Department of Pharmacy & Pharmacology

Research Output

2020

Accelerating the development of novel technologies and tools for the subcutaneous delivery of biotherapeutics

Collins, D. S., Sanchez-Felix, M., Badkar, A. V. & Mrsny, R., 24 Feb 2020, In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Open Access

Biopharmaceutical understanding of excipient variability on drug apparent solubility based on drug physicochemical properties. Case study: Hypromellose (HPMC)

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 2020, In : AAPS Journal. 22, 49.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Biopharmaceutical understanding of excipient variability on drug apparent solubility based on drug physicochemical properties. Case study: Superdisintegrants

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 11 Feb 2020, In : AAPS Journal. 22, 2, 46.

Research output: Contribution to journalArticle

Open Access

Cholix Protein Domain I Functions as a Carrier Element for Efficient Apical to Basal Epithelial Transcytosis

Taverner, A., Mackay, J., Laurent, F., Hunter, T., Liu, K., Mangat, K., Song, L., Seto, E., Postlethwaite, S., Alam, A., Chandalia, A., Seung, M., Saberi, M., Feng, W. & Mrsny, R., 13 Jan 2020, In : Tissue Barriers. 1710429.

Research output: Contribution to journalArticle

Open Access

Development of an Aerosol Dose Collection Apparatus for In Vitro Dissolution Measurements of Orally Inhaled Drug Products

Price, R., Shur, J., Ganley, W., Farias, G., Fotaki, N., Conti, D. S., Delvadia, R., Absar, M., Saluja, B. & Lee, S., 1 Mar 2020, In : AAPS Journal. 22, 2, 47.

Research output: Contribution to journalArticle

Open Access
2 Downloads (Pure)

Investigation of drug partition kinetics to fat in simulated fed state gastric conditions based on drug properties

Baxevanis, F., Zarmpi, P., Kuiper, J. & Fotaki, N., 12 Feb 2020, In : European Journal of Pharmaceutical Sciences. 105263.

Research output: Contribution to journalArticle

Morphine-induced respiratory depression is independent of β-arrestin2 signalling

Kliewer, A., Gillis, A., Hill, R., Schmidel, F., Bailey, C., Kelly, E., Henderson, G., Christie, M. J. & Schulz, S., 12 Feb 2020, In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Open Access

On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants: an Exploratory Study Highlighting the Importance of Infant Food

Statelova, M., Goumas, K., Fotaki, N., Holm, R., Symillides, M., Reppas, C. & Vertzoni, M., 1 Jan 2020, In : AAPS Journal. 22, 1, 6.

Research output: Contribution to journalArticle

OREX-1019: a novel treatment for opioid use disorder and relapse prevention

Maguire, D., Gerak, L., Cami-Kobeci, G., Husbands, S., France, C., Belli, B. & Flynn, P., 1 Feb 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 205-215

Research output: Contribution to journalArticle

Prediction of Drug Loading in the Gelatin Matrix Using Computational Methods

Hathout, R. M., Metwally, A. A., Woodman, T. J. & Hardy, J. G., 28 Jan 2020, In : ACS OMEGA. 5, 3, p. 1549-1556

Research output: Contribution to journalArticle

Open Access
Open Access

Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells

Alexander, B. E., Sun, S., Palframan, M. J., Kociok-Köhn, G., Dibwe, D. F., Watanabe, S., Caggiano, L., Awale, S. & Lewis, S. E., 7 Jan 2020, In : ChemMedChem. 15, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

Open Access
File
14 Downloads (Pure)

Silk fibroin/gelatin microcarriers as scaffolds for bone tissue engineering

Luetchford, K., Chaudhuri, J. & De Bank, P., 1 Jan 2020, In : Materials Science & Engineering C. 106, p. 1-9 9 p., 110116.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
10 Downloads (Pure)

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Ahmed, S., Nur-e-Alam, M., Parveen, I., Coles, S. J., Hafizur, R. M., Hameed, A., Orton, J. B., Threadgill, M. D., Yousaf, M., Alqahtani, A. M. & Al-Rehaily, A. J., 1 Feb 2020, In : Phytochemistry. 170, 112213.

Research output: Contribution to journalArticle

Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J. & Fotaki, N., 15 Mar 2020, In : International Journal of Pharmaceutics. 577, 119080.

Research output: Contribution to journalArticle

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR)

Potter, B., Watt, J. M. & Baszczynski, O., 2020, In : RSC Advances. 10, 3, p. 1776-1785

Research output: Contribution to journalArticle

Open Access

Telephone delivered incentives for encouraging adherence to supervised methadone consumption (TIES): Study protocol for a feasibility study for an RCT of clinical and cost effectiveness

Metrebian, N., Weaver, T., Pilling, S., Goldsmith, K., Carr, E., Shearer, J., Woolston-Thomas, K., Tas, B., Getty, C. A., Cooper, C., van der Waal, R., Kelleher, M., Finch, E., Bijral, P., Taylor, D., Scott, J. & Strang, J., 1 Mar 2020, In : Contemporary Clinical Trials Communications. 17, 100506.

Research output: Contribution to journalArticle

Open Access
2 Downloads (Pure)

Tumour Necrosis Factor Inhibitor monotherapy versus combination therapy for the treatment of psoriatic arthritis: combined analysis of European biologics databases

Thomas, M., Shaddick, G., Charlton, R., Cavill, C., Holland, R., Iannone, F., Lapadula, G., Lopriore, S., Zavada, J., Uher, M., Pavelka, K., Szczukova, L., Sidiropolous, P., Flouri, I., Drosos, A., Möller, B., Nissen, M., Müller, R., Scherer, A., McHugh, N. & 1 others, Nightingale, A., 5 Mar 2020, (Accepted/In press) In : The Journal of Rheumatology.

Research output: Contribution to journalArticle

2019

(Un)spoken realities of living with axial spondyloarthritis: a qualitative study focused on couple experiences

Raybone, K., Family, H., Sengupta, R. & Jordan, A., 3 Jul 2019, In : BMJ Open. 9, 7, p. 1-8 8 p., e025261.

Research output: Contribution to journalArticle

Open Access
2 Downloads (Pure)

19F and 1H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids

Naqi, H., Woodman, T., Husbands, S. & Blagbrough, I., 28 Jun 2019, In : Analytical Methods. 11, 24, p. 3090-3100 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Naqi, H., Husbands, S. & Blagbrough, I., 7 Oct 2019, In : Analytical Methods. 11, 37, p. 4795-4807 13 p.

Research output: Contribution to journalArticle

Open Access

A beginner's guide to nuclear magnetic resonance: From atomic spies to complex 3D structures at the heart of structural biology

Woodman, T. J., 30 Jun 2019, In : Biochemist. 41, 3, p. 52-55 4 p.

Research output: Contribution to journalArticle

Open Access

ACHIEVEMENT OF PASDAS LOW DISEASE ACTIVITY AND VERY LOW DISEASE ACTIVITY IN PATIENTS WITH PSORIATIC ARTHRITIS TREATED WITH CERTOLIZUMAB PEGOL OVER 4 YEARS AND THE OVERLAP WITH DAPSA AND MDA DISEASE ACTIVITY TARGETS

Coates, L. C., Merola, J. F., Fitzgerald, O., Kavanaugh, A., Gottlieb, A. B., Tillett, W., Bauer, L., Hoepken, B., Nurminen, T., Mease, P. J., Helliwell, P. & Heijde, D. V. D., 27 Jun 2019, In : Annals of the Rheumatic Diseases. 78, Suppl 2, 2 p., AB0742.

Research output: Contribution to journalMeeting abstract

A Complex Interplay of Anionic Phospholipid Binding Regulates 3′-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation

de Las Heras-Martinez, G., Calleja, V., Bailly, R., Dessolin, J., Larijani, B. & Requejo-Isidro, J., 10 Oct 2019, In : Scientific Reports. 9, 1, p. 1-18 18 p., 14527.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Amyloid peptide β 1-42 induces integrin α IIb β 3 activation, platelet adhesion, and thrombus formation in a NADPH Oxidase-Dependent Manner

Abubaker, A. A., Vara, D., Visconte, C., Eggleston, I., Torti, M., Canobbio, I. & Pula, G., 14 Mar 2019, In : Oxidative Medicine and Cellular Longevity. 2019, p. 1-12 12 p., 1050476.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
1 Citation (Scopus)

A neurotoxin that specifically targets Anopheles mosquitoes

Contreras, E., Masuyer, G., Qureshi, N., Chawla, S., Dhillon, H. S., Lee, H. L., Chen, J., Stenmark, P. & Gill, S. S., 28 Jun 2019, In : Nature Communications. 10, 1, p. 1-10 10 p., 2869.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

A novel G protein-biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic pain

Conibear, A. E., Asghar, J., Hill, R., Henderson, G., Borbely, E., Tekus, V., Helyes, Z., Palandri, J., Bailey, C. P., Starke, I., von Mentzer, B., Kendall, D. & Kelly, E., 8 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics.

Research output: Contribution to journalArticle

Open Access

Application of Pharmacoepidemiology and Pharmacovigilance Studies

Nishtala, P. & Wati Narayan, S., Nov 2019, Application of Pharmacoepidemiology and Pharmacovigilance Studies. Elsevier, p. 445-450 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence: a PEARRL review

Loisios-Konstantinidis, I., Paraiso, R. L. M., Fotaki, N., McAllister, M., Cristofoletti, R. & Dressman, J., 1 Apr 2019, In : Journal of Pharmacy and Pharmacology. 71, 4, p. 699-723 25 p.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
1 Downloads (Pure)

A qualitative exploration of the experiences of community dwelling older adults with sensory impairment/s receiving polypharmacy on their pharmaceutical care journey

Smith, A., Macaden, L., Kroll, T., Alhusein, N., Taylor, A., Killick, K., Stoddart, K. & Watson, M., 1 Nov 2019, In : Age and Ageing. 48, 6, p. 895-902 8 p.

Research output: Contribution to journalArticle

Open Access
2 Downloads (Pure)

A simple, robust, universal assay for real-time enzyme monitoring by signalling changes in nucleoside phosphate anion concentration using a europium(III)-based anion receptor

Hewitt, S., Ali, R., Mailhot, R., Antonen, C., Dodson, C. & Butler, S., 28 May 2019, In : Chemical Science. 10, 20, p. 5373-5381 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

A simple 1H NMR based assay of total capsaicinoid levels in Capsicum using signal suppression in non-deuterated solvent

Woodman, T. & Negoescu, E., 15 Mar 2019, In : Journal of the Science of Food and Agriculture. 99, 4, p. 1765-1771 7 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
32 Downloads (Pure)

Association of Diverticulitis with Prolonged Spondyloarthritis: An Analysis of the ASAS-COMOSPA International Cohort

BRITSpA and the ASAS-COMOSPA Investigators, 26 Feb 2019, In : Journal of Clinical Medicine. 8, 3, 281.

Research output: Contribution to journalArticle

Open Access
13 Downloads (Pure)

Association rule analysis to evaluate frequent drug combinations associated with acute kidney injury in older adults

Nishtala, P., 1 Aug 2019, p. 425-425. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
1 Citation (Scopus)
19 Downloads (Pure)

A Threshold of Meaning for Work Disability Improvement in Psoriatic Arthritis Measured by the Work Productivity and Activity Impairment Questionnaire

Tillett, W., Lin, C-Y., Zbrozek, A., Sprabery, A. T. & Birt, J., 1 Sep 2019, In : Rheumatology and therapy. 6, 3, p. 379-391 13 p.

Research output: Contribution to journalArticle

Open Access

Autoantibodies in connective tissuedisease

Mulhearn, B., Tansley, S. L. & McHugh, N. J., 14 Dec 2019, In : Best Practice and Research Clinical Rheumatology . 101462.

Research output: Contribution to journalReview article