Andrew Chalmers

Dr

  • 4 SOUTH 0.44

Accepting PhD Students

19982017
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Personal profile

Research interests

Our research focuses on understanding the behaviour of epithelial cells in normal tissues and during tumour formation, with recent work focusing on examining the expression of stem cell regulators in prostate cancer.

I also have a strong interest in improving the use and reliability of research antibodies. I founded and am the Chief Scientific Officer of the spin out company CiteAb (www.citeab.com). CiteAb runs a citation based antibody search engine which aims to provide a better way for researchers to find antibodies which are suitable for their experiments. I have also contributed to a number of initiatives aimed at improving antibody validation, for example I am a founding guest editor of the F1000Research Antibody Validation Channel, which hosts a collection of primary papers, reviews and comment articles which focus on antibody validation.

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Recycling Medicine & Life Sciences
Tight Junction Proteins Chemical Compounds
Epithelium Medicine & Life Sciences
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Mitosis Medicine & Life Sciences
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Epithelial Cells Medicine & Life Sciences
Centrosome Medicine & Life Sciences

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Projects 2005 2016

University of Bath 50th Anniversary Conference Funding

Chalmers, A.

1/01/1630/09/16

Project: Research-related fundingScientific event

Annett Trust PhD Studentship- 3 month extension

Chalmers, A.

1/10/1531/12/15

Project: UK charityIndividual grant

Structure and function of RASSF7, both tumour suppressor and oncogene?

Bagby, S. & Chalmers, A.

1/07/131/04/14

Project: Research-related fundingInternally Funded Research

Research Output 1998 2017

3 Citations (Scopus)

A subset of high Gleason grade prostate carcinomas contain a large burden of prostate cancer syndecan-1 positive stromal cells

Sharpe, B., Alghezi, D. A., Cattermole, C., Beresford, M., Bowen, R., Mitchard, J. & Chalmers, A. D., 15 Sep 2017, In : Prostate. 77, 13, p. 1312-1324 13 p., 23391.

Research output: Contribution to journalArticle

Open Access
File
Syndecan-1
Stromal Cells
Prostate
Prostatic Neoplasms
Carcinoma
3 Citations (Scopus)

Cell surface dynamics and cellular distribution of endogenous FcRn

D'Hooghe, L., D Chalmers, A., Heywood, S. & Whitley, P., 17 Aug 2017, In : PLoS ONE. 12, 8, e0182695.

Research output: Contribution to journalArticle

Open Access
Immunoglobulin G
Endocytosis
endocytosis
recycling
albumins
1 Citation (Scopus)

Truncated RASSF7 promotes centrosomal defects and cell death

Gulsen, T., Hadjicosti, I., Li, Y., Zhang, X., Whitley, P. R. & Chalmers, A. D., 15 Jan 2016, In : Developmental Biology. 409, 2, p. 502-517

Research output: Contribution to journalArticle

Open Access
File
Centrosome
Cell Death
Proteins
Tubulin
Oncogenes
236 Citations (Scopus)

Reproducibility: Standardize antibodies used in research

Chalmers, A. & Bradbury, A., Feb 2015, In : Nature. 518, 7537, p. 27 - 29 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

CiteAb: A searchable antibody database that ranks antibodies by the number of times they have been cited

Helsby, M. A., Leader, P. M., Fenn, J. R., Gulsen, T., Bryant, C., Doughton, G., Sharpe, B., Whitley, P., Caunt, C. J., James, K., Pope, A. D., Kelly, D. H. & Chalmers, A. D., 14 Feb 2014, In : BMC Cell Biology. 15, 1, 6.

Research output: Contribution to journalArticle

Open Access
File
Databases
Antibodies
Publications
Research Personnel
Research

Thesis

Modulation of tight junction composition by the ERK pathway

Author: Bryant, C., 6 Jun 2015

Supervisor: Caunt, C. (Supervisor), Chalmers, A. (Supervisor) & Whitley, P. (Supervisor)

Student thesis: Doctoral ThesisPhD

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