Avance III 500 NMR Spectrometer 500 MHz Nuclear Magnetic Resonance instrument (NMR) (9West)

Facility/equipment: Equipment

  • Location

    9 W 0.03 University of Bath Claverton Down Bath BA2 7AY

    UK United Kingdom

Research Output

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Article
2019

Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships

Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103264.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents

Jevglevskis, M., Nathubhai, A., Wadda, K., Lee, G. L., Al-Rawi, S., Jiao, T., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103263.

Research output: Contribution to journalArticle

Open Access
File
66 Downloads (Pure)
2018

Structure-activity relationships of rationally designed AMACR 1A inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Sep 2018, In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
29 Downloads (Pure)
2017

A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 7 May 2017, In : Chemical Communications. 53, 37, p. 5087-5090 4 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2016

A study on the AMACR catalysed elimination reaction and its application to inhibitor testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T. D., Woodman, T. J. & Lloyd, M. D., Jan 2016, In : Organic and Biomolecular Chemistry. 14, 2, p. 612-622

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
75 Downloads (Pure)
2014

A hydrazide-anchored dendron scaffold for chemoselective ligation strategies

O'Donovan, L. & De Bank, P., 7 Oct 2014, In : Organic and Biomolecular Chemistry. 12, 37, p. 7290-7296 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
126 Downloads (Pure)

A study on the chiral inversion of mandelic acid in humans

Jevglevskis, M., Bowskill, C. R., Chan, C. C. Y., Heng, JH-J., Threadgill, M. D., Woodman, T. J. & Lloyd, M. D., 14 Sep 2014, In : Organic and Biomolecular Chemistry. 12, 34, p. 6737-6744 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
240 Downloads (Pure)
6 Citations (Scopus)
215 Downloads (Pure)
2013

Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. & Lloyd, M. D., 1 Dec 2013, In : Biochemical Pharmacology. 86, 11, p. 1621-1625 5 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
143 Downloads (Pure)
2011

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. & Lloyd, M. D., 14 Jul 2011, In : Chemical Communications. 47, 26, p. 7332-7334 3 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
144 Downloads (Pure)
2010

Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S)

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. & Lloyd, M. D., 21 May 2010, In : Chemical Communications. 46, 19, p. 3348-3350 3 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
128 Downloads (Pure)
2009

Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. & Lloyd, M. D., 7 Feb 2009, In : Organic and Biomolecular Chemistry. 7, 3, p. 543-552 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)