Adele Murrell

Deputy Head of Department Biology and Biochemistry, Prof

  • 4 SOUTH 0.56

Accepting PhD Students

20042022
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Research Output 2004 2019

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Article
2016
14 Citations (Scopus)

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Ross-Adams, H., Ball, S., Lawrenson, K., Halim, S., Russell, R., Wells, C., Strand, S. H., Ørntoft, T. F., Larson, M., Armasu, S., Massie, C. E., Asim, M., Mortensen, M. M., Borre, M., Woodfine, K., Warren, A. Y., Lamb, A. D., Kay, J., Whitaker, H., Ramos-Montoya, A. & 8 othersMurrell, A., Sørensen, K. D., Fridley, B. L., Goode, E. L., Gayther, S. A., Masters, J., Neal, D. E. & Mills, I. G., 9 Oct 2016, In : Oncotarget. 7, 46, p. 74734-74746 13 p.

Research output: Contribution to journalArticle

Open Access
Gene Regulatory Networks
Ovarian Neoplasms
Methylation
Prostatic Neoplasms
Epithelial-Mesenchymal Transition
19 Citations (Scopus)

Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions: 2 

Stojic, L., Niemczyk, M., Orjalo, A., Ito, Y., Ruijter, A. E. M., Uribe-Lewis, S., Joseph, N., Weston, S., Menon, S., Odom, D. T., Rinn, J., Gergely, F. & Murrell, A., 2 Feb 2016, In : Nature Communications. 7, 10406.

Research output: Contribution to journalArticle

Open Access
File
Long Noncoding RNA
Small Interfering RNA
interference
suppressors
dissection
2015
101 Citations (Scopus)

5-Formylcytosine can be a stable DNA modification in mammals

Bachman, M., Uribe-Lewis, S., Yang, X., Burgess, H. E., Iurlaro, M., Reik, W., Murrell, A. & Balasubramanian, S., Aug 2015, In : Nature Chemical Biology. 11, 8, p. 555-557 3 p.

Research output: Contribution to journalArticle

File
Mammals
DNA
Isotope Labeling
5-formylcytosine
32 Citations (Scopus)

5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer

Uribe-lewis, S., Stark, R., Carroll, T., Dunning, M. J., Bachman, M., Ito, Y., Stojic, L., Halim, S., Vowler, S. L., Lynch, A. G., Delatte, B., De Bony, E. J., Colin, L., Defrance, M., Krueger, F., Silva, A., Ten Hoopen, R., Ibrahim, A. E., Fuks, F. & Murrell, A., 1 Apr 2015, In : Genome Biology. 16, 1, 69.

Research output: Contribution to journalArticle

Open Access
colon
methylation
cancer
Colon
colorectal neoplasms
2014
177 Citations (Scopus)

5-Hydroxymethylcytosine is a predominantly stable DNA modification

Bachman, M., Uribe-Lewis, S., Yang, X., Williams, M., Murrell, A. & Balasubramanian, S., Dec 2014, In : Nature Chemistry. 6, p. 1049-1055 7 p.

Research output: Contribution to journalArticle

DNA
Labeling
Cells
5-Methylcytosine
Oxidation
2 Citations (Scopus)

Cross-talk between imprinted loci in Prader-Willi syndrome

Murrell, A., Jun 2014, In : Nature Genetics. 46, 6, p. 528-530 3 p.

Research output: Contribution to journalArticle

Prader-Willi Syndrome
Long Noncoding RNA
Chromosomes, Human, Pair 15
Gene Regulatory Networks
Genes
2013
18 Citations (Scopus)

A novel mechanism for CTCF in the epigenetic regulation of Bax in breast cancer cells

Méndez-Catalá, C. F., Gretton, S., Vostrov, A., Pugacheva, E., Farrar, D., Ito, Y., Docquier, F., Kita, G-X., Murrell, A., Lobanenkov, V. & Klenova, E., Aug 2013, In : Neoplasia : An International Journal for Oncology Research. 15, 8, p. 898-912 15 p.

Research output: Contribution to journalArticle

Epigenomics
Breast Neoplasms
Binding Sites
bcl-2-Associated X Protein
Breast
78 Citations (Scopus)

Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins

Wu, L., Murat, P., Matak-Vinkovic, D., Murrell, A. & Balasubramanian, S., 31 Dec 2013, In : Biochemistry. 52, 52

Research output: Contribution to journalArticle

Long Noncoding RNA
Polycomb-Group Proteins
Epigenomics
Proteins
Molecular interactions
11 Citations (Scopus)

Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA

Niemczyk, M., Ito, Y., Huddleston, J., Git, A., Abu-Amero, S., Caldas, C., Moore, GE., Stojic, L. & Murrell, A., 8 Aug 2013, In : American Journal of Human Genetics. 93, 2, p. 224-235

Research output: Contribution to journalArticle

Long Noncoding RNA
Alternative Splicing
Chromatin
Alleles
Breast Neoplasms
20 Citations (Scopus)

Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus

Ito, Y., Nativio, R. & Murrell, A., 1 May 2013, In : Nucleic Acids Research. 41, 10, p. 5290-302 13 p.

Research output: Contribution to journalArticle

Somatomedins
Chromatin
DNA
Epigenomics
Choriocarcinoma
2012
80 Citations (Scopus)

Diverse epigenetic strategies interact to control epidermal differentiation

Mulder, K. W., Wang, X., Escriu, C., Ito, Y., Schwarz, R. F., Gillis, J., Sirokmány, G., Donati, G., Uribe-Lewis, S., Pavlidis, P., Murrell, A., Markowetz, F. & Watt, F. M., Jul 2012, In : Nature cell biology. 14, 7, p. 753-63 11 p.

Research output: Contribution to journalArticle

Epigenomics
Stem Cells
Gene Regulatory Networks
Gene Expression Regulation
Integrins
1 Citation (Scopus)

Quantitative chromosome conformation capture

Nativio, R., Ito, Y. & Murrell, A., 2012, In : Methods in Molecular Biology. 925, p. 173-185 13 p.

Research output: Contribution to journalArticle

Chromatin
Chromosomes
28 Citations (Scopus)

Status of genomic imprinting in epigenetically distinct pluripotent stem cells

Sun, B., Ito, M., Mendjan, S., Ito, Y., Brons, I. G. M., Murrell, A., Vallier, L., Ferguson-Smith, A. C. & Pedersen, R. A., Feb 2012, In : Stem Cells . 30, 2, p. 161-168 8 p.

Research output: Contribution to journalArticle

Genomic Imprinting
Germ Layers
Pluripotent Stem Cells
Stem Cells
Embryonic Stem Cells
2011
55 Citations (Scopus)

Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome

Nativio, R., Sparago, A., Ito, Y., Weksberg, R., Riccio, A. & Murrell, A., 1 Apr 2011, In : Human Molecular Genetics. 20, 7, p. 1363-1374 12 p.

Research output: Contribution to journalArticle

Open Access
File
Silver-Russell Syndrome
Beckwith-Wiedemann Syndrome
Insulin-Like Growth Factor II
Chromatin
DNA Methylation
212 Citations (Scopus)

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets

Sandovici, I., Smith, N. H., Nitert, M. D., Ackers-Johnson, M., Uribe-Lewis, S., Ito, Y., Jones, R. H., Marquez, V. E., Cairns, W., Tadayyon, M., O'Neill, L. P., Murrell, A., Ling, C., Constância, M. & Ozanne, S. E., 29 Mar 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 13, p. 5449-54 6 p.

Research output: Contribution to journalArticle

Islets of Langerhans
Epigenomics
Mothers
Diet
Genes
49 Citations (Scopus)

Molecular mechanisms of genomic imprinting and clinical implications for cancer

Uribe-Lewis, S., Woodfine, K., Stojic, L. & Murrell, A., 2011, In : Expert Reviews in Molecular Medicine. 13, e2.

Research output: Contribution to journalArticle

Genomic Imprinting
Epigenomics
Neoplasms
Genes
Gene Expression
68 Citations (Scopus)
Open Access
File
DNA Methylation
Epigenomics
Germ Cells
Genes
Genomic Imprinting
10 Citations (Scopus)

Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing

Huntriss, J., Woodfine, K., Huddleston, J. E., Murrell, A., Rutherford, A. J., Elder, K., Khan, A. A., Hemmings, K. & Picton, H., 30 Jun 2011, In : Fertility and Sterility. 95, 8, p. 2564-2567.e8

Research output: Contribution to journalArticle

snRNP Core Proteins
Blastocyst
DNA Methylation
Genes
Cell Line
69 Citations (Scopus)

Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression

Ibrahim, A. E. K., Arends, M. J., Silva, A-L., Wyllie, A. H., Greger, L., Ito, Y., Vowler, S. L., Huang, T. H-M., Tavaré, S., Murrell, A. & Brenton, J. D., Apr 2011, In : Gut. 60, 4, p. 499-508 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Methylation
CpG Islands
Adenoma
Phenotype
14 Citations (Scopus)

Setting up and maintaining differential insulators and boundaries for genomic imprinting

Murrell, A., Oct 2011, In : Biochemistry and Cell Biology . 89, 5, p. 469-478 10 p.

Research output: Contribution to journalArticle

Genomic Imprinting
Insulator Elements
Chromatin
Genes
Regulator Genes
2010
1 Citation (Scopus)

Beyond genomic imprinting

Murrell, A., Jul 2010, In : Briefings in Functional Genomics. 9, 4, p. 279-280

Research output: Contribution to journalArticle

23 Citations (Scopus)

Evaluation of allelic expression of imprinted genes in adult human blood

Frost, J. M., Monk, D., Stojilkovic-Mikic, T., Woodfine, K., Chitty, L. S., Murrell, A., Stanier, P. & Moore, G. E., 2010, In : PLoS ONE. 5, 10, e13556.

Research output: Contribution to journalArticle

Open Access
File
Blood
Genes
Gene Expression
gene expression
blood
48 Citations (Scopus)

Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation

Farrar, D., Rai, S., Chernukhin, I., Jagodic, M., Ito, Y., Yammine, S., Ohlsson, R., Murrell, A. & Klenova, E., Mar 2010, In : Molecular and Cellular Biology. 30, 5, p. 1199-1216 18 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate
Transcription Factors
Chromatin Immunoprecipitation
Computational Biology
Transcriptional Activation
2009
235 Citations (Scopus)

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus

Nativio, R., Wendt, K. S., Ito, Y., Huddleston, J. E., Uribe-lewis, S., Woodfine, K., Krueger, C., Reik, W., Peters, J-M. & Murrell, A., 26 Nov 2009, In : Plos Genetics. 5, 11, p. e1000739

Research output: Contribution to journalArticle

67 Citations (Scopus)

Generation of an epigenetic signature by chronic hypoxia in prostate cells

Watson, J. A., Watson, C. J., McCrohan, A-M., Woodfine, K., Tosetto, M., McDaid, J., Gallagher, E., Betts, D., Baugh, J., O'Sullivan, J., Murrell, A., Watson, R. W. G. & McCann, A., 1 Oct 2009, In : Human Molecular Genetics. 18, 19, p. 3594-3604 11 p.

Research output: Contribution to journalArticle

Epigenomics
Prostate
DNA Methylation
Acetylation
Histones
2008
77 Citations (Scopus)

Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer

Murrell, A., Ito, Y., Verde, G., Huddleston, J., Woodfine, K., Silengo, M. C., Spreafico, F., Perotti, D., De Crescenzo, A., Sparago, A., Cerrato, F. & Riccio, A., 2008, In : PLoS ONE. 3, 3, e1849.

Research output: Contribution to journalArticle

growth disorders
Growth Disorders
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Methylation
methylation

Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis

Tomazou, E. M., Rakyan, V. K., Lefebvre, G., Andrews, R., Ellis, P., Jackson, D. K., Langford, C., Francis, M. D., Bäckdahl, L., Miretti, M., Coggill, P., Ottaviani, D., Sheer, D., Murrell, A. & Beck, S., 2008, In : BMC Medical Genomics. 1, 19.

Research output: Contribution to journalArticle

DNA Methylation
Major Histocompatibility Complex
Epigenomics
Immunity
Genome
99 Citations (Scopus)

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

Ito, Y., Koessler, T., Ibrahim, A. E. K., Rai, S., Vowler, S. L., Abu-Amero, S., Silva, A-L., Maia, A-T., Huddleston, J. E., Uribe-Lewis, S., Woodfine, K., Jagodic, M., Nativio, R., Dunning, A., Moore, G., Klenova, E., Bingham, S., Pharoah, P. D. P., Brenton, J. D., Beck, S. & 2 othersSandhu, M. S. & Murrell, A., 1 Sep 2008, In : Human Molecular Genetics. 17, 17, p. 2633-2643 11 p.

Research output: Contribution to journalArticle

Somatomedins
Colorectal Neoplasms
Breast Neoplasms
Neoplasms
Methylation
2004
115 Citations (Scopus)

An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype

Murrell, A., Heeson, S., Cooper, W. N., Douglas, E., Apostolidou, S., Moore, G. E., Maher, E. R. & Reik, W., 15 Jan 2004, In : Human Molecular Genetics. 13, 2, p. 247-255 9 p.

Research output: Contribution to journalArticle

Beckwith-Wiedemann Syndrome
Genotype
Haplotypes
Genes
Single Nucleotide Polymorphism
393 Citations (Scopus)

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops

Murrell, A., Heeson, S. & Reik, W., Aug 2004, In : Nature Genetics. 36, 8, p. 889-93 5 p.

Research output: Contribution to journalArticle

Somatomedins
Chromatin
Genes
Histone Code
Chromosomes, Human, Pair 7