RSC Conformational design in drug discovery

Related content

• Datasets

• Single molecule experimental data for dwell time histogram in Gilburt et al, Angewandte Chemie 2017

  Dataset

• Single molecule experimental data for intensity histograms in Gilburt et al, Angewandte 2017

  Dataset

• Single molecule experimental data for unphosphorylated Aurora-A measurements in Gilburt et al, Chemical Science 2019

  Dataset

• Data for publication Girvan et al (2025) "Tetramethylrhodamine self-quenching is a probe of conformational change on the scale of 15 – 25 Å"

  Dataset

• Research output

• Tetramethylrhodamine self-quenching is a probe of conformational change on the scale of 15 - 25 Å

  Research output: Contribution to journal › Article › peer-review

• Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy

  Research output: Contribution to journal › Article › peer-review

• Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation

  Research output: Contribution to journal › Article › peer-review

• Projects

• Single molecule imaging to monitor conformational changes in clinically arising resistance mutations of protein kinases

  Project: Research council

• The effect of clinical mutations and kinase ligands on conformation and dynamics of protein kinase drug targets

  Project: Project at a former HEI

• Conformational selection in Aurora-A kinase: competition between activator- and inhibitor- promoted forms

  Project: Project at a former HEI

• Single molecule imaging to monitor conformational changes in clinically arising resistance mutations of protein kinases

  Project: UK charity

• Value in People Award

  Project: Project at a former HEI