• 3 SOUTH 1.16

1994 …2021
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Personal profile

Research interests

Research in the group is in the broad area of bacterial pathogenesis. In particular our work is focused on the genus Bordetella. This group includes important pathogens of humans and animal, notably the main causative agent of Whooping Cough, B. pertussis. It also includes non-pathogenic, environmental species and some species for which the reservoirs are unclear and their true pathogenic nature is unknown.

Our studies encompass fundmental investigations of bacterial factors important to the infection biology of these bacteria, with an emphasis on surface polysaccharides such as lipopolysaccharide (LPS); more applied projects such as defining Bordetella metabolism with the aim of improving in vitro culture processes for vaccine production and elucidation of the evolutionary relationships between these and other bacteria.

Infection Biology

We have defined structure function relationships for many of the different regions of Bordetella LPS, including the role of the Band A trisaccharide and O polysaccharide in infection and immunity. We continue to investigate the genetic basis for LPS biosynthesis among the Bordetella and use this information to make defined genetic mutants whose phenotypes reveal the role of particular structures in infection.

Collaborators: Dr Eric Harvill, Penn State University, USA; Dr Bob Ernst, University of Baltimore-Maryland, USA.

Metabolism

We are generating genome-scale metabolic models for B. pertussis metabolism with the aim of improving on current culture methods for use in biotechnology and vaccine production. This work combines mathematical modeling with wet lab studies, in cycles of model validation and refinement.

Collaborators: Dr Caroline Colijn, Imperial College, London; Dr Philippe Dehottay & Dr Philippe Goffin, GSK Biologicals, Rixensaart, Belgium.

Evolution

We have a long standing involvement of generating and analysing genome sequences for the bordetellae. We are currently involved in a large scale analysis of the global population structure of B. pertussis, focused analysis of current UK B. pertussis strains and evolutionary relationships between all members of the genus.

Collaborators: Simon Harris & Julian Parkhill, Sanger Institute, Hinxton, UK; Dr Eric Harvill, Penn State University, USA.

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Lipopolysaccharides Medicine & Life Sciences
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Projects 2012 2021

Whooping Cough
Pertussis Vaccine
Immunity
Animal Models
Biomarkers

Is the Circulating Bordetella pertussis Population Evolving to Evade Vaccine-induced Immunity

Preston, A.

1/09/1231/08/15

Project: Central government, health and local authorities

Bordetella pertussis
Systems Biology
Genome
Growth
Bacteria

Research Output 1994 2019

The evolution of Bordetella pertussis has selected for mutations of acr that lead to sensitivity to hydrophobic molecules and fatty acids.

MacArthur, I., Belcher, T., King, J., Ramasamy, V., Alhammadi, M. & Preston, A., 10 Apr 2019, In : Emerging Microbes and Infections. 10 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Bordetella pertussis isolates vary in their interactions with human complement components article

Brookes, C., Freire-Martin, I., Cavell, B., Alexander, F., Taylor, S., Persaud, R., Fry, N., Preston, A., Diavatopoulos, D. & Gorringe, A., 1 Dec 2018, In : Emerging Microbes and Infections. 7, 1, 81.

Research output: Contribution to journalArticle

Open Access
Complement C1 Inhibitor Protein
Bordetella pertussis
Complement C3b
Complement Membrane Attack Complex
Whooping Cough
Open Access

Resolving the complex Bordetella pertussis genome using barcoded nanopore sequencing

Ring, N., Abrahams, J. S., Jain, M., Olsen, H., Preston, A. & Bagby, S., 28 Nov 2018, In : Microbial Genomics. 4, 11, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access

Thesis

Investigating the growth and metabolic difference of Bvg+ and Bvg- phase Bordetella pertussis

Author: Belcher, T., 16 Nov 2017

Supervisor: Preston, A. (Supervisor)

Student thesis: Doctoral ThesisPhD

Is the circulating UK Bordetella pertussis population evolving to evade vaccine-induced immunity?

Author: Sealey, K., 29 Jun 2016

Supervisor: Preston, A. (Supervisor), Gorringe, A. R. (External person) (Supervisor) & Fry, N. K. (External person) (Supervisor)

Student thesis: Doctoral ThesisPhD

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