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19952019
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Research Output 1995 2019

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Article
2019

Inhibition of extracellular proteases improves the production of a xylanase in Parageobacillus thermoglucosidasius

Holland, A. T. N., Danson, M. J. & Bolhuis, A., 20 Mar 2019, In : BMC Biotechnology. 19, 1, 17.

Research output: Contribution to journalArticle

Open Access
6 Downloads (Pure)
Open Access
File
2018
2 Citations (Scopus)
22 Downloads (Pure)
Open Access
File
Amphotericin B
Bovine Serum Albumin
Critical Illness
Pharmaceutical Preparations
Health Services Needs and Demand
2017
9 Citations (Scopus)

Antibiofilm activity of α-mangostin extracted from Garcinia mangostana L. against Staphylococcus aureus

Nguyen, P. T. M., Quang, N. V., Mai, T. T., Kukukam, C., Reutrakul, V. & Bolhuis, A., Dec 2017, In : Asian Pacific Journal of Tropical Biomedicine. 10, 12, p. 1154-1160

Research output: Contribution to journalArticle

Open Access
Garcinia mangostana
Garcinia
Methicillin
Staphylococcus aureus
Biofilms
5 Citations (Scopus)
130 Downloads (Pure)

Anticaries and antimicrobial activities of methanolic extract from leaves of Cleistocalyx operculatus L.

Nguyen, P. T. M., Schultze, N., Boger, C., Alresley, Z., Bolhuis, A. & Lindequist, U., Jan 2017, In : Asian Pacific Journal of Tropical Biomedicine. 7, 1, p. 43-48

Research output: Contribution to journalArticle

Open Access
File
Syzygium
Bacteria
Streptococcus mutans
Biofilms
Flavonoids
2016
1 Citation (Scopus)
118 Downloads (Pure)

Development of a filter to prevent infections with spore-forming bacteria in injecting drug users

Alhusein, N., Scott, J., Kasprzyk-Hordern, B. & Bolhuis, A., 1 Dec 2016, In : Harm Reduction Journal. 13, 1, 8 p., 33.

Research output: Contribution to journalArticle

Open Access
File
Heroin
Drug Users
Spores
Bacterial Spores
Bacteria
24 Citations (Scopus)
Zein
Biofilms
Tetracycline
Staphylococcus aureus
Skin
2015
8 Citations (Scopus)
106 Downloads (Pure)

Application of fluid dynamic gauging in the characterization and removal of biofouling deposits

Peck, O. P. W., Chew, Y. M. J., Bird, M. R. & Bolhuis, A., 2015, In : Heat Transfer Engineering. 36, 7-8, p. 685-694 10 p.

Research output: Contribution to journalArticle

Open Access
File
Biofouling
biofilms
Gaging
Biofilms
fluid dynamics
24 Citations (Scopus)
113 Downloads (Pure)

Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens

Kortman, G. A. M., Mulder, M. L. M., Richters, T. J. W., Shanmugam, N. K. N., Trebicka, E., Boekhorst, J., Timmerman, H. M., Roelofs, R., Wiegerinck, E. T., Laarakkers, C. M., Swinkels, D. W., Bolhuis, A., Cherayil, B. J. & Tjalsma, H., Sep 2015, In : European Journal of Immunology. 45, 9, p. 2553-2567 13 p.

Research output: Contribution to journalArticle

File
Dietary Iron
Iron
Pathology
Food
Infection
2014
19 Citations (Scopus)
108 Downloads (Pure)

DNA as a target for antimicrobials

Bolhuis, A. & Aldrich-Wright, J. R., Aug 2014, In : Bioorganic Chemistry. 55, p. 51-59

Research output: Contribution to journalArticle

File
DNA
Infection
Anti-Bacterial Agents
Delivery of Health Care
39 Citations (Scopus)
61 Downloads (Pure)

The antimicrobial and antibiofilm activities of copper(II) complexes

Beeton, M., Aldrich-Wright, J. R. & Bolhuis, A., 1 Nov 2014, In : Journal of Inorganic Biochemistry. 140, p. 167-172 6 p.

Research output: Contribution to journalArticle

File
Biofilms
Copper
Methicillin
Staphylococcus aureus
Copper compounds
2013
20 Citations (Scopus)
121 Downloads (Pure)
Open Access
File
Nanofibers
Biofilms
Tetracycline
Bacteria
Anti-Bacterial Agents
2012
15 Citations (Scopus)

Copper(ii) and palladium(ii) complexes with cytotoxic and antibacterial activity

Krause-Heuer, A. M., Leverett, P., Aldrich-Wright, J. R. & Bolhuis, A., 1 Jan 2012, In : Australian Journal of Chemistry. 65, 7, p. 860-873 14 p.

Research output: Contribution to journalArticle

Palladium
Copper
Cells
Cytotoxicity
Methylation
3 Citations (Scopus)
104 Downloads (Pure)

Mutations in the translation initiation region of the pac gene resulting in increased levels of activity of penicillin G acylase

Akkaya, Ö., İşsever Öztürk, S., Bolhuis, A. & Gümüşel, F., 2012, In : World Journal of Microbiology and Biotechnology. 28, 5, p. 2159-2164 6 p.

Research output: Contribution to journalArticle

Open Access
File
Penicillin Amidase
Mutation
Initiator Codon
Genes
Escherichia coli
135 Citations (Scopus)
107 Downloads (Pure)

Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity

Howson, S. E., Bolhuis, A., Brabec, V., Clarkson, G. J., Malina, J., Rodger, A. & Scott, P., Jan 2012, In : Nature Chemistry. 4, 1, p. 31-36 6 p.

Research output: Contribution to journalArticle

Open Access
File
Antibiotics
Bacteria
Anti-Bacterial Agents
Methicillin
Enantiomers
2011
77 Citations (Scopus)
115 Downloads (Pure)

Antimicrobial activity of ruthenium-based intercalators

Bolhuis, A., Hand, L., Marshall, J. E., Richards, A. D., Rodger, A. & Aldrich-Wright, J., 18 Mar 2011, In : European Journal of Pharmaceutical Sciences. 42, 4, p. 313-317 5 p.

Research output: Contribution to journalArticle

Open Access
File
Intercalating Agents
Nematode Infections
Escherichia
Ruthenium
Poisons
5 Citations (Scopus)

Functional analysis of the sortase YhcS in Bacillus subtilis

Fasehee, H., Westers, H., Bolhuis, A., Antelmann, H., Hecker, M., Quax, W. J., Mirlohi, A. F., van Dijl, J. M. & Ahmadian, G., 2011, In : Proteomics. 11, 19, p. 3905-3913 9 p.

Research output: Contribution to journalArticle

Functional analysis
Bacilli
Bacillus subtilis
Cell Wall
Cells
97 Citations (Scopus)

Novel clues on the specific association of Streptococcus gallolyticus subsp gallolyticus with colorectal cancer

Boleij, A., Muytjens, C. M. J., Bukhari, S. I., Cayet, N., Glaser, P., Hermans, P. W. M., Swinkels, D. W., Bolhuis, A. & Tjalsma, H., 15 Apr 2011, In : Journal of Infectious Diseases. 203, 8, p. 1101-1109 9 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Biofilms
Bacteria
Collagen
Epithelium
2010
5 Citations (Scopus)

Analysis of the twin-arginine motif of a haloarchaeal Tat substrate

Kwan, D. & Bolhuis, A., Jul 2010, In : FEMS Microbiology Letters. 308, 2, p. 138-143 6 p.

Research output: Contribution to journalArticle

Arginine
Archaea
Consensus Sequence
Protein Sorting Signals
Computational Biology
2009
50 Citations (Scopus)

Antimicrobial activity of an iron triple helicate

Richards, A. D., Rodger, A., Hannon, M. J. & Bolhuis, A., May 2009, In : International Journal of Antimicrobial Agents. 33, 5, p. 469-472 4 p.

Research output: Contribution to journalArticle

Bacillus subtilis
Iron
Bacterial DNA
DNA
Microbial Drug Resistance

Enterococcal surface protein Esp affects antibiotic sensitivity in Enterococcus faecium

Meredith, K., Bolhuis, A. & O’Neill, M. A. A., 2009, In : International Journal of Antimicrobial Agents. 34, 4, p. 392-393 2 p.

Research output: Contribution to journalArticle

2008
8 Citations (Scopus)

Bioenergetic requirements of a Tat-dependent substrate in the halophilic archaeon Haloarcula hispanica

Kwan, D. C., Thomas, J. R. & Bolhuis, A., Dec 2008, In : FEBS Journal. 275, 24, p. 6159-6167 9 p.

Research output: Contribution to journalArticle

Haloarcula
Archaea
energy metabolism
arginine
proteins
2006
21 Citations (Scopus)

The tatC gene cluster is essential for viability in halophilic archaea

Thomas, J. R. & Bolhuis, A., 2006, In : FEMS Microbiology Letters. 256, 1, p. 44-49 6 p.

Research output: Contribution to journalArticle

2005
75 Citations (Scopus)

Characterisation of a highly stable α-amylase from the halophilic archaeon Haloarcula hispanica

Hutcheon, G. W., Vasisht, N. & Bolhuis, A., 2005, In : Extremophiles. 9, p. 487-495 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The core TatABC complex of the twin-arginine translocase in Escherichia coli : TatC drives assembly whereas TatA is essential for stability

Mangels, D., Mathers, J., Bolhuis, A. & Robinson, C., 2005, In : Journal of Molecular Biology. 345, p. 415-423 9 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

The twin-arginine translocation apparatus incorporates a distinct form of TatABC complex, spectrum of modular TatA complexes and minor TatAB complex

Oates, J., Barrett, C., Barnett, J., Byrne, K., Bolhuis, A. & Robinson, C., 2005, In : Journal of Molecular Biology. 346, 1, p. 295-305 11 p.

Research output: Contribution to journalArticle

Arginine
Gels
Thylakoids
Electrophoresis
Carrier Proteins
2004

Early transport: Protein secretion pathways in Archaea

Bolhuis, A., 2004, In : The Biochemist. 26, 3, p. 16-18 3 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Tat-dependent protein targeting in prokaryotes and chloroplasts

Robinson, C. & Bolhuis, A., 2004, In : Biochimica et Biophysica Acta. 1694, p. 135-147 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2003
62 Citations (Scopus)

Quantitative export of a reporter protein, GFP, by the twin-arginine translocation pathway in Escherichia coli

Barrett, C. M. L., Ray, N., Thomas, J. D., Robinson, C. & Bolhuis, A., 2003, In : Biochemical and Biophysical Research Communications. 304, 2, p. 279-284 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The archael twin-arginine translocation pathway

Hutcheon, G. W. & Bolhuis, A., 2003, In : Biochemical Society Transactions. 31, 3, p. 686-689 4 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

YidC is strictly required for membrane insertion of subunits a and c of the F 1 F 0 ATP synthase and SecE of the SecYEG translocase

Yi, L., Jiang, F., Chen, M., Cain, B., Bolhuis, A. & Dalbey, R., 2003, In : Biochemistry. 42, p. 10537-10544 8 p.

Research output: Contribution to journalArticle

2002
66 Citations (Scopus)
67 Citations (Scopus)

The bdbDC operon of bacillus subtilis encodes thiol-disulfide oxidoreductases required for competence development

Meima, R., Eschevins, C., Fillinger, S., Bolhuis, A., Hamoen, L. W., Dorenbos, R., Quax, W. J., van Dijl, J. M., Provvedi, R., Chen, I., Dubnau, D. & Bron, S., 2002, In : Journal of Biological Chemistry. 277, 9, p. 6994-7001 8 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Thiol-disulfide oxidoreductases are essential for the production of the lantibiotic sublancin 168

Dorenbos, R., Stein, T., Kabel, J., Bruand, C., Bolhuis, A., Bron, S., Quax, W. J. & van Dijl, J. M., 2002, In : Journal of Biological Chemistry. 277, 19, p. 16682-16888 207 p.

Research output: Contribution to journalArticle

2001
114 Citations (Scopus)

A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress

Hyyryläinen, H. L., Bolhuis, A., Darmon, E., Muukkonen, L., Koski, P., Vitikainen, M., Sarvas, M., Prágai, Z., Bron, S., van Dijl, J. M. & Kontinen, V. P., 2001, In : Molecular Microbiology. 41, 5, p. 1159-1172 14 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Protein targeting by the twin-arginine translocation pathway

Robinson, C. & Bolhuis, A., 2001, In : Nature Reviews Molecular Cell Biology. 2, p. 350-356 7 p.

Research output: Contribution to journalArticle

206 Citations (Scopus)

TatB and TatC form a functional and structural unit of the twin arginine translocase from Escherichia coli.

Bolhuis, A., Mathers, J. E., Thomas, J. D., Barrett, C. L. & Robinson, C., 2001, In : Journal of Biological Chemistry. 276, 23, p. 20213-20219 7 p.

Research output: Contribution to journalArticle

2000
12 Citations (Scopus)

Did the mitochondrial processing peptidase evolve from a eubacterial regulator of gene expression?

Bolhuis, A., Koetje, E., Dubois, J. Y., Vehmaanpera, J., Venema, G., Bron, S. & van Dijl, J. M., 2000, In : Molecular Biology and Evolution. 17, 1, p. 198-201 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Novel mechanisms for the targeting of proteins into and across chloroplast membranes

Woolhead, C., Bolhuis, A. & Robinson, C., 2000, In : Biochemical Society Transactions. 28, p. 491-494 4 p.

Research output: Contribution to journalArticle

Protein Transport
Chloroplasts
Thylakoid Membrane Proteins
Chloroplast Proteins
Membranes
567 Citations (Scopus)

Signal peptide-dependent protein transport in Bacillus subtilis: a genome-based survey of the secretome

Tjalsma, H., Bolhuis, A., Jongbloed, J. D. H., Bron, S. & van Dijl, J. M., 2000, In : Microbiology and Molecular Biology Reviews. 64, 3, p. 515-547 33 p.

Research output: Contribution to journalArticle

Protein Transport
Protein Sorting Signals
Bacillus subtilis
Genome
Proteins
61 Citations (Scopus)

Subunit interactions in the twin-arginine translocase complex of Escherichia coli

Bolhuis, A., Bogsch, E. G. & Robinson, C., 2000, In : FEBS Letters. 472, 1, p. 88-92 5 p.

Research output: Contribution to journalArticle

Escherichia coli
Arginine
Genes
Periplasm
Escherichia coli Proteins
1999
36 Citations (Scopus)

Different mechanisms for thermal inactivation of Bacillus subtilis signal peptidase mutants

Bolhuis, A., Tjalsma, H., Stephenson, K., Harwood, C. R., Venema, G., Bron, S. & Van Dijl, J. M., 28 May 1999, In : Journal of Biological Chemistry. 274, 22, p. 15865-15868 4 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Evaluation of bottlenecks in the late stages of protein secretion in Bacillus subtilis

Bolhuis, A., Tjalsma, H., Smith, H. E., De Jong, A., Meima, R., Venema, G., Bron, S. & Van Dijl, J. M., 1 Jul 1999, In : Applied and Environmental Microbiology. 65, 7, p. 2934-2941 8 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Functional analysis of paralogous thiol-disulfide oxidoreductases in Bacillus subtilis

Bolhuis, A., Venema, G., Quax, W. J., Bron, S. & Van Dijl, J. M., 27 Aug 1999, In : Journal of Biological Chemistry. 274, 35, p. 24531-24538 8 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Signal peptide peptidase- and ClpP-like proteins of Bacillus subtilis required for efficient translocation and processing of secretory proteins

Bolhuis, A., Matzen, A., Hyyryläinen, H. L., Kontinen, V. P., Meima, R., Chapuis, J., Venema, G., Bron, S., Freudl, R. & Van Dijl, J. M., 27 Aug 1999, In : Journal of Biological Chemistry. 274, 35, p. 24585-24592 8 p.

Research output: Contribution to journalArticle

1998
24 Citations (Scopus)

Cloning, expression, and chromosomal stabilization of the Propionibacterium shermanii proline iminopeptidase gene (pip) for food-grade application in Lactococcus lactis

Leenhouts, K., Bolhuis, A., Boot, J., Deutz, I., Toonen, M., Venema, G., Kok, J. & Ledeboer, A., 1 Dec 1998, In : Applied and Environmental Microbiology. 64, 12, p. 4736-4742 7 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Construction of a food-grade multiple-copy integration system for Lactococcus lactis

Leenhouts, K., Bolhuis, A., Venema, G. & Kok, J., 14 May 1998, In : Applied Microbiology and Biotechnology. 49, 4, p. 417-423 7 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)

Functional analysis of the secretory precursor processing machinery of Bacillus subtilis: Identification of a eubacterial homolog of archaeal and eukaryotic signal peptidases

Tjalsma, H., Bolhuis, A., Van Roosmalen, M. L., Wiegert, T., Schumann, W., Broekhuizen, C. P., Quax, W. J., Venema, G., Bron, S. & Van Dijl, J. M., 1 Aug 1998, In : Genes and Development. 12, 15, p. 2318-2331 14 p.

Research output: Contribution to journalArticle

Open Access