Raw data composed of adipose tissue ex vivo secretion, adipose tissue macrophage abundances, adipose tissue T cell counts and proportions, T cell activation marker expression and leptin and insulin receptor expression in adipose tissue, peripheral blood T cell counts and proportions, T cell activation marker expression and leptin and insulin receptor expression in peripheral blood, peripheral blood monocyte proportions and expression of leptin and insulin receptors, adipose tissue metabolic gene expression, serum metabolic and inflammatory protein concentrations, basic participant anthropometrics, dietary energy intake and daily expenditure, DEXA-derived body composition, OGTT results, and energy intake prescriptions during a 3 day 50 % calorie restriction protocol in 12 overweight and obese males.