Adele Murrell

Deputy Head of Department Biology and Biochemistry, Prof

  • 4 SOUTH 0.56

Accepting PhD Students

20042023

Research output per year

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Research Output

2020

5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation

Uribe-Lewis, S., Carroll, T., Menon, S., Nicholson, A., Manasterski, P. J., Winton, D. J., Buczacki, S. J. A. & Murrell, A., 17 Jan 2020, In : Scientific Reports. 10, 1, 546.

Research output: Contribution to journalArticle

Open Access
2019

Being in a loop: how long non-coding RNAs organise genome architecture

Pisignano, G., Pavlaki, I. & Murrell, A., 9 Apr 2019, In : Essays in Biochemistry. 63, 1, p. 177-186 10 p.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
6 Downloads (Pure)
2016

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Ross-Adams, H., Ball, S., Lawrenson, K., Halim, S., Russell, R., Wells, C., Strand, S. H., Ørntoft, T. F., Larson, M., Armasu, S., Massie, C. E., Asim, M., Mortensen, M. M., Borre, M., Woodfine, K., Warren, A. Y., Lamb, A. D., Kay, J., Whitaker, H., Ramos-Montoya, A. & 8 others, Murrell, A., Sørensen, K. D., Fridley, B. L., Goode, E. L., Gayther, S. A., Masters, J., Neal, D. E. & Mills, I. G., 9 Oct 2016, In : Oncotarget. 7, 46, p. 74734-74746 13 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions: 2 

Stojic, L., Niemczyk, M., Orjalo, A., Ito, Y., Ruijter, A. E. M., Uribe-Lewis, S., Joseph, N., Weston, S., Menon, S., Odom, D. T., Rinn, J., Gergely, F. & Murrell, A., 2 Feb 2016, In : Nature Communications. 7, 10406.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)
104 Downloads (Pure)
2015

5-Formylcytosine can be a stable DNA modification in mammals

Bachman, M., Uribe-Lewis, S., Yang, X., Burgess, H. E., Iurlaro, M., Reik, W., Murrell, A. & Balasubramanian, S., 13 Aug 2015, In : Nature Chemical Biology. 11, 8, p. 555-557 3 p.

Research output: Contribution to journalArticle

Open Access
File
129 Citations (Scopus)
81 Downloads (Pure)

5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer

Uribe-lewis, S., Stark, R., Carroll, T., Dunning, M. J., Bachman, M., Ito, Y., Stojic, L., Halim, S., Vowler, S. L., Lynch, A. G., Delatte, B., De Bony, E. J., Colin, L., Defrance, M., Krueger, F., Silva, A., Ten Hoopen, R., Ibrahim, A. E., Fuks, F. & Murrell, A., 1 Apr 2015, In : Genome Biology. 16, 1, p. 1-15 15 p., 69.

Research output: Contribution to journalArticle

Open Access
38 Citations (Scopus)

Analysis of DNA methylation patterns in single blastocysts by Pyrosequencing(®).

Huntriss, J., Woodfine, K., Huddleston, J. E., Murrell, A. & Picton, H. M., 2015, Pyrosequencing: Methods and Protocols - Part III. Lehmann, U. & Tost, J. (eds.). New York, U. S. A.: Springer, p. 259-270 (Methods in Molecular Biology; vol. 1315).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Epigenetics and disease

Murrell, A., Nov 2015, Epigenetics for Drug Discovery. Carey, N. (ed.). Abingdon, U. K.: Royal Society of Chemistry, p. 47-67 21 p. (RSC Drug Discovery Series; vol. January 2016, no. 48).

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

5-Hydroxymethylcytosine is a predominantly stable DNA modification

Bachman, M., Uribe-Lewis, S., Yang, X., Williams, M., Murrell, A. & Balasubramanian, S., 1 Dec 2014, In : Nature Chemistry. 6, 12, p. 1049-1055 7 p.

Research output: Contribution to journalArticle

230 Citations (Scopus)

Cross-talk between imprinted loci in Prader-Willi syndrome

Murrell, A., Jun 2014, In : Nature Genetics. 46, 6, p. 528-530 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2013

A novel mechanism for CTCF in the epigenetic regulation of Bax in breast cancer cells

Méndez-Catalá, C. F., Gretton, S., Vostrov, A., Pugacheva, E., Farrar, D., Ito, Y., Docquier, F., Kita, G-X., Murrell, A., Lobanenkov, V. & Klenova, E., Aug 2013, In : Neoplasia : An International Journal for Oncology Research. 15, 8, p. 898-912 15 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins

Wu, L., Murat, P., Matak-Vinkovic, D., Murrell, A. & Balasubramanian, S., 31 Dec 2013, In : Biochemistry. 52, 52

Research output: Contribution to journalArticle

93 Citations (Scopus)

Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA

Niemczyk, M., Ito, Y., Huddleston, J., Git, A., Abu-Amero, S., Caldas, C., Moore, GE., Stojic, L. & Murrell, A., 8 Aug 2013, In : American Journal of Human Genetics. 93, 2, p. 224-235

Research output: Contribution to journalArticle

13 Citations (Scopus)

Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus

Ito, Y., Nativio, R. & Murrell, A., 1 May 2013, In : Nucleic Acids Research. 41, 10, p. 5290-302 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2012

Diverse epigenetic strategies interact to control epidermal differentiation

Mulder, K. W., Wang, X., Escriu, C., Ito, Y., Schwarz, R. F., Gillis, J., Sirokmány, G., Donati, G., Uribe-Lewis, S., Pavlidis, P., Murrell, A., Markowetz, F. & Watt, F. M., Jul 2012, In : Nature cell biology. 14, 7, p. 753-63 11 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Quantitative chromosome conformation capture

Nativio, R., Ito, Y. & Murrell, A., 2012, In : Methods in Molecular Biology. 925, p. 173-185 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Status of genomic imprinting in epigenetically distinct pluripotent stem cells

Sun, B., Ito, M., Mendjan, S., Ito, Y., Brons, I. G. M., Murrell, A., Vallier, L., Ferguson-Smith, A. C. & Pedersen, R. A., Feb 2012, In : Stem Cells . 30, 2, p. 161-168 8 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2011

Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome

Nativio, R., Sparago, A., Ito, Y., Weksberg, R., Riccio, A. & Murrell, A., 1 Apr 2011, In : Human Molecular Genetics. 20, 7, p. 1363-1374 12 p.

Research output: Contribution to journalArticle

Open Access
File
57 Citations (Scopus)
108 Downloads (Pure)

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets

Sandovici, I., Smith, N. H., Nitert, M. D., Ackers-Johnson, M., Uribe-Lewis, S., Ito, Y., Jones, R. H., Marquez, V. E., Cairns, W., Tadayyon, M., O'Neill, L. P., Murrell, A., Ling, C., Constância, M. & Ozanne, S. E., 29 Mar 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 13, p. 5449-54 6 p.

Research output: Contribution to journalArticle

229 Citations (Scopus)

Molecular mechanisms of genomic imprinting and clinical implications for cancer

Uribe-Lewis, S., Woodfine, K., Stojic, L. & Murrell, A., 2011, In : Expert Reviews in Molecular Medicine. 13, e2.

Research output: Contribution to journalArticle

57 Citations (Scopus)
Open Access
File
72 Citations (Scopus)
116 Downloads (Pure)

Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing

Huntriss, J., Woodfine, K., Huddleston, J. E., Murrell, A., Rutherford, A. J., Elder, K., Khan, A. A., Hemmings, K. & Picton, H., 30 Jun 2011, In : Fertility and Sterility. 95, 8, p. 2564-2567.e8

Research output: Contribution to journalArticle

10 Citations (Scopus)

Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression

Ibrahim, A. E. K., Arends, M. J., Silva, A-L., Wyllie, A. H., Greger, L., Ito, Y., Vowler, S. L., Huang, T. H-M., Tavaré, S., Murrell, A. & Brenton, J. D., Apr 2011, In : Gut. 60, 4, p. 499-508 10 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Setting up and maintaining differential insulators and boundaries for genomic imprinting

Murrell, A., Oct 2011, In : Biochemistry and Cell Biology . 89, 5, p. 469-478 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2010

Beyond genomic imprinting

Murrell, A., Jul 2010, In : Briefings in Functional Genomics. 9, 4, p. 279-280

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluation of allelic expression of imprinted genes in adult human blood

Frost, J. M., Monk, D., Stojilkovic-Mikic, T., Woodfine, K., Chitty, L. S., Murrell, A., Stanier, P. & Moore, G. E., 2010, In : PLoS ONE. 5, 10, e13556.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
120 Downloads (Pure)

Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation

Farrar, D., Rai, S., Chernukhin, I., Jagodic, M., Ito, Y., Yammine, S., Ohlsson, R., Murrell, A. & Klenova, E., Mar 2010, In : Molecular and Cellular Biology. 30, 5, p. 1199-1216 18 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2009

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus

Nativio, R., Wendt, K. S., Ito, Y., Huddleston, J. E., Uribe-lewis, S., Woodfine, K., Krueger, C., Reik, W., Peters, J-M. & Murrell, A., 26 Nov 2009, In : Plos Genetics. 5, 11, p. e1000739

Research output: Contribution to journalArticle

238 Citations (Scopus)

Generation of an epigenetic signature by chronic hypoxia in prostate cells

Watson, J. A., Watson, C. J., McCrohan, A-M., Woodfine, K., Tosetto, M., McDaid, J., Gallagher, E., Betts, D., Baugh, J., O'Sullivan, J., Murrell, A., Watson, R. W. G. & McCann, A., 1 Oct 2009, In : Human Molecular Genetics. 18, 19, p. 3594-3604 11 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2008

Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer

Murrell, A., Ito, Y., Verde, G., Huddleston, J., Woodfine, K., Silengo, M. C., Spreafico, F., Perotti, D., De Crescenzo, A., Sparago, A., Cerrato, F. & Riccio, A., 2008, In : PLoS ONE. 3, 3, e1849.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis

Tomazou, E. M., Rakyan, V. K., Lefebvre, G., Andrews, R., Ellis, P., Jackson, D. K., Langford, C., Francis, M. D., Bäckdahl, L., Miretti, M., Coggill, P., Ottaviani, D., Sheer, D., Murrell, A. & Beck, S., 2008, In : BMC Medical Genomics. 1, 19.

Research output: Contribution to journalArticle

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

Ito, Y., Koessler, T., Ibrahim, A. E. K., Rai, S., Vowler, S. L., Abu-Amero, S., Silva, A-L., Maia, A-T., Huddleston, J. E., Uribe-Lewis, S., Woodfine, K., Jagodic, M., Nativio, R., Dunning, A., Moore, G., Klenova, E., Bingham, S., Pharoah, P. D. P., Brenton, J. D., Beck, S. & 2 others, Sandhu, M. S. & Murrell, A., 1 Sep 2008, In : Human Molecular Genetics. 17, 17, p. 2633-2643 11 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)
2004

An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype

Murrell, A., Heeson, S., Cooper, W. N., Douglas, E., Apostolidou, S., Moore, G. E., Maher, E. R. & Reik, W., 15 Jan 2004, In : Human Molecular Genetics. 13, 2, p. 247-255 9 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops

Murrell, A., Heeson, S. & Reik, W., Aug 2004, In : Nature Genetics. 36, 8, p. 889-93 5 p.

Research output: Contribution to journalArticle

400 Citations (Scopus)