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Andrew Thompson

Dr

  • 5 WEST 2.15

20002017
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Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 6 Similar Profiles
Tankyrases Chemical Compounds
Poly(ADP-ribose) Polymerases Medicine & Life Sciences
Cyclization Chemical Compounds
Molecular modeling Chemical Compounds
Acids Chemical Compounds
1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione) Chemical Compounds
Coenzyme A Chemical Compounds
Esters Chemical Compounds

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Projects 2008 2017

Research Output 2000 2017

Development of scalable graphene-based electronics for sensing applications

Stephenson, J. 2017 81 p.

Research output: ThesisDoctoral Thesis

Open Access
File
Graphite
Electronic equipment
Fabrication
Copper
Atomic force microscopy
7 Citations

Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases

Nathubhai, A., Haikarainen, T., Hayward, P. C., Munoz-Descalzo, S., Thompson, A. S., Lloyd, M. D., Lehtio, L. & Threadgill, M. 8 Aug 2016 In : European Journal of Medicinal Chemistry. 118, p. 316-327

Research output: Contribution to journalArticle

Open Access
File
Tankyrases
Structure-Activity Relationship
Poly(ADP-ribose) Polymerases
Molecular Probes
Pharmaceutical Preparations
12 Citations

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. & Threadgill, M. D. 1 Sep 2015 In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5891-5908 18 p.

Research output: Contribution to journalArticle

File
Tankyrases
Benzamides
Deprotonation
Molecular modeling
Niacinamide
1 Citations

Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems

Twum, E. A., Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. & Threadgill, M. D. 1 Jul 2015 In : Bioorganic and Medicinal Chemistry. 23, 13, p. 3481-3489

Research output: Contribution to journalArticle

File
Cyclization
Prodrugs
Cytotoxicity
Cells
Allylation
16 Citations

Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases

Kumpan, K., Nathubhai, A., Zhang, C., Wood, P. J., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Lehtio, L. & Threadgill, M. D. 1 Jul 2015 In : Bioorganic and Medicinal Chemistry. 23, p. 3013-3032

Research output: Contribution to journalArticle

File
Tankyrases
Derivatives
Benzamidines
Adenosine Diphosphate
Acids