsh, R., Koumanov, F., Kyprianou, A., Laabei, M., Licchesi, J., Murrell, A., Pascu, S., Turner, L., Walko, G., Ward, A., Ward, S., Williams, R. & Zachariadis, M.
Biotechnology and Biological Sciences Research Council
1/08/22 → 31/07/23
Project: Research council
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Imprinted genes defining a novel mammalian growth regulatory axis
28/05/19 → 29/12/22
Project: Research council
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Mechanisms Underlying Developmental Programming of Lifelong Health
Wolf, J., Hurst, L. & Ward, A.
1/02/14 → 31/07/17
Project: Research council
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Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart
Prickett, A. R., Montibus, B., Barkas, N., Amante, S. M., Franco, M. M., Cowley, M., Puszyk, W., Shannon, M. F., Irving, M. D., Madon-Simon, M., Ward, A., Schulz, R., Baldwin, H. S. & Oakey, R. J., 22 Jun 2021, In: Frontiers in Cell and Developmental Biology. 9, 676543.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (SciVal) -
Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance
Rienecker, K. D. A., Chavasse, A. T., Moorwood, K., Ward, A. & Isles, A. R., 1 Jan 2020, In: Genes, Brain and Behavior. 19, 1, e12571.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (SciVal)33 Downloads (Pure) -
Mice lacking paternal expression of imprinted Grb10 are risk-takers
Dent, C. L., Rienecker, K. D. A., Ward, A., Wilkins, J. F., Humby, T. & Isles, A. R., 30 Sept 2020, In: Genes, Brain and Behavior. 19, 7, e12679.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (SciVal) -
Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior
Dent, C. L., Humby, T., Lewis, K., Ward, A., Fischer-Colbrie, R., Wilkinson, L. S., Wilkins, J. F. & Isles, A. R., 1 May 2018, In: Genetics. 209, 1, p. 233-239 7 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (SciVal) -
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
Goodson, W. H., Lowe, L., Carpenter, D. O., Gilbertson, M., Manaf Ali, A., Lopez de Cerain Salsamendi, A., Lasfar, A., Carnero, A., Azqueta, A., Amedei, A., Charles, A. K., Collins, A. R., Ward, A., Salzberg, A. C., Colacci, A., Olsen, A-K., Berg, A., Barclay, B. J., Zhou, B. P., Blanco-Aparicio, C., & 153 others , Jun 2015, In: Carcinogenesis. 36 Suppl 1, p. S254-S296Research output: Contribution to journal › Article › peer-review
Open Access219 Citations (SciVal)