Department of Pharmacy & Pharmacology

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2020

Accelerating the development of novel technologies and tools for the subcutaneous delivery of biotherapeutics

Collins, D. S., Sanchez-Felix, M., Badkar, A. V. & Mrsny, R., 24 Feb 2020, In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Open Access

Biopharmaceutical understanding of excipient variability on drug apparent solubility based on drug physicochemical properties. Case study: Hypromellose (HPMC)

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 2020, In : AAPS Journal. 22, 49.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Biopharmaceutical understanding of excipient variability on drug apparent solubility based on drug physicochemical properties. Case study: Superdisintegrants

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 31 Mar 2020, In : AAPS Journal. 22, 2, 46.

Research output: Contribution to journalArticle

Open Access

Cholix Protein Domain I Functions as a Carrier Element for Efficient Apical to Basal Epithelial Transcytosis

Taverner, A., Mackay, J., Laurent, F., Hunter, T., Liu, K., Mangat, K., Song, L., Seto, E., Postlethwaite, S., Alam, A., Chandalia, A., Seung, M., Saberi, M., Feng, W. & Mrsny, R., 13 Jan 2020, In : Tissue Barriers. 1710429.

Research output: Contribution to journalArticle

Open Access

Development of an Aerosol Dose Collection Apparatus for In Vitro Dissolution Measurements of Orally Inhaled Drug Products

Price, R., Shur, J., Ganley, W., Farias, G., Fotaki, N., Conti, D. S., Delvadia, R., Absar, M., Saluja, B. & Lee, S., 1 Mar 2020, In : AAPS Journal. 22, 2, 47.

Research output: Contribution to journalArticle

Open Access
2 Downloads (Pure)

Investigation of drug partition kinetics to fat in simulated fed state gastric conditions based on drug properties

Baxevanis, F., Zarmpi, P., Kuiper, J. & Fotaki, N., 12 Feb 2020, In : European Journal of Pharmaceutical Sciences. 105263.

Research output: Contribution to journalArticle

Morphine-induced respiratory depression is independent of β-arrestin2 signalling

Kliewer, A., Gillis, A., Hill, R., Schmidel, F., Bailey, C., Kelly, E., Henderson, G., Christie, M. J. & Schulz, S., 12 Feb 2020, In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Open Access

On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants: an Exploratory Study Highlighting the Importance of Infant Food

Statelova, M., Goumas, K., Fotaki, N., Holm, R., Symillides, M., Reppas, C. & Vertzoni, M., 1 Jan 2020, In : AAPS Journal. 22, 1, 6.

Research output: Contribution to journalArticle

OREX-1019: a novel treatment for opioid use disorder and relapse prevention

Maguire, D., Gerak, L., Cami-Kobeci, G., Husbands, S., France, C., Belli, B. & Flynn, P., 1 Feb 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 205-215

Research output: Contribution to journalArticle

Prediction of Drug Loading in the Gelatin Matrix Using Computational Methods

Hathout, R. M., Metwally, A. A., Woodman, T. J. & Hardy, J. G., 28 Jan 2020, In : ACS OMEGA. 5, 3, p. 1549-1556

Research output: Contribution to journalArticle

Open Access
Open Access

Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells

Alexander, B. E., Sun, S., Palframan, M. J., Kociok-Köhn, G., Dibwe, D. F., Watanabe, S., Caggiano, L., Awale, S. & Lewis, S. E., 7 Jan 2020, In : ChemMedChem. 15, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

Open Access
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Silk fibroin/gelatin microcarriers as scaffolds for bone tissue engineering

Luetchford, K., Chaudhuri, J. & De Bank, P., 1 Jan 2020, In : Materials Science & Engineering C. 106, p. 1-9 9 p., 110116.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
10 Downloads (Pure)

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Ahmed, S., Nur-e-Alam, M., Parveen, I., Coles, S. J., Hafizur, R. M., Hameed, A., Orton, J. B., Threadgill, M. D., Yousaf, M., Alqahtani, A. M. & Al-Rehaily, A. J., 1 Feb 2020, In : Phytochemistry. 170, 112213.

Research output: Contribution to journalArticle

Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 15 Mar 2020, In : International Journal of Pharmaceutics. 577, 119080.

Research output: Contribution to journalArticle

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR)

Potter, B., Watt, J. M. & Baszczynski, O., 2020, In : RSC Advances. 10, 3, p. 1776-1785

Research output: Contribution to journalArticle

Open Access

Telephone delivered incentives for encouraging adherence to supervised methadone consumption (TIES): Study protocol for a feasibility study for an RCT of clinical and cost effectiveness

Metrebian, N., Weaver, T., Pilling, S., Goldsmith, K., Carr, E., Shearer, J., Woolston-Thomas, K., Tas, B., Getty, C. A., Cooper, C., van der Waal, R., Kelleher, M., Finch, E., Bijral, P., Taylor, D., Scott, J. & Strang, J., 1 Mar 2020, In : Contemporary Clinical Trials Communications. 17, 100506.

Research output: Contribution to journalArticle

Open Access
2 Downloads (Pure)

Tumour Necrosis Factor Inhibitor monotherapy versus combination therapy for the treatment of psoriatic arthritis: combined analysis of European biologics databases

Thomas, M., Shaddick, G., Charlton, R., Cavill, C., Holland, R., Iannone, F., Lapadula, G., Lopriore, S., Zavada, J., Uher, M., Pavelka, K., Szczukova, L., Sidiropolous, P., Flouri, I., Drosos, A., Möller, B., Nissen, M., Müller, R., Scherer, A., McHugh, N. & 1 others, Nightingale, A., 5 Mar 2020, (Accepted/In press) In : The Journal of Rheumatology.

Research output: Contribution to journalArticle

2019

(Un)spoken realities of living with axial spondyloarthritis: a qualitative study focused on couple experiences

Raybone, K., Family, H., Sengupta, R. & Jordan, A., 3 Jul 2019, In : BMJ Open. 9, 7, p. 1-8 8 p., e025261.

Research output: Contribution to journalArticle

Open Access
2 Downloads (Pure)

19F and 1H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids

Naqi, H., Woodman, T., Husbands, S. & Blagbrough, I., 28 Jun 2019, In : Analytical Methods. 11, 24, p. 3090-3100 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Naqi, H., Husbands, S. & Blagbrough, I., 7 Oct 2019, In : Analytical Methods. 11, 37, p. 4795-4807 13 p.

Research output: Contribution to journalArticle

Open Access

A beginner's guide to nuclear magnetic resonance: From atomic spies to complex 3D structures at the heart of structural biology

Woodman, T. J., 30 Jun 2019, In : Biochemist. 41, 3, p. 52-55 4 p.

Research output: Contribution to journalArticle

Open Access

A Complex Interplay of Anionic Phospholipid Binding Regulates 3′-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation

de Las Heras-Martinez, G., Calleja, V., Bailly, R., Dessolin, J., Larijani, B. & Requejo-Isidro, J., 10 Oct 2019, In : Scientific Reports. 9, 1, p. 1-18 18 p., 14527.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Amyloid peptide β 1-42 induces integrin α IIb β 3 activation, platelet adhesion, and thrombus formation in a NADPH Oxidase-Dependent Manner

Abubaker, A. A., Vara, D., Visconte, C., Eggleston, I., Torti, M., Canobbio, I. & Pula, G., 14 Mar 2019, In : Oxidative Medicine and Cellular Longevity. 2019, p. 1-12 12 p., 1050476.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
1 Citation (Scopus)

A neurotoxin that specifically targets Anopheles mosquitoes

Contreras, E., Masuyer, G., Qureshi, N., Chawla, S., Dhillon, H. S., Lee, H. L., Chen, J., Stenmark, P. & Gill, S. S., 28 Jun 2019, In : Nature Communications. 10, 1, p. 1-10 10 p., 2869.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

A novel G protein-biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic pain

Conibear, A. E., Asghar, J., Hill, R., Henderson, G., Borbely, E., Tekus, V., Helyes, Z., Palandri, J., Bailey, C. P., Starke, I., von Mentzer, B., Kendall, D. & Kelly, E., 8 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics.

Research output: Contribution to journalArticle

Open Access

A qualitative exploration of the experiences of community dwelling older adults with sensory impairment/s receiving polypharmacy on their pharmaceutical care journey

Smith, A., Macaden, L., Kroll, T., Alhusein, N., Taylor, A., Killick, K., Stoddart, K. & Watson, M., 1 Nov 2019, In : Age and Ageing. 48, 6, p. 895-902 8 p.

Research output: Contribution to journalArticle

Open Access
3 Downloads (Pure)

A simple, robust, universal assay for real-time enzyme monitoring by signalling changes in nucleoside phosphate anion concentration using a europium(III)-based anion receptor

Hewitt, S., Ali, R., Mailhot, R., Antonen, C., Dodson, C. & Butler, S., 28 May 2019, In : Chemical Science. 10, 20, p. 5373-5381 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

A simple 1H NMR based assay of total capsaicinoid levels in Capsicum using signal suppression in non-deuterated solvent

Woodman, T. & Negoescu, E., 15 Mar 2019, In : Journal of the Science of Food and Agriculture. 99, 4, p. 1765-1771 7 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
34 Downloads (Pure)

Association of Diverticulitis with Prolonged Spondyloarthritis: An Analysis of the ASAS-COMOSPA International Cohort

BRITSpA and the ASAS-COMOSPA Investigators, 26 Feb 2019, In : Journal of Clinical Medicine. 8, 3, 281.

Research output: Contribution to journalArticle

Open Access

A Threshold of Meaning for Work Disability Improvement in Psoriatic Arthritis Measured by the Work Productivity and Activity Impairment Questionnaire

Tillett, W., Lin, C-Y., Zbrozek, A., Sprabery, A. T. & Birt, J., 1 Sep 2019, In : Rheumatology and therapy. 6, 3, p. 379-391 13 p.

Research output: Contribution to journalArticle

Open Access

Biorelevant release testing of biodegradable microspheres intended for intra-articular administration

Magri, G., Selmin, F., Cilurzo, F. & Fotaki, N., 1 Jun 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 139, p. 115-122 8 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
1 Downloads (Pure)

BU10038 as a safe opioid analgesic with fewer side effects after systemic and intrathecal administration in primates

Kiguchi, N., Ding, H., Cami-Kobeci, G., Sukhtankar, D. D., Czoty, P. W., DeLoid, H. B., Hsu, F. -C., Toll, L., Husbands, S. & Ko, M. C., 1 Jun 2019, In : British Journal of Anaesthesia. 122, 6, p. e146-e156

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
2 Downloads (Pure)

Co-delivery of buparvaquone and polymyxin B in a nanostructured lipid carrier for leishmaniasis treatment

Monteiro, L. M., Löbenberg, R., Fotaki, N., Barros de Araujo, G. L., Cotrim, P. C. & Bou-Chacra, N. A., 1 Sep 2019, In : Journal of Global Antimicrobial Resistance. 18, p. 279-283 5 p.

Research output: Contribution to journalArticle

Open Access

Comparison of Three Immunoassays for the Detection of Myositis Specific Antibodies

Mahler, M., Betteridge, Z., Bentow, C., Richards, M., Seaman, A., Chinoy, H. & McHugh, N., 30 Apr 2019, In : Frontiers in Immunology. 10, p. 1-5 5 p., 848.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Consumer internet purchasing of medicines using a population sample: A mixed methodology approach

Bowman, C., Family, H., Agius-Muscat, H., Cordina, M. & Sutton, J., 13 Sep 2019, In : Research in Social and Administrative Pharmacy. p. 1-9 9 p.

Research output: Contribution to journalArticle

Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin

Košenina, S., Masuyer, G., Zhang, S., Dong, M. & Stenmark, P., 1 Jun 2019, In : FEBS Letters. 593, 12, p. 1403-1410 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Open Access
File
3 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
9 Downloads (Pure)

Development of a peptide-based fluorescent probe for biological heme monitoring

Newton, L. D., Pascu, S. I., Tyrrell, R. M. & Eggleston, I. M., 21 Jan 2019, In : Organic and Biomolecular Chemistry. 17, 3, p. 467-471 5 p.

Research output: Contribution to journalArticle

Open Access