Adele Murrell

2025

Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing

Halliwell, D. O., Honig, F., Bagby, S., Roy, S. & Murrell, A., 15 Feb 2025, In: Communications Biology. 8, 1, 1 p., 243.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters

Richer, S., Tian, Y., Schoenfelder, S., Hurst, L., Murrell, A. & Pisignano, G., 3 Mar 2023, In: Genome Biology. 24, 1, 40 .

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (SciVal)

2020

5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation

Uribe-Lewis, S., Carroll, T., Menon, S., Nicholson, A., Manasterski, P. J., Winton, D. J., Buczacki, S. J. A. & Murrell, A., 17 Jan 2020, In: Scientific Reports. 10, 1, 546.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (SciVal)

Apc ^Min/+ tumours and normal mouse small intestines show linear metabolite concentration and DNA cytosine hydroxymethylation gradients from pylorus to colon

Madhu, B., Uribe-Lewis, S., Bachman, M., Murrell, A. & Griffiths, J. R., 12 Aug 2020, In: Scientific Reports. 10, 1, 10 p., 13616.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (SciVal)

2019

Being in a loop: how long non-coding RNAs organise genome architecture

Pisignano, G., Pavlaki, I. & Murrell, A., 9 Apr 2019, In: Essays in Biochemistry. 63, 1, p. 177-186 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

17 Citations (SciVal)

307 Downloads (Pure)

2016

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Ross-Adams, H., Ball, S., Lawrenson, K., Halim, S., Russell, R., Wells, C., Strand, S. H., Ørntoft, T. F., Larson, M., Armasu, S., Massie, C. E., Asim, M., Mortensen, M. M., Borre, M., Woodfine, K., Warren, A. Y., Lamb, A. D., Kay, J., Whitaker, H. & Ramos-Montoya, A. & 8 others, Murrell, A., Sørensen, K. D., Fridley, B. L., Goode, E. L., Gayther, S. A., Masters, J., Neal, D. E. & Mills, I. G., 9 Oct 2016, In: Oncotarget. 7, 46, p. 74734-74746 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Citations (SciVal)

Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions: 2

Stojic, L., Niemczyk, M., Orjalo, A., Ito, Y., Ruijter, A. E. M., Uribe-Lewis, S., Joseph, N., Weston, S., Menon, S., Odom, D. T., Rinn, J., Gergely, F. & Murrell, A., 2 Feb 2016, In: Nature Communications. 7, 10406.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Citations (SciVal)

104 Downloads (Pure)

What lies beneath the epigenetic signatures associated with breast cancer and how do we find out?

Murrell, A., 22 Jul 2016.

Research output: Contribution to conference › Abstract › peer-review

2015

5-Formylcytosine can be a stable DNA modification in mammals

Bachman, M., Uribe-Lewis, S., Yang, X., Burgess, H. E., Iurlaro, M., Reik, W., Murrell, A. & Balasubramanian, S., 13 Aug 2015, In: Nature Chemical Biology. 11, 8, p. 555-557 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

206 Citations (SciVal)

150 Downloads (Pure)

5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer

Uribe-lewis, S., Stark, R., Carroll, T., Dunning, M. J., Bachman, M., Ito, Y., Stojic, L., Halim, S., Vowler, S. L., Lynch, A. G., Delatte, B., De Bony, E. J., Colin, L., Defrance, M., Krueger, F., Silva, A.-L., Ten Hoopen, R., Ibrahim, A. E., Fuks, F. & Murrell, A., 1 Apr 2015, In: Genome Biology. 16, 1, p. 1-15 15 p., 69.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Citations (SciVal)

Analysis of DNA methylation patterns in single blastocysts by Pyrosequencing(®).

Huntriss, J., Woodfine, K., Huddleston, J. E., Murrell, A. & Picton, H. M., 2015, Pyrosequencing: Methods and Protocols - Part III. Lehmann, U. & Tost, J. (eds.). New York, U. S. A.: Humana Press, p. 259-270 (Methods in Molecular Biology; vol. 1315).

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

5 Citations (SciVal)

Epigenetics and disease

Murrell, A., Nov 2015, Epigenetics for Drug Discovery. Carey, N. (ed.). Abingdon, U. K.: Royal Society of Chemistry, p. 47-67 21 p. (RSC Drug Discovery Series; vol. January 2016, no. 48).

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress

Delatte, B., Jeschke, J., Defrance, M., Bachman, M., Creppe, C., Calonne, E., Bizet, M., Deplus, R., Marroquí, L., Libin, M., Ravichandran, M., Mascart, F., Eizirik, D. L., Murrell, A., Jurkowski, T. P. & Fuks, F., 4 Aug 2015, In: Scientific Reports. 5, 12714.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Citations (SciVal)

2014

5-Hydroxymethylcytosine is a predominantly stable DNA modification

Bachman, M., Uribe-Lewis, S., Yang, X., Williams, M., Murrell, A. & Balasubramanian, S., 1 Dec 2014, In: Nature Chemistry. 6, 12, p. 1049-1055 7 p.

Research output: Contribution to journal › Article › peer-review

424 Citations (SciVal)

Cross-talk between imprinted loci in Prader-Willi syndrome

Murrell, A., Jun 2014, In: Nature Genetics. 46, 6, p. 528-530 3 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (SciVal)

Erratum: Cross-talk between imprinted loci in Prader-Willi syndrome (Nature Genetics (2014) 46 (528-530))

Murrell, A., 26 Jun 2014, In: Nature Genetics. 46, 7, p. 759 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

2013

A novel mechanism for CTCF in the epigenetic regulation of Bax in breast cancer cells

Méndez-Catalá, C. F., Gretton, S., Vostrov, A., Pugacheva, E., Farrar, D., Ito, Y., Docquier, F., Kita, G.-X., Murrell, A., Lobanenkov, V. & Klenova, E., Aug 2013, In: Neoplasia : An International Journal for Oncology Research. 15, 8, p. 898-912 15 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (SciVal)

Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins

Wu, L., Murat, P., Matak-Vinkovic, D., Murrell, A. & Balasubramanian, S., 31 Dec 2013, In: Biochemistry. 52, 52

Research output: Contribution to journal › Article › peer-review

152 Citations (SciVal)

Epigenetic mechanisms in development and disease

Murrell, A., Hurd, P. J. & Wood, I. C., 23 May 2013, In: Biochemical Society Transactions. 41, 3, p. 697-699 3 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA

Niemczyk, M., Ito, Y., Huddleston, J., Git, A., Abu-Amero, S., Caldas, C., Moore, G., Stojic, L. & Murrell, A., 8 Aug 2013, In: American Journal of Human Genetics. 93, 2, p. 224-235

Research output: Contribution to journal › Article › peer-review

36 Citations (SciVal)

Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus

Ito, Y., Nativio, R. & Murrell, A., 1 May 2013, In: Nucleic Acids Research. 41, 10, p. 5290-302 13 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (SciVal)

2012

Diverse epigenetic strategies interact to control epidermal differentiation

Mulder, K. W., Wang, X., Escriu, C., Ito, Y., Schwarz, R. F., Gillis, J., Sirokmány, G., Donati, G., Uribe-Lewis, S., Pavlidis, P., Murrell, A., Markowetz, F. & Watt, F. M., 1 Jul 2012, In: Nature cell biology. 14, 7, p. 753-763 11 p.

Research output: Contribution to journal › Article › peer-review

122 Citations (SciVal)

Quantitative chromosome conformation capture

Nativio, R., Ito, Y. & Murrell, A., 2012, In: Methods in Molecular Biology. 925, p. 173-185 13 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (SciVal)

Status of genomic imprinting in epigenetically distinct pluripotent stem cells

Sun, B., Ito, M., Mendjan, S., Ito, Y., Brons, I. G. M., Murrell, A., Vallier, L., Ferguson-Smith, A. C. & Pedersen, R. A., Feb 2012, In: Stem Cells . 30, 2, p. 161-168 8 p.

Research output: Contribution to journal › Article › peer-review

35 Citations (SciVal)

2011

Disruption of genomic neighbourhood at the imprinted IGF₂-H₁₉ locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome

Nativio, R., Sparago, A., Ito, Y., Weksberg, R., Riccio, A. & Murrell, A., 1 Apr 2011, In: Human Molecular Genetics. 20, 7, p. 1363-1374 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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80 Citations (SciVal)

202 Downloads (Pure)

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets

Sandovici, I., Smith, N. H., Nitert, M. D., Ackers-Johnson, M., Uribe-Lewis, S., Ito, Y., Jones, R. H., Marquez, V. E., Cairns, W., Tadayyon, M., O'Neill, L. P., Murrell, A., Ling, C., Constância, M. & Ozanne, S. E., 29 Mar 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 13, p. 5449-54 6 p.

Research output: Contribution to journal › Article › peer-review

296 Citations (SciVal)

Molecular mechanisms of genomic imprinting and clinical implications for cancer

Uribe-Lewis, S., Woodfine, K., Stojic, L. & Murrell, A., 2011, In: Expert Reviews in Molecular Medicine. 13, e2.

Research output: Contribution to journal › Article › peer-review

68 Citations (SciVal)

Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue

Woodfine, K., Huddleston, J. E. & Murrell, A., 31 Jan 2011, In: Epigenetics & Chromatin. 4, 1, 1.

Research output: Contribution to journal › Article › peer-review

Open Access

File

87 Citations (SciVal)

196 Downloads (Pure)

Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing

Huntriss, J., Woodfine, K., Huddleston, J. E., Murrell, A., Rutherford, A. J., Elder, K., Khan, A. A., Hemmings, K. & Picton, H., 30 Jun 2011, In: Fertility and Sterility. 95, 8, p. 2564-2567.e8

Research output: Contribution to journal › Article › peer-review

12 Citations (SciVal)

Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression

Ibrahim, A. E. K., Arends, M. J., Silva, A.-L., Wyllie, A. H., Greger, L., Ito, Y., Vowler, S. L., Huang, T.H.-M., Tavaré, S., Murrell, A. & Brenton, J. D., Apr 2011, In: Gut. 60, 4, p. 499-508 10 p.

Research output: Contribution to journal › Article › peer-review

126 Citations (SciVal)

Setting up and maintaining differential insulators and boundaries for genomic imprinting

Murrell, A., Oct 2011, In: Biochemistry and Cell Biology . 89, 5, p. 469-478 10 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (SciVal)

2010

Beyond genomic imprinting

Murrell, A., Jul 2010, In: Briefings in Functional Genomics. 9, 4, p. 279-280

Research output: Contribution to journal › Article › peer-review

1 Citation (SciVal)

Evaluation of allelic expression of imprinted genes in adult human blood

Frost, J. M., Monk, D., Stojilkovic-Mikic, T., Woodfine, K., Chitty, L. S., Murrell, A., Stanier, P. & Moore, G. E., 2010, In: PLoS ONE. 5, 10, e13556.

Research output: Contribution to journal › Article › peer-review

Open Access

File

25 Citations (SciVal)

180 Downloads (Pure)

Genomic imprinting and cancer: Remembering the parental origin

Murrell, A. & Uribe-Lewis, S., 1 Oct 2010, In: Biochemist. 32, 5, p. 26-29 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation

Farrar, D., Rai, S., Chernukhin, I., Jagodic, M., Ito, Y., Yammine, S., Ohlsson, R., Murrell, A. & Klenova, E., Mar 2010, In: Molecular and Cellular Biology. 30, 5, p. 1199-1216 18 p.

Research output: Contribution to journal › Article › peer-review

71 Citations (SciVal)

2009

Cohesin is required for higher-order chromatin conformation at the imprinted IGF₂-H₁₉ locus

Nativio, R., Wendt, K. S., Ito, Y., Huddleston, J. E., Uribe-lewis, S., Woodfine, K., Krueger, C., Reik, W., Peters, J.-M. & Murrell, A., 26 Nov 2009, In: Plos Genetics. 5, 11, p. e1000739

Research output: Contribution to journal › Article › peer-review

274 Citations (SciVal)

DNA Methylation Arrays: Methods and Analysis

Thorne, N. P., Marioni, J. C., Rakyan, V. K., Ibrahim, A. E. K., Massie, C. E., Curtis, C., Brenton, J. D., Murrell, A. & Tavaré, S., 31 Dec 2009, Microarray Innovations: Technology and Experimentation. Hardiman, G. (ed.). CRC Press, p. 175-205 31 p.

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

3 Citations (SciVal)

Generation of an epigenetic signature by chronic hypoxia in prostate cells

Watson, J. A., Watson, C. J., McCrohan, A.-M., Woodfine, K., Tosetto, M., McDaid, J., Gallagher, E., Betts, D., Baugh, J., O'Sullivan, J., Murrell, A., Watson, R. W. G. & McCann, A., 1 Oct 2009, In: Human Molecular Genetics. 18, 19, p. 3594-3604 11 p.

Research output: Contribution to journal › Article › peer-review

91 Citations (SciVal)

The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene

Chua, Y. L., Ito, Y., Pole, J. C. M., Newman, S., Chin, S. F., Stein, R. C., Ellis, I. O., Caldas, C., O'Hare, M. J., Murrell, A. & Edwards, P. A. W., 5 Oct 2009, In: Oncogene. 28, 46, p. 4041-4052 12 p.

Research output: Contribution to journal › Article › peer-review

62 Citations (SciVal)

2008

Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer

Murrell, A., Ito, Y., Verde, G., Huddleston, J., Woodfine, K., Silengo, M. C., Spreafico, F., Perotti, D., De Crescenzo, A., Sparago, A., Cerrato, F. & Riccio, A., 2008, In: PLoS ONE. 3, 3, e1849.

Research output: Contribution to journal › Article › peer-review

93 Citations (SciVal)

Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis

Tomazou, E. M., Rakyan, V. K., Lefebvre, G., Andrews, R., Ellis, P., Jackson, D. K., Langford, C., Francis, M. D., Bäckdahl, L., Miretti, M., Coggill, P., Ottaviani, D., Sheer, D., Murrell, A. & Beck, S., 2008, In: BMC Medical Genomics. 1, 19.

Research output: Contribution to journal › Article › peer-review

Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer

Barber, M., Murrell, A., Ito, Y., Maia, A. T., Hyland, S., Oliveira, C., Save, V., Carneiro, F., Paterson, A. L., Grehan, N., Dwerryhouse, S., Lao-Sirieix, P., Caldas, C. & Fitzgerald, R. C., 14 Aug 2008, In: Journal of Pathology. 216, 3, p. 295-306 12 p.

Research output: Contribution to journal › Article › peer-review

111 Citations (SciVal)

Somatically acquired hypomethylation of IGF₂ in breast and colorectal cancer

Ito, Y., Koessler, T., Ibrahim, A. E. K., Rai, S., Vowler, S. L., Abu-Amero, S., Silva, A.-L., Maia, A.-T., Huddleston, J. E., Uribe-Lewis, S., Woodfine, K., Jagodic, M., Nativio, R., Dunning, A., Moore, G., Klenova, E., Bingham, S., Pharoah, P. D. P., Brenton, J. D. & Beck, S. & 2 others, Sandhu, M. S. & Murrell, A., 1 Sept 2008, In: Human Molecular Genetics. 17, 17, p. 2633-2643 11 p.

Research output: Contribution to journal › Article › peer-review

116 Citations (SciVal)

2006

Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation

Lovett, F. A., Gonzalez, I., Salih, D. A. M., Cobb, L. J., Tripathi, G., Cosgrove, R. A., Murrell, A., Kilshaw, P. J. & Pell, J. M., 1 Dec 2006, In: Journal of Cell Science. 119, 23, p. 4828-4840 13 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (SciVal)

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2

Kurukuti, S., Tiwari, V. K., Tavoosidana, G., Pugacheva, E., Murrell, A., Zhao, Z., Lobanenkov, V., Reik, W. & Ohlsson, R., 11 Jul 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 28, p. 10684-10689 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

419 Citations (SciVal)

Genomic imprinting and cancer: from primordial germ cells to somatic cells.

Murrell, A., 1 May 2006, In: TheScientificWorldJournal. 6, p. 1888-1910 23 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

36 Citations (SciVal)

Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human

Monk, D., Sanches, R., Arnaud, P., Apostolidou, S., Hills, F. A., Abu-Amero, S., Murrell, A., Friess, H., Reik, W., Stanier, P., Constância, M. & Moore, G. E., 10 Mar 2006, In: Human Molecular Genetics. 15, 8, p. 1259-1269 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

128 Citations (SciVal)

2005

From genome to epigenome

Murrell, A., Rakyan, V. K. & Beck, S., 15 Apr 2005, In: Human Molecular Genetics. 14, SPEC. ISS. 1, p. R3-R10

Research output: Contribution to journal › Review article › peer-review

144 Citations (SciVal)

2004

An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype

Murrell, A., Heeson, S., Cooper, W. N., Douglas, E., Apostolidou, S., Moore, G. E., Maher, E. R. & Reik, W., 15 Jan 2004, In: Human Molecular Genetics. 13, 2, p. 247-255 9 p.

Research output: Contribution to journal › Article › peer-review

137 Citations (SciVal)

Chromosome loops, insulators, and histone methylation: New insights into regulation of imprinting in clusters

Reik, W., Murrell, A., Lewis, A., Mitsuya, K., Umlauf, D., Dean, W., Higgins, M. & Feil, R., 31 Dec 2004, In: Cold Spring Harbor Symposia on Quantitative Biology. 69, p. 29-37 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (SciVal)

Adele Murrell

Research output

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