Avance III 500 NMR Spectrometer 500 MHz Nuclear Magnetic Resonance instrument (NMR) (9West)

Facility/equipment: Equipment

  • Location

    9 W 0.03 University of Bath Claverton Down Bath BA2 7AY

    UK United Kingdom

Research Output

2019

Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships

Petrova, Y., Wadda, K., Nathubhai, A., Jevglevskis, M., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103264.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents

Jevglevskis, M., Nathubhai, A., Wadda, K., Lee, G. L., Al-Rawi, S., Jiao, T., Mitchell, P., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Nov 2019, In : Bioorganic Chemistry. 92, 103263.

Research output: Contribution to journalArticle

Open Access
File
66 Downloads (Pure)
2018

Structure-activity relationships of rationally designed AMACR 1A inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 1 Sep 2018, In : Bioorganic and Medicinal Chemistry. 79, p. 145-154 10 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
29 Downloads (Pure)
2017

A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 21 Apr 2017, (Unpublished).

Research output: Contribution to conferenceAbstract

File
46 Downloads (Pure)

A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 7 May 2017, In : Chemical Communications. 53, 37, p. 5087-5090 4 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

High-Throughput Screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Petrova, Y., Mattan, H., Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 21 Apr 2017.

Research output: Contribution to conferencePoster

File
26 Downloads (Pure)

Methods (amacr)

Lloyd, M., Jevglevskis, M., Lee, G. L., Woodman, T. & Threadgill, M., 22 Jun 2017, Patent No. US20170176436 A1, Priority date 3 Feb 2014

Research output: Patent

2016

A convenient colorimetric assay for alpha-methylacyl-CoA racemase (AMACR; P504S) and testing for inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 21 May 2016, (Unpublished).

Research output: Contribution to conferencePoster

File
20 Downloads (Pure)

A Convenient Colorimetric Assay For Alpha-Methylacyl-CoA Racemase (AMACR; P504S) And Testing Of Inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., Threadgill, M., James, T., Woodman, T. & Lloyd, M., Jun 2016.

Research output: Contribution to conferencePoster

Open Access
File
32 Downloads (Pure)

A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 27 Apr 2016, (Unpublished).

Research output: Contribution to conferencePoster

File
33 Downloads (Pure)

A study on the AMACR catalysed elimination reaction and its application to inhibitor testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T. D., Woodman, T. J. & Lloyd, M. D., Jan 2016, In : Organic and Biomolecular Chemistry. 14, 2, p. 612-622

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
75 Downloads (Pure)

A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. & Lloyd, M., 27 Apr 2016, (Unpublished).

Research output: Contribution to conferencePoster

File
38 Downloads (Pure)

Methods (AMACR)

Lloyd, M., Jevglevskis, M., Lee, G. L., Woodman, T. & Threadgill, M., 14 Dec 2016, Patent No. EP3102694 A1, Priority date 3 Feb 2014

Research output: Patent

2015

A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. & Lloyd, M., 11 Nov 2015, (Unpublished).

Research output: Contribution to conferencePoster

File
29 Downloads (Pure)

A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. & Lloyd, M., 11 Nov 2015, (Unpublished).

Research output: Contribution to conferencePoster

File
31 Downloads (Pure)

Methods (AMACR).

Lloyd, M., Woodman, T., Jevglevskis, M., Threadgill, M. & Lee, G. L., 6 Aug 2015, IPC No. C12Q1/533; G01N33/574;, Patent No. WO 2015 /114383 A1 EP3102694 (A1) US2017176436 (A1) , 2 Feb 2015, Priority date 3 Feb 2014, Priority No. 1401817.0

Research output: Patent

File
26 Downloads (Pure)

New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR)

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. & Lloyd, M., 2015, (Unpublished).

Research output: Contribution to conferencePoster

New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR)

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. & Lloyd, M., 2015, (Unpublished).

Research output: Contribution to conferencePoster

New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR)

Lee, G. L., Jevglevskis, M., Woodman, T. & Lloyd, M., 2015, (Unpublished).

Research output: Contribution to conferencePoster

2014

A hydrazide-anchored dendron scaffold for chemoselective ligation strategies

O'Donovan, L. & De Bank, P., 7 Oct 2014, In : Organic and Biomolecular Chemistry. 12, 37, p. 7290-7296 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
126 Downloads (Pure)

A study on the chiral inversion of mandelic acid in humans

Jevglevskis, M., Bowskill, C. R., Chan, C. C. Y., Heng, JH-J., Threadgill, M. D., Woodman, T. J. & Lloyd, M. D., 14 Sep 2014, In : Organic and Biomolecular Chemistry. 12, 34, p. 6737-6744 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
240 Downloads (Pure)
6 Citations (Scopus)
215 Downloads (Pure)
2013

Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. & Lloyd, M. D., 1 Dec 2013, In : Biochemical Pharmacology. 86, 11, p. 1621-1625 5 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
143 Downloads (Pure)
2012

Acyl-CoA ∝-proton exchange by ∝-methylacyl-CoA racemase

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. & Lloyd, M. D., 2012.

Research output: Contribution to conferenceOther

File
30 Downloads (Pure)

Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. & Lloyd, M. D., 2012.

Research output: Contribution to conferencePoster

File
27 Downloads (Pure)

Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human Acyl-CoA thioesterases 1 and 2

Qu, X., Leung, A., Allan, A. C., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. & Lloyd, M. D., 2012.

Research output: Contribution to conferenceOther

File
30 Downloads (Pure)
2011

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. & Lloyd, M. D., 14 Jul 2011, In : Chemical Communications. 47, 26, p. 7332-7334 3 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
144 Downloads (Pure)

Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. & Lloyd, M. D., 2011.

Research output: Contribution to conferenceOther

2010

Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S)

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. & Lloyd, M. D., 21 May 2010, In : Chemical Communications. 46, 19, p. 3348-3350 3 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
128 Downloads (Pure)
2009

Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. & Lloyd, M. D., 7 Feb 2009, In : Organic and Biomolecular Chemistry. 7, 3, p. 543-552 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2008

Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target

Darley, D. J., Butler, D. S., Threadgill, M. D. & Lloyd, M. D., Mar 2008.

Research output: Contribution to conferenceOther

Synthesis of 2-[2H]-2-[13C]-S-2-methyldecanoyl-CoA and 13C NMR study of its reaction with ∝-methylacyl-CoA racemase (AMACR

Darley, D. J., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Threadgill, M. D., Woodman, T. J. & Lloyd, M. D., Apr 2008.

Research output: Contribution to conferenceOther

Synthesis of 2-[2H]-2-[13C]-S-2-methyldecanoyl-CoA and 13C NMR study of its reaction with ∝-methylacyl-CoA racemase (AMACR

Darley, D. J., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Threadgill, M. D., Woodman, T. J. & Lloyd, M. D., Mar 2008.

Research output: Contribution to conferenceOther

2007

Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target

Darley, D. J., Butler, D. S., Threadgill, M. D. & Lloyd, M. D., Jul 2007.

Research output: Contribution to conferenceOther

Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target

Darley, D. J., Butler, D. S., Threadgill, M. D. & Lloyd, M. D., Nov 2007.

Research output: Contribution to conferenceOther

Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target

Darley, D. J., Butler, D. S., Threadgill, M. D. & Lloyd, M. D., Oct 2007.

Research output: Contribution to conferenceOther