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Personal profile

Research interests

Our research focuses on understanding the mechanisms of inflammation and inflammatory disease.

Cell biology of immune cells

My research group is interested in innate immunity including macrophage and microglia inflammatory responses. In particular, we have an interest in molecular signalling pathways, including reactive oxygen species and the role of hypoxic regulation, underlying the activation of the NLRP3 inflammasome and the production of the inflammatory cytokine interleukin 1 (IL-1Beta).

The production of bioactive IL-1Beta is a tightly controlled multi-step process: first IL-1Beta is produced as an inactivate precursor 31 kD pro-IL-1Beta, this is cleaved to produce bioactive 17 kD IL-1Beta and then finally the bioactive IL-1Beta. The processing and cleavage of the IL-1Beta precursor is achieved by caspase-1 activated within a multi-protein complex termed the NLRP3 inflammasome. We have specific interest in the pathways leading to activation of the NLRP3 inflammasome activation in macrophages and microglia.

Sites of inflammation exist under hypoxic conditions where changes in oxygen levels alter the phenotype of cells and the inflammatory response.  The research group is interested in understanding how hypoxia regulates inflammatory responses, in particular inflammasome responses, compared to standard tissue culture conditions.  The Advanced Hypoxic facility was funded by the BBSRC ALERT14 equipment call.

Our research is funded by the EPSRC, BBSRC and the University of Bath.

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Projects

MRC P2D - Showcase Event

Mackenzie, A.

Medical Research Council

31/03/1831/10/18

Project: Research council

International Research Accelerator Scheme 2015-2016

Mackenzie, A., Zhang, B., Lou, X., Chen, Z., Bailey, S., Watson, M., Ward, S. & Jones, R.

1/06/1630/06/16

Project: Research-related funding

  • Research Output

    • 19 Article
    • 5 Patent
    • 4 Meeting abstract
    • 1 Conference contribution
    Open Access

    De novo mutations in GRIN1 cause extensive bilateral polymicrogyria

    Fry, A., Fawcett, K., Zelnik, N., Yuan, H., Thomposon, B., Shemer-Meiri, L., cushion, T., Mugalaasi, H., Sims, D., Stoodley, N., Chung, S-K., Rees, M. I., Patel, C. V., Brueton, L. A., Layet, V., Giuliano, F., Kerr, M. P., Banne, E., Meiner, V., Lerman-Sagie, T. & 21 others, Helbig, K. L., Kofman, L. H., Knight, K. M., Chen, W., Kannan, V., Hu, C., Kusumoto, H., Zhang, J., Swanger, S. A., Shaulsky, G. H., Mirzaa, G. M., Muir, A. M., Mefford, H. C., Dobyns, W. B., Mackenzie, A., Mullins, J. G. L., Lemke, J. R., Bahi-Buisson, N., Traynelis, S. F., Iago, H. F. & Pilz, D. T., 31 Mar 2018, In : Brain : A Journal of Neurology. 141, 3, p. 698-712 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 20 Citations (Scopus)
    15 Downloads (Pure)
    Open Access
    File
  • 17 Citations (Scopus)
    40 Downloads (Pure)
    Open Access
    File
  • 6 Citations (Scopus)
    286 Downloads (Pure)

    Editorial: roles of ion channels in immune cells

    Stokes, L., MacKenzie, A. B. & Sluyter, R., 15 Feb 2016, In : Frontiers in Immunology. 7, 48.

    Research output: Contribution to journalArticle

    Open Access
    File
    132 Downloads (Pure)

    Thesis

    Amyloid peptides and the vascular system : the link between cerebrovascular angiopathy and Alzheimer's disease

    Author: Alsheikh Abubaker, A., Dec 2019

    Supervisor: Eggleston, I. (Supervisor), Mackenzie, A. (Supervisor) & Pula, G. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Molecular mechanisms of YAP signalling in the context of cancer

    Author: Xie, B., 13 Feb 2019

    Supervisor: De Bank, P. (Supervisor), Mackenzie, A. (Supervisor), Ward, S. (Supervisor) & Mrsny, R. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File

    Targeted Fluorescent Probes for Diagnostic Applications

    Author: Weber, M., 15 Jan 2020

    Supervisor: James, T. (Supervisor), Bull, S. (Supervisor) & Mackenzie, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    The Development of Biological Therapeutics

    Author: Ali-Hassan, S., 31 Dec 2013

    Supervisor: Mackenzie, A. (Supervisor) & Watts, A. (Supervisor)

    Student thesis: Doctoral ThesisMPhil

    File

    The Functional Expression of N-Methyl-D-Aspartate Glutamate-Type Receptors by Megakaryocytes and Platelets

    Author: Hobbs, C., 1 May 2010

    Supervisor: Mackenzie, A. (Supervisor)

    Student thesis: Doctoral ThesisPhD

    File