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Alex Jeffries

Dr

  • MILNER CENTRE 1.12

20012010
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Research interests

I am interested in the evolution of bacterial genomes and use bioinformatics approaches to investigate this. Three aspects stand out; i) what are the functions of simple sequence repeats? ii) can we refine the detection of horizontal gene transfers through bioinformatics approaches? iii) can we find “missing” genes in bacterial genomes?


i) Simple sequence repeats (SSR) are short tandem repeats of nucleotide ‘words’ that are hypermutable, largely due to their ability to cause slip-strand mispairing by DNA polymerase. Their occurrence in bacterial genomes is usually attributed to their role in phase variation. Otherwise, they are considered deleterious and would be expected to be purged from genomes over time. We have discovered the significant widespread occurrence of SSRs in bacterial genomes in locations that are not consistent with phase variation. Discovering what are the role(s) of these SSR sequences is an ongoing challenge.


ii) Horizontal gene transfer (sometime called lateral gene transfer) is a significant force in the evolution of bacterial genomes. The availability of whole genome sequences has led to the development of a number of bioinformatics techniques for detecting regions that have been horizontally transferred. We are interested in developing more sensitive bioinformatics techniques for detection and also modelling the amelioration of horizontally transferred sequences in order to better understand their molecular evolution.


iii) The availability of whole genome sequences has allowed the identification of genes and prediction of metabolic pathways for specific organisms. Occasionally, metabolic pathways can be reconstructed but one gene appears be “missing” from the genome, but it is clear that this cannot be the case, otherwise the pathway would not function. We are investigating bioinformatics methods for systematically identifying such “missing” genes using non-primary structure based approaches.

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  • 19 Similar Profiles
Thermoplasma Medicine & Life Sciences
Multienzyme Complexes Medicine & Life Sciences
Keto Acids Medicine & Life Sciences
Bacterial Genomes Medicine & Life Sciences
Archaea Medicine & Life Sciences
Computational Biology Medicine & Life Sciences
Oxidoreductases Medicine & Life Sciences
Genome Medicine & Life Sciences

Research Output 2001 2010

59 Citations (Scopus)

The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formation

Sherwood, V., Recino, A., Jeffries, A., Ward, A. & Chalmers, A. D., 2010, In : Biochemical Journal. 425, 2, p. 303-311 9 p.

Research output: Contribution to journalReview article

File
Association reactions
Neoplasms
Proteins
Tumors
Protein Domains
17 Citations (Scopus)
Thermoplasma
Multienzyme Complexes
Keto Acids
Archaea
Oxidoreductases

Multienzyme complexes in the Archaea: predictions from genome sequences

Danson, M. J., Morgan, D. J., Jeffries, A. C., Hough, D. W. & Dyall-Smith, M. L., 2004, Halophilic Microorganisms. Ventosa, A. (ed.). Springer, p. 177-191 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Experimentally revised repertoire of putative contingency loci in Neisseria meningitidis strain MC58: evidence for a novel mechanism of phase variation

Martin, P., Ven, T. V., Mouchel, N., Jeffries, A. C., Hood, D. W. & Moxon, E. R., 2003, In : Molecular Microbiology. 50, p. 245--257 13 p.

Research output: Contribution to journalArticle

Genome analysis and strain comparison of correla repeats and correla repeat-enclosed elements in pathogenic Neisseria

Liu, S. V., Saunders, N. J., Jeffries, A. & Rest, R. F., 2002, In : Journal of Bacteriology. 184, p. 6163--6173 11 p.

Research output: Contribution to journalArticle