Department of Biology & Biochemistry

Research Output

2017

A polychromatic 'greenbeard' locus determines patterns of cooperation in a social amoeba

Gruenheit, N., Parkinson, K., Stewart, B., Howie, J. A., Wolf, J. B. & Thompson, C. R. L., 25 Jan 2017, In : Nature Communications. 8, 14171.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers

Pisignano, G., Napoli, S., Magistri, M., Mapelli, S. N., Pastori, C., Di Marco, S., Civenni, G., Albino, D., Enriquez, C., Allegrini, S., Mitra, A., D'Ambrosio, G., Mello-Grand, M., Chiorino, G., Garcia-Escudero, R., Varani, G., Carbone, G. M. & Catapano, C. V., 30 May 2017, In : Nature Communications. 8, 15622.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

A proposal for a genome similarity-based taxonomy for plant-pathogenic bacteria that is sufficiently precise to reflect phylogeny, host range, and outbreak affiliation applied to Pseudomonas syringae sensu lato as a proof of concept

Vinatzer, B. A., Weisberg, A. J., Monteil, C. L., Elmarakeby, H. A., Sheppard, S. K. & Heath, L. S., 1 Jan 2017, In : Phytopathology. 107, 1, p. 18-28 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

Mishra, A., Oules, B., Pisco, A. O., Ly, T., Liakath-Ali, K., Walko, G., Viswanathan, P., Tihy, M., Nijjher, J., Dunn, S-J., Lamond, A. I. & Watt, F. M., 2 Nov 2017, In : eLife. 6, p. 1-20 20 p., e27356.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

A spatial temporal analysis of the Fusarium graminearum transcriptome during symptomless and symptomatic wheat infection

Brown, N. A., Evans, J., Mead, A. & Hammond-Kosack, K. E., 1 Dec 2017, In : Molecular Plant Pathology. 18, 9, p. 1295-1312 18 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Aspects of host-pathogen interactions as applied in breeding for disease resistance against Ganoderma stem rots, Fusarium wilt, and spear/bud rots

Cooper, R., Aug 2017, Oil Palm Breeding, Genetics and Genomics.. Soh, A. C., Mayes, S. & Roberts, J. A. (eds.). CRC Press, p. 106-119 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Assessment of the influence of direct tobacco smoke on infection and active TB management

PII Smoking SEPAR Working Group, 24 Aug 2017, In : PLoS ONE. 12, 8, p. 1-17 17 p., e0182998.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Assisted reproductive technologies to prevent human mitochondrial disease transmission

Greenfield, A., Braude, P., Flinter, F., Lovell-Badge, R., Ogilvie, C. & Perry, A., 14 Dec 2017, In : Nature Biotechnology. 35, p. 1059-1068 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
3 Citations (Scopus)

A structural variant in the 5′-flanking region of the TWIST2 gene affects melanocyte development in belted cattle

Awasthi Mishra, N., Droegemueller, C., Jagannathan, V., Keller, I., Wuthrich, D., Bruggmann, R., Beck, J., Schuetz, E., Brenig, B., Demmel, S., Moser, S., Signer-Hasler, H., Pienkowska-Schelling, A., Schelling, C., Sande, M., Rongen, R., Rieder, S., Kelsh, R. N., Mercader, N. & Leeb, T., 28 Jun 2017, In : PLoS ONE. 12, 6, 16 p., e0180170.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

A subset of high Gleason grade prostate carcinomas contain a large burden of prostate cancer syndecan-1 positive stromal cells

Sharpe, B., Alghezi, D. A., Cattermole, C., Beresford, M., Bowen, R., Mitchard, J. & Chalmers, A. D., 15 Sep 2017, In : Prostate. 77, 13, p. 1312-1324 13 p., 23391.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
35 Downloads (Pure)

Autoantibodies in juvenile-onset myositis: Their diagnostic value and associated clinical phenotype in a large UK cohort

on behalf of the Juvenile Dermatomyositis Research Group, 1 Nov 2017, In : Journal of Autoimmunity. 84, p. 55-64 10 p.

Research output: Contribution to journalArticle

Open Access
31 Citations (Scopus)

Bacterial toxins: Offensive, defensive, or something else altogether?

Rudkin, J. K., McLoughlin, R. M., Preston, A. & Massey, R. C., 30 Sep 2017, In : PLoS Pathogens. 13, 9, e1006452.

Research output: Contribution to journalReview article

Open Access
12 Citations (Scopus)

Big-time insights from a tiny bird fossil

Field, D., 25 Jun 2017, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 114, 30, p. 7750-7752

Research output: Contribution to journalEditorial

File
2 Citations (Scopus)
37 Downloads (Pure)

Body length of bony fishes was not a selective factor during the biggest mass extinction of all time

Puttick, M. N., Kriwet, J., Wen, W., Hu, S., Thomas, G. H. & Benton, M. J., 1 Sep 2017, In : Palaeontology. 60, 5, p. 727-741 15 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Both maintenance and avoidance of RNA-binding protein interactions constrain coding region evolution

Savisaar, R. & Hurst, L., 1 May 2017, In : Molecular Biology and Evolution. 34, 5, p. 1110-1126

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
154 Downloads (Pure)

Ca2+-permeable AMPA receptor: A new perspective on amyloid-beta mediated pathophysiology of Alzheimer's disease

Whitehead, G., Regan, P., Whitcomb, D. J. & Cho, K., 1 Jan 2017, In : Neuropharmacology. 112, Pt A, p. 221-227 7 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Candida's Hidden Weakness: Characterising Novel Hsp90 Interactions to Discover New Drug Targets in Candidaemia

Crunden, J., Sep 2017, (Unpublished).

Research output: Contribution to conferencePoster

Cassava post-harvest physiological deterioration: From triggers to symptoms

Zainuddin, I. M., Fathoni, A., Sudarmonowati, E., Beeching, J. R., Gruissem, W. & Vanderschuren, H., 2017, (Accepted/In press) In : Postharvest Biology and Technology.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Cell surface dynamics and cellular distribution of endogenous FcRn

D'Hooghe, L., D Chalmers, A., Heywood, S. & Whitley, P., 17 Aug 2017, In : PLoS ONE. 12, 8, e0182695.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Centrifugal partition chromatography in a biorefinery context: Optimisation and scale-up of monosaccharide fractionation from hydrolysed sugar beet pulp

Ward, D. P., Hewitson, P., Cárdenas-Fernández, M., Hamley-Bennett, C., Díaz-Rodríguez, A., Douillet, N., Adams, J. P., Leak, D. J., Ignatova, S. & Lye, G. J., 12 May 2017, In : Journal of Chromatography A. 1497, p. 56-63 8 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Characterization of nasal methicillin-resistant Staphylococcus aureus isolated from international human and veterinary surgeons

Post, V., Harris, L. G., Morgenstern, M., Geoff Richards, R., Sheppard, S. K. & Fintan Moriarty, T., 1 Mar 2017, In : Journal of Medical Microbiology. 66, 3, p. 360-370 11 p., 000415.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization of the first naturally thermostable terpene synthases and development of strategies to improve thermostability in this family of enzymes

Styles, M. Q., Nesbitt, E. A., Marr, S., Hutchby, M. & Leak, D. J., Jun 2017, In : FEBS Journal. 284, 11, p. 1700-1711

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Climate-driven shifts in adult sex ratios via sex reversals: The type of sex determination matters

Bókony, V., Kövér, S., Nemesházi, E., Liker, A. & Székely, T., 19 Sep 2017, In : Proceedings of the Royal Society B: Biological Sciences. 372, 1729, 20160325.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Clonal differences in Staphylococcus aureus bacteraemia-associated mortality

Recker, M., Laabei, M., Toleman, M. S., Reuter, S., Saunderson, R. B., Blane, B., Estee Török, M., Ouadi, K., Stevens, E., Yokoyama, M., Steventon, J., Thompson, L., Milne, G., Bayliss, S., Bacon, L., Peacock, S. J. & Massey, R. C., 1 Oct 2017, In : Nature Microbiology. 2, 10, p. 1381-1388 8 p.

Research output: Contribution to journalArticle

Open Access
37 Citations (Scopus)

Comparative analyses of selection operating on non-translated intergenic regions of diverse bacterial species

Thorpe, H. A., Bayliss, S. C., Hurst, L. D. & Feil, E. J., 5 May 2017, In : Genetics. 206, 1, p. 363-376 195784.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Complete Ichthyornis skull reveals unforeseen mosaicism late in the dinosaur-bird transition

Field, D., Hanson, M. & Bhullar, B-A. S., 2017.

Research output: Contribution to conferenceAbstract

Computational prediction and design for creating iteratively larger heterospecific coiled coil sets

Crooks, R., Lathbridge, A., Panek, A. & Mason, J., 21 Mar 2017, In : Biochemistry. 56, 11, p. 1573-1584

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
126 Downloads (Pure)

Corrigendum: Genome reduction for niche association in Campylobacter Hepaticus, a cause of spotty liver disease in poultry [Front. Cell. Infect. Microbiol. 7, (2017), (354)] doi: 10.3389/fcimb.2017.00354

Petrovska, L., Tang, Y., van Rensburg, M. J. J., Cawthraw, S., Nunez, J., Sheppard, S. K., Ellis, R. J., Whatmore, A. M., Crawshaw, T. R. & Irvine, R. M., 14 Nov 2017, In : Frontiers in Cellular and Infection Microbiology. 7, NOV, 480.

Research output: Contribution to journalComment/debate

Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro

Bradshaw, W. J., Kirby, J. M., Roberts, A. K., Shone, C. C. & Acharya, K. R., 1 Sep 2017, In : FEBS Journal. 284, 17, p. 2886-2898 13 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase

Stevens, E., Laabei, M., Gardner, S., Somerville, G. A. & Massey, R. C., 1 Dec 2017, In : Scientific Reports. 7, 1, 13744.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Defining a core genome multilocus sequence typing scheme for the global epidemiology of Vibrio parahaemolyticus

Gonzalez-Escalona, N., Jolley, K. A., Reed, E. & Martinez-Urtaza, J., 1 Jun 2017, In : Journal of Clinical Microbiology. 55, 6, p. 1682-1697

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Dental data perform relatively poorly in reconstructing mammal phylogenies: Morphological partitions evaluated with molecular benchmarks

Sansom, R. S., Wills, M. A. & Williams, T., 30 Sep 2017, In : Systematic Biology. 66, 5, p. 813-822 10 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
131 Downloads (Pure)

Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Hurst, L. & Batada, N. N., 7 Nov 2017, In : Genome Biology. 18, 1, 12 p., 213.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Developmental and paleontological perspectives on the origin of the avian beak

Bhullar, B-A. S., Hanson, M., Botelho, J., Smith-Paredes, D., Faunes, M., Field, D., Fabbri, M., Burnham, D. & Wilson, L., 2017.

Research output: Contribution to conferenceAbstract

Development of an efficient technique for gene deletion and allelic exchange in Geobacillus spp.

Bacon, L. F., Hamley-Bennett, C., Danson, M. J. & Leak, D. J., 5 Apr 2017, In : Microbial Cell Factories. 16, 1, 8 p., 58.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Differences between hard and soft phylogenetic data

Sansom, R. S. & Wills, M. A., 20 Dec 2017, In : Proceedings of the Royal Society B: Biological Sciences. 284, 1869, 20172150.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Differences in carbon source utilization of Salmonella Oranienburg and Saintpaul isolated from river water

Medrano-Félix, A., Estrada-Acosta, M., Peraza-Garay, F., Castro-del Campo, N., Martínez-Urtaza, J. & Chaidez, C., 31 May 2017, In : International Journal of Environmental Health Research. 27, 4, p. 1-12 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Differential growth rate in the wings of ratite embryos support independent flight loss mechanisms

Faux, C. & Field, D., 2017.

Research output: Contribution to conferenceAbstract

Direct determination of the mutation rate in the bumblebee reveals evidence for weak recombination-associated mutation and an approximate rate constancy in insects

Liu, H., Jia, Y., Sun, X., Tian, D., Hurst, L. D. & Yang, S., 1 Jan 2017, In : Molecular Biology and Evolution. 34, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Disease epidemiology and genetic diversity of fusarium oxysporum f. sp. elaeidis, cause of fusarium wilt of oil palm (Elaeis guineensis Jacq.)

Hefni Rusli, M., Wheals, A. E., Sharma, S., Seman, I. A. & Cooper, R. M., 1 Dec 2017, In : Journal of Oil Palm Research . 29, 4, p. 548-561 14 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
61 Downloads (Pure)

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

International Mouse Phenotyping Consortium, 1 Aug 2017, In : Nature Genetics. 49, 8, p. 1231-1238 8 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Distinct developmental pathways underlie independent losses of flight in ratites

Faux, C. & Field, D., 5 Jul 2017, In : Biology Letters. 13, 20170234.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
56 Downloads (Pure)

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

Zadora, J., Singh, M., Herse, F., Przybyl, L., Haasse, N., Golic, M., Yung, H. W., Huppertz, B., Cartwright, J. E., Whitley, G., Johnsen, G. M., Levi, G., Isbruch, A., Schulz, H., Luft, F. C., Muller, D. N., Staff, A. C., Hurst, L., Dechend, R. & Izsvak, Z., 7 Nov 2017, In : Circulation. 136, 19, p. 1824-1839 16 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Do antibiotics and antibiotic resistance genes play a role in enhancing antimicrobial resistance in wastewater?

Castrignano, E., Feil, E., Lewis, S., Cartwright, N., Barden, R. & Kasprzyk-Hordern, B., 2017.

Research output: Contribution to conferencePoster

Dosage-sensitive genes in evolution and disease

Rice, A. M. & McLysaght, A., 1 Sep 2017, In : BMC Biology. 15, 1, p. 1-10 10 p., 78.

Research output: Contribution to journalReview article

Open Access
14 Citations (Scopus)

Dosage sensitivity is a major determinant of human copy number variant pathogenicity

Rice, A. M. & McLysaght, A., 8 Feb 2017, In : Nature Communications. 8, 14366.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun

Baxter, D., Perry, S., Hill, T., Kok, W., Zaccai, N., Brady, L., Fairlie, D. & Mason, J., 17 Aug 2017, In : ACS Chemical Biology. 12, 8, p. 2051-2061 11 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
157 Downloads (Pure)

Draft genome sequences of Salinivibrio proteolyticus, Salinivibrio sharmensis, Salinivibrio siamensis, Salinivibrio costicola subsp. alcaliphilus, Salinivibrio costicola subsp. vallismortis, and 29 new isolates belonging to the genus Salinivibrio

López-Hermoso, C., de la Haba, R. R., Cristina Sánchez-Porro, S-P., Bayliss, S. C., Feil, E. J. & Ventosa, A., 1 Jul 2017, In : Genome announcements. 5, 27, e00244-17.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Kidger, A. M., Rushworth, L. K., Stellzig, J., Davidson, J., Bryant, C. J., Bayley, C., Caddye, E., Rogers, T., Keyse, S. M. & Caunt, C. J., 17 Jan 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. E317-E326 10 p.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)