• 7 WEST 3.10

Accepting PhD Students

20012020
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Research Output 2001 2018

  • 18 Article
  • 5 Patent
  • 4 Meeting abstract
  • 1 Conference contribution
2018
11 Citations (Scopus)
15 Downloads (Pure)

De novo mutations in GRIN1 cause extensive bilateral polymicrogyria

Mackenzie, A., Fry, A., Thomposon, B., Fawcett, K., Zelnik, N., Shemer-Meiri, L., cushion, T., Mugalaasi, H. & Stoodley, N., 31 Mar 2018, In : Brain : A Journal of Neurology. 141, 3, p. 698-712 15 p.

Research output: Contribution to journalArticle

Open Access
Mutation
N-Methyl-D-Aspartate Receptors
Missense Mutation
Exome
Polymicrogyria
8 Citations (Scopus)
23 Downloads (Pure)
Open Access
File
Peroxynitrous Acid
Macrophages
Reactive Oxygen Species
Fluorescence
Oxidative stress
1 Citation (Scopus)
164 Downloads (Pure)
Open Access
File
Inflammasomes
Lipopolysaccharides
Inflammation
Illness Behavior
Depression
2016
83 Downloads (Pure)

Editorial: roles of ion channels in immune cells

Stokes, L., MacKenzie, A. B. & Sluyter, R., 15 Feb 2016, In : Frontiers in Immunology. 7, 48.

Research output: Contribution to journalArticle

Open Access
File

The profile of P2X7 receptor expression and properties in polarized primary mouse microglia cultures

Jackson, M., Wickens, R., Bailey, S. & Mackenzie, A., 2016, In : Journal of Psychopharmacology . 30, Abstract Supplement to volume 8, p. A98

Research output: Contribution to journalMeeting abstract

Purinergic P2X7 Receptors
Microglia
Lipopolysaccharides
Ethidium
Adenosine Triphosphate
2015

Primary microglia isolated from neonatal mice provide a model for the study of NLRP3 inflammasome and the effect of long-term hypoxia

Wickens, R., Ver Donck, L., Bailey, S. & Mackenzie, A., 2015, Neuroscience Meeting Planner: Society for Neuroscience. 809.29

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Inflammasomes
Microglia
Caspase 1
Adenosine Triphosphate
Brain
18 Downloads (Pure)

The effect of housing conditions on lipopolysaccharide-induced depressive-like behaviour in mice

Wickens, R., Ver Donck, L., Mackenzie, A. & Bailey, S., Aug 2015, In : Journal of Psychopharmacology . 29, 8 (Abstract Supplement), p. A17 A08.

Research output: Contribution to journalMeeting abstract

Open Access
File
2014

Acute And Chronic Lipopolysaccharide Induces Sickness But Fails To Produce A Depressive-Like Behaviour In Mice

Wickens, R., Ver Donck, L., Mackenzie, A. & Bailey, S. J., Aug 2014, In : Journal of Psychopharmacology . 28, 8, p. A107

Research output: Contribution to journalMeeting abstract

6 Citations (Scopus)

Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naïve human CD4+ T lymphocytes

Foster, J. G., Carter, E., Kilty, I., Mackenzie, A. B. & Ward, S. G., 15 Feb 2013, In : The Journal of Immunology. 190, 4, p. 1551-1559 9 p.

Research output: Contribution to journalArticle

Superoxides
Phosphatidylserines
Adenosine Triphosphate
T-Lymphocytes
Down-Regulation
2012
33 Citations (Scopus)

A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells

Thompson, B. A. N., Storm, M. P., Hewinson, J., Hogg, S., Welham, M. J. & Mackenzie, A. B., Mar 2012, In : Cellular Signalling. 24, 3, p. 770-778 9 p.

Research output: Contribution to journalArticle

Purinergic P2X7 Receptors
Embryonic Stem Cells
Cell Survival
Adenosine Triphosphate
Pluripotent Stem Cells

Functionalising reagents and their uses

Watts, A., Kantner, T. & Mackenzie, A., 11 Jan 2012, Patent No. CN102317305 (A)

Research output: Patent

Glycols
Sulfhydryl Compounds
Polysaccharides
Peptides
Molecules

Materials and methods relating to glycosylation

Watts, A., Kantner, T. & Mackenzie, A., 25 Apr 2012, IPC No. A61K47/48, Patent No. EP2442831 (A2)

Research output: Patent

Glycosylation
N-Acetylneuraminic Acid
Sugars
Fluorine
Carbohydrates
2011

Thiol-Functionalising Reagents and Their Uses

Watts, A., Kantner, T. & Mackenzie, A., 12 Oct 2011, IPC No. C07K1/13, Patent No. EP2373675 (A2)

Research output: Patent

Sulfhydryl Compounds
Glycols
Polysaccharides
Peptides
Molecules
2010

Expression of ATP-gated P2X7 receptors in mouse embryonic stem cells

Mackenzie, A., Welham, M. & Thompson, B., 2010, In : Purinergic Signalling. 6, Supplement 1, p. 129 1 p., P13-9.

Research output: Contribution to journalArticle

Materials and Methods Relating to Glycosylation

Watts, A., Mackenzie, A. & Kantner, T., 23 Dec 2010, IPC No. A61K47/48, Patent No. CA2768155 (A1)

Research output: Patent

Glycosylation
N-Acetylneuraminic Acid
Sugars
Fluorine
Carbohydrates

The role of protein kinase C and phosphoinositide 3-kinase in P2X7 receptor-mediated oxidation and IL-1beta processing

El Ouaaliti, M., Moore, S. F. & Mackenzie, A. B., Jun 2010, In : Purinergic Signalling. 6, 1, p. 49 1 p.

Research output: Contribution to journalArticle

2009

Detection and Functionalisation of S-Nitrosylated Polypeptides

Mackenzie, A. & Watts, A., 26 Feb 2009, IPC No. G01N33/68, Patent No. WO2009024791 (A1)

Research output: Patent

S-Nitrosothiols
Free radical reactions
Peptides
Labels
56 Citations (Scopus)

NADPH oxidase NOX2 mediates rapid vellular oxidation following ATP stimulation of endotoxin-primed macrophages

Moore, S. F. & Mackenzie, A. B., 1 Sep 2009, In : The Journal of Immunology. 183, 5, p. 3302-3308 7 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Endotoxins
Adenosine Triphosphate
Macrophages
Reactive Oxygen Species
2008
76 Citations (Scopus)

A key role for redox signaling in rapid P2X7 receptor-induced IL-1 β processing in human monocytes

Hewinson, J., Moore, S. F., Glover, C., Watts, A. & Mackenzie, A. B., 15 Jun 2008, In : The Journal of Immunology. 180, 12, p. 8410-8420 11 p.

Research output: Contribution to journalArticle

Caspase 1
Interleukin-1beta
NADPH Oxidase
Oxidation-Reduction
Monocytes
9 Citations (Scopus)

Species and agonist dependent zinc modulation of endogenous and recombinant ATP-gated P2X7 receptors

Moore, S. F. & Mackenzie, A. B., 15 Dec 2008, In : Biochemical Pharmacology. 76, 12, p. 1740-1747 8 p.

Research output: Contribution to journalArticle

Zinc
Adenosine Triphosphate
Modulation
Rats
Mutagenesis
2007
27 Citations (Scopus)

Murine macrophage P2X7 receptors support rapid prothrombotic responses

Moore, S. F. & Mackenzie, A. B., 2007, In : Cellular Signalling. 19, 4, p. 855-866 12 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Thrombin
Macrophages
Purinergic P2X7 Receptors
KN 62
2005

N -methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X 7 receptors

Jiang, L. H., Rassendren, F., Mackenzie, A. B., Zhang, Y. H., Surprenant, A. & North, R. A., 2005, In : American Journal of Physiology - Cell Physiology. 289, p. C1295-C1302

Research output: Contribution to journalArticle

112 Citations (Scopus)

Pseudoapoptosis induced by brief activation of ATP-gated P2X 7

Mackenzie, A. B., Young, M. T., Adolfini, E. & Surprenant, A., 2005, In : Journal of Biological Chemistry. 280, 40, p. 33968-33976 9 p.

Research output: Contribution to journalArticle

2003
42 Citations (Scopus)

Kv1.3 potassium channels in human alveolar macrophages

Mackenzie, A. B., Chirakkal, H. & North, R. A., 2003, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 285, p. L862-L868

Research output: Contribution to journalArticle

2002

Properties of Kv1.3 potassium channels in human lung macrophages

Mackenzie, A. B., Chirakkal, H. & North, R. A., 2002, In : The Journal of Physiology. 544, Suppl. S, p. 10P-11P

Research output: Contribution to journalArticle

2001
596 Citations (Scopus)

Rapid secretion of interleukin-1β by microvesicle shedding

Mackenzie, A. B., Wilson, H. L., Kiss-Toth, E., Dower, S. K., North, R. A. & Surprenant, A., 2001, In : Immunity. 8, p. 825-835 11 p.

Research output: Contribution to journalArticle