Department of Pharmacy & Pharmacology

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2020

A new medium-throughput screening design approach for the development of hydroxymethylnitrofurazone (NFOH) nanostructured lipid carrier for treating leishmaniasis

de Souza, A., Yukuyama, M. N., Barbosa, E. J., Monteiro, L. M., Faloppa, A. C. B., Calixto, L. A., de Barros Araújo, G. L., Fotaki, N., Löbenberg, R. & Bou-Chacra, N. A., 1 May 2020, In : Colloids and Surfaces B: Biointerfaces. 193, 111097.

Research output: Contribution to journalArticle

Back pain, ankylosing spondylitis and social media usage; a descriptive analysis of current activity

Reilly, E. & Sengupta, R., 19 May 2020, In : Rheumatology International. RHEI-D-20-00213R1.

Research output: Contribution to journalArticle

Open Access

Biopharmaceutical understanding of excipient variability on drug apparent solubility based on drug physicochemical properties. Case study: Hypromellose (HPMC)

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 2020, In : AAPS Journal. 22, 49.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Biopharmaceutical understanding of excipient variability on drug apparent solubility based on drug physicochemical properties. Case study: Superdisintegrants

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 31 Mar 2020, In : AAPS Journal. 22, 2, 46.

Research output: Contribution to journalArticle

Open Access

Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy

Yin, L., Masuyer, G., Zhang, S., Zhang, J., Miyashita, S-I., Burgin, D., Lovelock, L., Coker, S-F., Fu, T., Stenmark, P. & Dong, M., 17 Mar 2020, In : PLoS Biology. 18, 3, E3000618.

Research output: Contribution to journalArticle

Open Access

Cholix Protein Domain I Functions as a Carrier Element for Efficient Apical to Basal Epithelial Transcytosis

Taverner, A., Mackay, J., Laurent, F., Hunter, T., Liu, K., Mangat, K., Song, L., Seto, E., Postlethwaite, S., Alam, A., Chandalia, A., Seung, M., Saberi, M., Feng, W. & Mrsny, R., 13 Jan 2020, In : Tissue Barriers. 1710429.

Research output: Contribution to journalArticle

Open Access
1 Downloads (Pure)

Crystal Structure of Exotoxin A from Aeromonas Pathogenic Species

Masuyer, G., 15 Jun 2020, In : Toxins . 12, 6, 397.

Research output: Contribution to journalArticle

Open Access

Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones

Maksimainen, M., Nurmesjärvi, A., Terho, R., Threadgill, M., Lehtiö, L. & Heiskanen, J., 2020, In : ACS OMEGA.

Research output: Contribution to journalArticle

Development of an Aerosol Dose Collection Apparatus for In Vitro Dissolution Measurements of Orally Inhaled Drug Products

Price, R., Shur, J., Ganley, W., Farias, G., Fotaki, N., Conti, D. S., Delvadia, R., Absar, M., Saluja, B. & Lee, S., 1 Mar 2020, In : AAPS Journal. 22, 2, 47.

Research output: Contribution to journalArticle

Open Access

Differing commissioning arrangements may contribute to geographic variation in clinical management of digital ulcers in systemic sclerosis

Reilly, E., Alshakh, R., Beynon, C., Cates, M., Das, D., Majeed, S., Memon, A., O'Beirn, P., Ritchie, J. & Pauling, J. D., 31 May 2020, In : Clinical Medicine. 20, 3, p. 343-345 CM-2020-0031.

Research output: Contribution to journalArticle

Drug initiation and escalation strategies of vasodilator therapies for Raynaud's phenomenon: Can we treat to target?

Hughes, M., Khanna, D. & Pauling, J. D., 1 Mar 2020, In : Rheumatology (United Kingdom). 59, 3, p. 464-466 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Drug Target Review

Lloyd, M., 26 May 2020, Drug Target Review, 7, 2, p. 11-14.

Research output: Contribution to specialist publicationArticle

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Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys

Maguire, D. R., Gerak, L. R., Sanchez, J. J., Javors, M. A., Disney, A., Husbands, S. M. & France, C. P., 6 May 2020, In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1 Citation (Scopus)
Open Access
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13 Downloads (Pure)

High prevalence of albuminuria amongst people who inject drugs: A cross-sectional study

McGowan, C. R., Wright, T., Nitsch, D., Lewer, D., Braithwaite, R., Scott, J., Hope, V., Ciccarone, D., Dunn, J., Gilmore, J., Story, A. & Harris, M., 27 Apr 2020, In : Scientific Reports. 10, 1, p. 7059 7059.

Research output: Contribution to journalArticle

Open Access

High-Throughput Screening For The Discovery Of Enzyme Inhibitors

Lloyd, M., 20 May 2020, In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Identifying drug combinations associated with acute kidney injury using association rules method

Nishtala, P. & Chyou, T., 1 Apr 2020, In : Pharmacoepidemiology and Drug Safety. 29, 4, p. 467-473 7 p.

Research output: Contribution to journalArticle

Impact of Anticholinergic Burden on Cognitive Performance: A Cohort Study of Community-Dwelling Older Adults

Nishtala, P., Allore, H., Han, L., Jamieson, H., Hilmer, S. N. & Chyou, T-Y., 10 May 2020, In : Journal of the American Medical Directors Association.

Research output: Contribution to journalArticle

Impact of Magnesium Stearate Presence and Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 21 May 2020, In : AAPS Journal. 22, 4, 75.

Research output: Contribution to journalArticle

Open Access

Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

Jungwirth, U., van Weverwijk, A., Jenkins, L., Alexander, J., Vicente, D., Gao, Q., Haider, S., Iravani, M. & Isacke, C. M., 17 May 2020, (Submitted) In : bioRxiv.

Research output: Contribution to journalArticle

Implementation of a standardised annual anticoagulation specialist review in primary care

Hutchinson-Jones, N., Didcott, S., Jones, M. & Crowe, J., 9 Jun 2020, In : Primary Health Care Research and Development. 21, p. e17 e17.

Research output: Contribution to journalArticle

Open Access
2 Downloads (Pure)

Investigation of drug partition kinetics to fat in simulated fed state gastric conditions based on drug properties

Baxevanis, F., Zarmpi, P., Kuiper, J. & Fotaki, N., 15 Apr 2020, In : European Journal of Pharmaceutical Sciences. 146, 105263.

Research output: Contribution to journalArticle

Modifiable risk factors and the development of psoriatic arthritis in people with psoriasis

PROMPT Study Group, 31 Mar 2020, In : British Journal of Dermatology. 182, 3, p. 714-720 7 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Morphine-induced respiratory depression is independent of β-arrestin2 signalling

Kliewer, A., Gillis, A., Hill, R., Schmidel, F., Bailey, C., Kelly, E., Henderson, G., Christie, M. J. & Schulz, S., 12 Feb 2020, In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Navigating environmental constraints to injection preparation: the use of saliva and other alternatives to sterile water among unstably housed PWID in London

Harris, M., Scott, J., Hope, V., Wright, T., McGowan, C. R. & Ciccerone, D., 10 Apr 2020, In : Harm Reduction Journal. 17, 1, 1 p., 24.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants: an Exploratory Study Highlighting the Importance of Infant Food

Statelova, M., Goumas, K., Fotaki, N., Holm, R., Symillides, M., Reppas, C. & Vertzoni, M., 1 Jan 2020, In : AAPS Journal. 22, 1, 6.

Research output: Contribution to journalArticle

1 Citation (Scopus)

OREX-1019: a novel treatment for opioid use disorder and relapse prevention

Maguire, D., Gerak, L., Cami-Kobeci, G., Husbands, S., France, C., Belli, B. & Flynn, P., 1 Feb 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 205-215

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Outcomes of the 2019 GRAPPA workshop on continuous composite indices for the assessment of psoriatic arthritis and membership-recommended next steps

Tillett, W., McHugh, N., Orbai, A-M., Ogdie, A., Leung, Y. Y., Coates, L. C., Mease, P. J., Gladman, D. D., Brooke, M. & Packham, J., 20 May 2020, (Acceptance date) In : The Journal of Rheumatology and Supplements. 96, p. 11-18 8 p.

Research output: Contribution to journalArticle

PARP10 influences the proliferation of colorectal carcinoma cells, a preliminary study

Wu, C., Xiao, M., Wang, Y., Threadgill, M., Li, M., Tang, Y., Lin, X., Yang, L., Li, Q. & Li, X., 31 Mar 2020, In : Molecular Biology. 54, 2, p. 220-228 9 p.

Research output: Contribution to journalArticle

Open Access
File

Personalised adherence support for maintenance treatment of inflammatory bowel disease: a tailored online intervention to change adherence-related beliefs and barriers

Chapman, S., Sibeli, A., St Clair-Jones, A., Chater, A., Forbes, A. & Horne, R., 7 May 2020, In : Journal of Crohns and Colitis. jjz034.

Research output: Contribution to journalArticle

Prediction of Drug Loading in the Gelatin Matrix Using Computational Methods

Hathout, R. M., Metwally, A. A., Woodman, T. J. & Hardy, J. G., 28 Jan 2020, In : ACS OMEGA. 5, 3, p. 1549-1556

Research output: Contribution to journalArticle

Open Access

Pseudopterosin and O-methyltylophorinidine suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma

Xie, B., Haensel, J., Mundorf, V., Betz, J., Reimche, I., Erkan, M., Buedeyri, I., Gessell, A., Kerr, R., Ariantari, N. P., Yu, H., Proksch, P., Teusch, N. & Mrsny, R., 13 Jun 2020, (Acceptance date) In : Bioengineering.

Research output: Contribution to journalArticle

Selenium status in diet affects acetaminophen-induced hepatotoxicity via interruption of redox environment

Li, J., Cheng, P., Li, S., Zhao, P., Han, B., Ren, X., Zhong, J. L., Lloyd, M., Pourzand, C., Holmgren, A. & Lu, J., 10 Jun 2020, In : Antioxidants & Redox Signaling.

Research output: Contribution to journalArticle

Open Access
Open Access
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Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells

Alexander, B. E., Sun, S., Palframan, M. J., Kociok-Köhn, G., Dibwe, D. F., Watanabe, S., Caggiano, L., Awale, S. & Lewis, S. E., 7 Jan 2020, In : ChemMedChem. 15, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

Open Access
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24 Downloads (Pure)

Silk fibroin/gelatin microcarriers as scaffolds for bone tissue engineering

Luetchford, K., Chaudhuri, J. & De Bank, P., 1 Jan 2020, In : Materials Science & Engineering C. 106, p. 1-9 9 p., 110116.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
15 Downloads (Pure)

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Ahmed, S., Nur-e-Alam, M., Parveen, I., Coles, S. J., Hafizur, R. M., Hameed, A., Orton, J. B., Threadgill, M. D., Yousaf, M., Alqahtani, A. M. & Al-Rehaily, A. J., 1 Feb 2020, In : Phytochemistry. 170, 112213.

Research output: Contribution to journalArticle