Andrew Chalmers

Dr

  • 4 SOUTH 0.44

Accepting PhD Students

19982018
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Research Output 1998 2018

Neurogenesis
Xenopus
Phosphotransferases
Cell Proliferation
Cell Polarity
15 Citations (Scopus)
22 Downloads (Pure)

A dual role for the βPS integrin myospheroid in mediating Drosophila embryonic macrophage migration

Comber, K., Huelsmann, S., Evans, I., Sánchez-Sánchez, B. J., Chalmers, A., Reuter, R., Wood, W. & Martín-Bermudo, M. D., 1 Aug 2013, In : Journal of Cell Science. 126, 15, p. 3475-3484 10 p.

Research output: Contribution to journalArticle

Open Access
Hemocytes
Integrins
Drosophila
Macrophages
Embryonic Structures
101 Citations (Scopus)

aPKC, Crumbs3 and Lgl2 control apicobasal polarity in early vertebrate development

Chalmers, A. D., Pambos, M., Mason, J., Lang, S., Wylie, C. & Papalopulu, N., 2005, In : Development. 132, 5, p. 977-986 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
29 Downloads (Pure)

A subset of high Gleason grade prostate carcinomas contain a large burden of prostate cancer syndecan-1 positive stromal cells

Sharpe, B., Alghezi, D. A., Cattermole, C., Beresford, M., Bowen, R., Mitchard, J. & Chalmers, A. D., 15 Sep 2017, In : Prostate. 77, 13, p. 1312-1324 13 p., 23391.

Research output: Contribution to journalArticle

Open Access
File
Syndecan-1
Stromal Cells
Prostate
Prostatic Neoplasms
Carcinoma
34 Citations (Scopus)

A Xenopus tropicalis oligonucleotide microarray works across species using RNA from Xenopus laevis

Chalmers, A. D., Goldstone, K., Smith, J. C., Gilchrist, M., Amaya, E. & Papalopulu, N., 2005, In : Mechanisms of Development. 122, 3, p. 355-363 9 p.

Research output: Contribution to journalArticle

Bmp4 promotes differentiation of the first vertebrate epithelium

Wei, J., Sanchez Ripoll, Y., Welham, M. & Chalmers, A. D., 2009, In : Mechanisms of Development. 126, Suppl S, p. S271

Research output: Contribution to journalArticle

Vertebrates
Epithelium
Epithelial Cells
Xenopus
Embryonic Structures
7 Citations (Scopus)

Cell surface dynamics and cellular distribution of endogenous FcRn

D'Hooghe, L., D Chalmers, A., Heywood, S. & Whitley, P., 17 Aug 2017, In : PLoS ONE. 12, 8, e0182695.

Research output: Contribution to journalArticle

Open Access
Immunoglobulin G
Endocytosis
endocytosis
recycling
albumins
13 Citations (Scopus)
98 Downloads (Pure)

CiteAb: A searchable antibody database that ranks antibodies by the number of times they have been cited

Helsby, M. A., Leader, P. M., Fenn, J. R., Gulsen, T., Bryant, C., Doughton, G., Sharpe, B., Whitley, P., Caunt, C. J., James, K., Pope, A. D., Kelly, D. H. & Chalmers, A. D., 14 Feb 2014, In : BMC Cell Biology. 15, 1, p. 1-12 12 p., 6.

Research output: Contribution to journalArticle

Open Access
Databases
Antibodies
Publications
Research Personnel
Research

CiteAb and Antibody Validation

Chalmers, A., Oct 2014.

Research output: Contribution to conferencePaper

16 Citations (Scopus)
102 Downloads (Pure)

Continuous endocytic recycling of tight junction proteins: how and why?

Chalmers, A. & Whitley, P., 2012, In : Essays in Biochemistry. 53, p. 41-54 14 p.

Research output: Contribution to journalArticle

Open Access
File
Tight Junction Proteins
Tight Junctions
Recycling
Protein Transport
Endocytosis
79 Citations (Scopus)

Development of the gut in Xenopus laevis.

Chalmers, A. & Slack, J., Dec 1998, In : Developmental Dynamics. 212, 4, p. 509-521 13 p.

Research output: Contribution to journalArticle

167 Citations (Scopus)

Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo

Plusa, B., Frankenberg, S., Chalmers, A., Hadjantonakis, A. K., Moore, C. A., Papalopulu, N., Papaioannou, V. E., Glover, D. M. & Zernicka-Goetz, M., 2005, In : Journal of Cell Science. 118, 3, p. 505-515 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis

Hill, V. K., Underhill-Day, N., Krex, D., Robel, K., Sangan, C. B., Summersgill, H. R., Morris, M., Gentle, D., Chalmers, A. D., Maher, E. R. & Latif, F., Feb 2011, In : Oncogene. 30, 8, p. 978-989 12 p.

Research output: Contribution to journalArticle

Astrocytoma
Tumor Suppressor Genes
Epigenomics
Glioma
Glioblastoma

Expression of SALL4 in prostate cancer

Chalmers, A. & Alghezi, D., 31 Jul 2018, In : Cancer Research. 78, 13 Supplement, 1 p., 2637.

Research output: Contribution to journalMeeting abstract

60 Citations (Scopus)

FGF-8 stimulates neuronal differentiation through FGFR-4a and interferes with mesoderm induction in Xenopus embryos

Hardcastle, Z., Chalmers, A. & Papalopulu, N., Nov 2000, In : Current Biology. 10, 23, p. 1511-1514 4 p.

Research output: Contribution to journalArticle

Formation and Maintenance of Differentiated Epithelial Cells

Chalmers, A., 2012.

Research output: Contribution to conferencePaper

6 Citations (Scopus)
46 Downloads (Pure)

Formation of a polarised primitive endoderm layer in embryoid bodies requires Fgfr/Erk signalling

Doughton, G., Wei, J., Tapon, N., Welham, M. J. & Chalmers, A. D., 21 Apr 2014, In : PLoS ONE. 9, 4, e95434.

Research output: Contribution to journalArticle

Open Access
Embryoid Bodies
Endoderm
Polarization
cells
receptors
39 Citations (Scopus)
83 Downloads (Pure)

Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells

Dukes, J. D., Fish, L., Richardson, J. D., Blaikley, E., Burns, S., Caunt, C. J., Chalmers, A. D. & Whitley, P., 1 Sep 2011, In : Molecular Biology of the Cell. 22, 17, p. 3192-3205 14 p.

Research output: Contribution to journalArticle

Open Access
Endosomal Sorting Complexes Required for Transport
Claudin-1
Recycling
Vertebrates
Epithelial Cells
39 Citations (Scopus)
105 Downloads (Pure)

Grainyhead-like 3, a transcription factor identified in a microarray screen, promotes the specification of the superficial layer of the embryonic epidermis

Chalmers, A., Lachani, K., Shin, Y., Sherwood, V., Cho, K. & Papalopulu, N., Sep 2006, In : Mechanisms of Development. 123, 9, p. 702-718 17 p.

Research output: Contribution to journalArticle

File
Transcription Factor 3
Epidermis
Ectoderm
Gastrula
Genes
21 Citations (Scopus)
73 Downloads (Pure)

Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis

Recino, A., Sherwood, V., Flaxman, A., Cooper, WN., Latif, F., Ward, A. & Chalmers, A. D., 1 Sep 2010, In : Biochemical Journal. 430, 2, p. 207-213 7 p.

Research output: Contribution to journalArticle

Open Access
Cytoskeleton
Mitosis
Microtubules
Chemical activation
Cells
74 Citations (Scopus)

Intrinsic differences between the superficial and deep layers of the Xenopus ectoderm control primary neuronal differentiation

Chalmers, A. D., Welchman, D. & Papalopulu, N., 2002, In : Developmental Cell. 2, 2, p. 171-182 12 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Oriented cell divisions asymmetrically segregate aPKC and generate cell fate diversity in the early Xenopus embryo

Chalmers, A. D., Strauss, B. & Papalopulu, N., 2003, In : Development. 130, 12, p. 2657-2668 12 p.

Research output: Contribution to journalArticle

Primary neuronal differentiation and orientated cell division in Xenopus

Chalmers, A. D., Strauss, B. & Papalopulu, N., 2001, In : Developmental Biology. 235, 1, p. 216-216 1 p.

Research output: Contribution to journalArticle

RASSF7: a new possible therapeutic cancer target?

Recino, A., Flaxman, A., Sherwood, V., Cooper, W., Ward, A., Latif, F. & Chalmers, A. D., Feb 2010, In : Genetics Research. 92, 1, p. 71-72 2 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
78 Downloads (Pure)

RASSF7 is a member of a new family of RAS association domain- containing proteins and is required for completing mitosis

Sherwood, V., Manbodh, R., Sheppard, C. & Chalmers, A. D., 1 Apr 2008, In : Molecular Biology of the Cell. 19, 4, p. 1772-1782 11 p.

Research output: Contribution to journalArticle

Open Access
Mitosis
Neural Tube
Centrosome
Proteins
Spindle Apparatus

RASSF7 regulates microtubules during mitosis

Chalmers, A., 2011.

Research output: Contribution to conferencePaper

RASSF7 Regulates Microtubules During Mitosis

Chalmers, A., 2010.

Research output: Contribution to conferencePaper

27 Citations (Scopus)

Regional gene expression in the epithelia of the Xenopus tadpole gut

Chalmers, A., Slack, J. & Beck, C., Aug 2000, In : Mechanisms of Development. 96, 1, p. 125-128 4 p.

Research output: Contribution to journalArticle

Xenopus
Larva
Epithelium
Homeobox Genes
Gene Expression
18 Citations (Scopus)
93 Downloads (Pure)

Reporting research antibody use: How to increase experimental reproducibility

Helsby, M., Fenn, J. & Chalmers, A., 2013, In : F1000 Research. 2, 153 v2.

Research output: Contribution to journalArticle

Open Access
File
Antibodies
Research
Publications
Research Personnel
Biological Science Disciplines
272 Citations (Scopus)

Reproducibility: Standardize antibodies used in research

Chalmers, A. & Bradbury, A., Feb 2015, In : Nature. 518, 7537, p. 27 - 29 3 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
120 Downloads (Pure)

Searching for prostate cancer stem cells: markers and methods

Sharpe, B., Beresford, M., Bowen, R., Mitchard, J. & Chalmers, A. D., Oct 2013, In : Stem Cell Reviews and Reports. 9, 5, p. 721-730

Research output: Contribution to journalArticle

Open Access
File
Neoplastic Stem Cells
Prostatic Neoplasms
Colony-Forming Units Assay
Neoplasms
Transgenic Mice
37 Citations (Scopus)

The apicobasal polarity kinase aPKC functions as a nuclear determinant and regulates cell proliferation and fate during Xenopus primary neurogenesis

Sabherwal, N., Tsutsui, A., Hodge, S., Wei, J., Chalmers, A. D. & Papalopulu, N., 15 Aug 2009, In : Development. 136, 16, p. 2767-2777 11 p.

Research output: Contribution to journalArticle

Neurogenesis
Xenopus
Phosphotransferases
Cell Proliferation
Cell Polarity
4 Citations (Scopus)
94 Downloads (Pure)

The F1000Research Antibody Validation Article Collection

Helsby, M. A., Leung, M. Y. & Chalmers, A. D., 11 Nov 2014, In : F1000 Research. 3, 241

Research output: Contribution to journalArticle

Open Access
File
Antibodies
Validation Studies
Biological Science Disciplines
Research Personnel
98 Citations (Scopus)
72 Downloads (Pure)

The MDCK variety pack: choosing the right strain

Dukes, J. D., Whitley, P. & Chalmers, A. D., 7 Oct 2011, In : BMC Cell Biology. 12, 43.

Research output: Contribution to journalArticle

Open Access
File
Madin Darby Canine Kidney Cells
Research Personnel
Adherens Junctions
Directories
Desmosomes
79 Citations (Scopus)
75 Downloads (Pure)

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias

Hesson, L. B., Dunwell, T. L., Cooper, W. N., Catchpoole, D., Brini, A. T., Chiaramonte, R., Griffiths, M., Chalmers, A. D., Maher, E. R. & Latif, F., 1 Jul 2009, In : Molecular Cancer. 8, 42

Research output: Contribution to journalArticle

File
Tumor Suppressor Genes
Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-Cell Leukemia
Methylation
63 Citations (Scopus)
121 Downloads (Pure)

The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formation

Sherwood, V., Recino, A., Jeffries, A., Ward, A. & Chalmers, A. D., 2010, In : Biochemical Journal. 425, 2, p. 303-311 9 p.

Research output: Contribution to journalReview article

File
Association reactions
Neoplasms
Proteins
Tumors
Protein Domains
30 Citations (Scopus)
70 Downloads (Pure)
Open Access
File
Claudin-2
Zonula Occludens-1 Protein
Claudin-1
Tight Junction Proteins
Madin Darby Canine Kidney Cells
49 Citations (Scopus)

The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways

Lock, F. E., Underhill-Day, N., Dunwell, T., Matallanas, D., Cooper, W., Hesson, L., Recino, A., Ward, A., Pavlova, T., Zabarovsky, E., Grant, M. M., Maher, E. R., Chalmers, A. D., Kolch, W. & Latif, F., 2010, In : Oncogene. 29, 30, p. 4307-4316 10 p.

Research output: Contribution to journalArticle

Wnt Proteins
beta Catenin
Adherens Junctions
Growth
Cadherins
100 Citations (Scopus)

The Xenopus Tadpole gut: fate maps and morphogenetic movements

Chalmers, A. & Slack, J., 15 Jan 2000, In : Development. 127, p. 381-392 12 p.

Research output: Contribution to journalArticle

Endoderm
Xenopus
Gastrula
Larva
Smooth Muscle

Tight Junction Recycling

Chalmers, A., 2011.

Research output: Contribution to conferencePaper

1 Citation (Scopus)
95 Downloads (Pure)

Truncated RASSF7 promotes centrosomal defects and cell death

Gulsen, T., Hadjicosti, I., Li, Y., Zhang, X., Whitley, P. R. & Chalmers, A. D., 15 Jan 2016, In : Developmental Biology. 409, 2, p. 502-517 16 p.

Research output: Contribution to journalArticle

Open Access
File
Centrosome
Cell Death
Proteins
Tubulin
Oncogenes